DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and ACSM3

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_024306135.1	Gene:	ACSM3 / 6296	HGNCID:	10522	Length:	633	Species:	Homo sapiens

Alignment Length:	535	Identity:	123/535 - (22%)
Similarity:	218/535 - (40%)	Gaps:	82/535 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NGVEYSASFMHKSIV--RLAYIL-QKLGVKQNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVT 110
            ||.|...||.....:  :.|.|| :...:::.|.|.|.......:.||..|.|..|..:.|....
Human    89 NGEEMRWSFEELGSLSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQ 153

  Fly   111 YSDREVDHAINLSKPKIIFASKITIDRVAKVASKNKFVKGIIALSGTSKKFKNIYDLKELMEDEK 175
            .:.:::.:.:..||...|..:.:....|..||||.:.:...:.:|..|:  :...:|||||  :.
Human   154 LTQKDILYRLQSSKANCIITNDVLAPAVDAVASKCENLHSKLIVSENSR--EGWGNLKELM--KV 214

  Fly   176 FKTQPDFTSPAAN----------------------------------KDEDVSLIVCSSGTTGLP 206
            |...|.:::.|.:                                  |..::..|..:|||:|.|
Human   215 FLCHPGWSTVARSWLTATSTSLVQAILSLLSSWDYRHASDSHTCVKTKHNEIMAIFFTSGTSGYP 279

  Fly   207 KGVQLT--QMNLLATLDSQIQPTVIPMEEV-----TLLTVIPWFHAFGCLTLITTACVGARLVYL 264
            |....|  ...|..:::.:....:.|.:.:     |......|...|.  ..|..|||...  :|
Human   280 KMTAHTHSSFGLGLSVNGRFWLDLTPSDVMWNTSDTGWAKSAWSSVFS--PWIQGACVFTH--HL 340

  Fly   265 PKFEEKLFLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDLSSLMVLLCGAAPLSRETEDQIKER 329
            |:||....|..:.||.:.:....|.:...|.::.|. .|...||...:....|::.:..::.:.:
Human   341 PRFEPTSILQTLSKYPITVFCSAPTVYRMLVQNDIT-SYKFKSLKHCVSAGEPITPDVTEKWRNK 404

  Fly   330 IGVPFIRQGYGLSESTLSVLVQNDEFC--------KPGSVGVLKVGIYAKVIDPDTGKLLGANER 386
            .|:. |.:|||.:|:.|        .|        ||||:|........|::|.: |.:|...:.
Human   405 TGLD-IYEGYGQTETVL--------ICGNFKGMKIKPGSMGKPSPAFDVKIVDVN-GNVLPPGQE 459

  Fly   387 GELCF-----KGDGIMKGYIGDTKSTQTAIKDGWLHTGDIGYYDDDFEFFIVDRIKELIKYKGYQ 446
            |::..     :..|:...|:.:...|.:.::..:..|||.||.|.|..|:.|.|..::|...||:
Human   460 GDIGIQVLPNRPFGLFTHYVDNPSKTASTLRGNFYITGDRGYMDKDGYFWFVARADDVILSSGYR 524

  Fly   447 VPPAEIEALLLTNDKIKDAAVIGKPDEEAGELPLAFVV-----KQANVQLTENEVIQFVNDNASP 506
            :.|.|:|..|..:..:.::||:..||...||:..||||     |..:.:....|:.:.|....:|
Human   525 IGPFEVENALNEHPSVAESAVVSSPDPIRGEVVKAFVVLNPDYKSHDQEQLIKEIQEHVKKTTAP 589

  Fly   507 AKRLRG-GVIFVDEI 520
            .|..|. |::.:..|
Human   590 YKYPRKVGILIITNI 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	123/535 (23%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	123/535 (23%)
ACSM3	XP_024306135.1	AFD_class_I	54..596	CDD:327384	121/525 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3623
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870