DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and ACSF2

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001275897.1	Gene:	ACSF2 / 80221	HGNCID:	26101	Length:	640	Species:	Homo sapiens

Alignment Length:	575	Identity:	132/575 - (22%)
Similarity:	249/575 - (43%)	Gaps:	62/575 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GNIVYGGPVTERQAQDSRSLGQYILDKYKSFGDRTVLVDAVNGVEYSASFMHKSIVRLAYILQKL 72
            |.:.|....|::.. :|:::||.:....:...:|..||.....|..:.:.:.:.:.:.|..|..:
Human    81 GGLSYVQGCTKKHL-NSKTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSI 144

  Fly    73 GVKQNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVTYSDREVDHAI-NLSKPKIIFASKITID 136
            |:.:.|.:|:...||..:.|...|....|..:..:|..|...|:::.: .:....::|..:....
Human   145 GLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQ 209

  Fly   137 R---------------------------VAKVASKNKFVKGIIAL-----SGTSKKFKNIYDLKE 169
            :                           :..|.|.:..:.|.:.|     :|::::     .|.:
Human   210 QYYNVLKQICPEVENAQPGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQ-----HLDQ 269

  Fly   170 LMEDEKFKTQPDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLTQMNLLAT---LDSQIQPTVIPM 231
            |..:::|.:..|..:           |..:|||||.|||..|:..|::..   |..:::......
Human   270 LQYNQQFLSCHDPIN-----------IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTP 323

  Fly   232 EEVTLLTVIPWFHAFGCLTLITTACV--GARLVYL-PKFEEKLFLSAIEKYRVMMAFMVPPLMVF 293
            |::.::...|.:|..|.:. .|..|:  ||.|:.. |.|..|..|.||.:.|....:..|.:.|.
Human   324 EQLRMILPNPLYHCLGSVA-GTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVD 387

  Fly   294 LAKHPIVDKYDLSSLMVLLCGAAPLSRETEDQIKERIGVPFIRQGYGLSES---TLSVLVQNDEF 355
            :...|....||:|::...:...:|...|....|..:|.:..:...||.:|:   |.:...::...
Human   388 ILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVE 452

  Fly   356 CKPGSVGVLKVGIYAKVIDPDTGKLLGANERGELCFKGDGIMKGYIGDTKSTQTAI-KDGWLHTG 419
            .|..|||.:.....|::::.:.|.|...|..||||.:|..:|.||.|:.:.|:.|: :|.|..||
Human   453 QKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTG 517

  Fly   420 DIGYYDDDFEFFIVDRIKELIKYKGYQVPPAEIEALLLTNDKIKDAAVIGKPDEEAGELPLAFVV 484
            |:...::.....||.|.|::|...|..:.|||:|....|:.|:::..|:|..|:..||...|.:.
Human   518 DVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIR 582

  Fly   485 KQANVQLTENEVIQFVNDNASPAKRLRGGVIFVDEIPKNPSGKILRRILREMLKK 539
            .:...:.|..|:..|.....|..| :...::||...|...||||.:..|||.:::
Human   583 LKDGEETTVEEIKAFCKGKISHFK-IPKYIVFVTNYPLTISGKIQKFKLREQMER 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	128/553 (23%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	121/528 (23%)
ACSF2	NP_001275897.1	PRK08315	82..640	CDD:236236	131/574 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710