Protein Alignment CG6178 and AACS

DIOPT Version :10

• Sequence 1: NP_651221.1
• Gene: CG6178 / 42867
• FlyBaseID: FBgn0039156
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_076417.2
• Gene: AACS / 65985
• HGNCID: 21298
• Length: 672
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 109/582 - (18%)
• Similarity: 221/582 - (37%)
• Gaps: 134/582 - (23%)

  Fly    40 DRTVLVDAVNG----VEYSASFMHKSIVRLAYILQKLGVKQND-VVGL--SSENSVNFALAMFAG 97
            ||..|..|..|    |:.:...:.:.:...|..::|:|||:.| |||.  :||::|.   ||.|.
Human   112 DRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAVE---AMLAA 173

  Fly    98 LAVGATVAPLNVTYSDREVDHAINLSKPKIIFASKITI---------DRVAKVASKNKFVKGIIA 153
            .::||..:..:..:....|....:..:||:||:.:..:         :::.:|......:|.::.
Human   174 ASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVV 238

  Fly   154 LSGTSKKFKNIYDLKEL-----MED------------EKFKTQPDFTSPAANKDEDVSLIVCSSG 201
            :...|.: :|| ||.::     ::|            .:|:..| |:.|.        .|:.|||
Human   239 IPYVSSR-ENI-DLSKIPNSVFLDDFLATGTSEQAPQLEFEQLP-FSHPL--------FIMFSSG 292

  Fly   202 TTGLPK-GVQLTQMNLLATLDSQIQPTVIPMEEVTL-LTVIPWFHAFGCLTLITTACV-----GA 259
            |||.|| .|......|:..|...:....:...::.| .|.:.|......::|:.|...     |:
Human   293 TTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLATGAAMVLYDGS 357

  Fly   260 RLVYLPKFEEKL--------------FLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDLSSLMV 310
            .||..|.....|              :||.:|:               .|..| |:.:.|..|..
Human   358 PLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEE---------------KAMKP-VETHSLQMLHT 406

  Fly   311 LLCGAAPLSRETEDQIKERIGVPFIRQGYGLSESTLSVLVQNDEFCKP---GSVGVLKVGIYAKV 372
            :|...:||..::.:.:...|....:..........:|..:.:: |..|   |.:....:|:..:.
Human   407 ILSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHN-FSLPVYKGEIQARNLGMAVEA 470

  Fly   373 IDPDTGKLLGANERGEL-CFK--------------GDGIMKGYIGDTKSTQTAIKDGWLH----- 417
            .:.:...:.|  |.||| |.|              |:...|.|.......       |.|
Human   471 WNEEGKAVWG--ESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGI-------WAHGDYCR 526

  Fly   418 ----TGDIGYYDDDFEFFIVDRIKELIKYKGYQVPPAEIEALLLTNDKIKDAAVIGKPDEEAGEL 478
                ||.|         .::.|....:...|.:...:||..::.:.::::|:..:.:.::...|.
Human   527 INPKTGGI---------VMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREER 582

  Fly   479 PLAFVVKQANVQLTENEVIQFVND---NASPAKRLRGGVIFVDEIPKNPSGKILRRILREML 537
            .:.| :|.|:....:.::::.:.|   ....|:.:...::....||...:||.:...:::::
Human   583 VILF-LKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQII 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	Adenylate forming domain, Class I superfamily	9..536	CDD:473059	109/579 (19%)
AACS	NP_076417.2	AACS	29..663	CDD:341265	109/582 (19%)