DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and dip2cb

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_005171457.1	Gene:	dip2cb / 569986	ZFINID:	ZDB-GENE-070912-589	Length:	1595	Species:	Danio rerio

Alignment Length:	681	Identity:	135/681 - (19%)
Similarity:	234/681 - (34%)	Gaps:	217/681 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKLLPGNIVYGGPVTERQAQDS-RSLG------QYI-LDKYKSFGDRT----VLVDAVN-----G 50
            :.::.||:|.|    :|.||.| |.|.      |:: |.:...:..:|    :|...:|     |
Zfish   968 ASVMVGNLVAG----KRMAQASGRDLSHMEDNEQFLFLSEMLQWRAQTTPEHILYTLINSRGAVG 1028

  Fly    51 VEYSASFMHKSIVRLAYILQKLG-VKQNDVVGLSSENSVNFALAMFAGLAVGA---TVA---PLN 108
            ...:...:||...::|.:|.:.| ::..|.|.|.....::...|.:..|..|.   ||.   |.|
Zfish  1029 SSLTCLQLHKRAEKIATLLYERGQLRDGDHVALVYPPGLDLIAAFYGCLYAGCIPITVRPPHPQN 1093

  Fly   109 VTYSDREVDHAINLSKPKIIFA----SKITIDRVAKVASKNKFVKGIIALSGTSKK-----FKNI 164
            ::.:...|...:.:|:...:..    ||:...|.|.||...|....|:......|:     ||
Zfish  1094 ISTTLPTVKMILEVSRSVCVMTSQMISKLLKSRDASVAVDFKLWPPILETDDLPKRRCPLMFK-- 1156

  Fly   165 YDLKELMEDEKFKTQPDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLTQMNLLATLDS-QIQPTV 228
                        ...||          .::.:..|..|||:..||:::.....|...| ::|..:
Zfish  1157 ------------PCDPD----------SLAYLDFSVSTTGMLAGVKMSHNATSALCRSVKLQCEL 1199

  Fly   229 IPMEEVTL-------LTVIPWFHAFGCLTLITTACVGARLVYLPKFE----EKLFLSAIEKYRVM 282
            .|..||.:       |..:.|     ||   .:...|.:.|.:...:    ..|:|.|:.:::|.
Zfish  1200 YPSREVAVCLDPYCGLGFVLW-----CL---CSVYAGQQSVLISPMDLEVNPALWLQAVSQFKVR 1256

  Fly   283 MAFMVPPLMVFLAKHPIVDKYDLSSL----------------MVLLCGAAPLSRETEDQIK---- 327
            ..|....:|....:       .||||                .|::....|....|:...|
Zfish  1257 DTFCSYSVMELCTR-------SLSSLTDTLKARGMDLTRVRSCVVVAEERPRVALTQSFCKLFKD 1314

  Fly   328 ------------------------ERIGVPFIRQG-YGLSESTLSV---LVQND-----EFCKPG 359
                                    .|:| ....|| .|...:|:.|   .:::|     |...|.
Zfish  1315 VGLHPRAVSTAFGCRVNLAICLQPHRLG-KLAEQGTSGPDPTTVYVDMRALRHDRVRLVERGSPH 1378

  Fly   360 SV-----GVLKVGIYAKVIDPDTGKLLGANERGELCFKGDGIMKGY------------------- 400
            |:     |.:..|:...:.:|:|...:|.:..||:.........||
Zfish  1379 SLPLMESGKILPGVRIIIANPETKGPIGDSHLGEIWVHSPQNASGYFTVFGEENVRSDHFGARLS 1443

  Fly   401 IGDTKSTQTAIKDGWLHTGDIGYY------DDDFE----FFIVDRIKELIKYKGYQVPPAEIE-A 454
            .|||::.       |..||.:|:.      |...|    .::|..:.|:::.:|.:..|.:|| :
Zfish  1444 FGDTQTV-------WARTGYLGFLRRTDLTDASGERHDALYVVGALDEVMELRGMKYHPIDIETS 1501

  Fly   455 LLLTNDKIKDAAVI-------------GKPDEEAGELPLAFVVKQANVQLTENEVIQFVNDNASP 506
            ::..:..|.:.||.             |...|....:|:.     .||.|.|:.:|.
Zfish  1502 IIRAHRNITECAVFTWTNLLVVVVELEGSEQEALDLVPMV-----TNVVLEEHYLIV-------- 1553

  Fly   507 AKRLRGGVIFVDE--IPKNPSGKILRRILRE 535
                 |.|:.||.  ||.|..|:..|..||:
Zfish  1554 -----GVVVVVDTGVIPINSRGEKQRMHLRD 1579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	126/657 (19%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	119/621 (19%)
dip2cb	XP_005171457.1	DMAP_binding	6..114	CDD:283995
		CaiC	349..940	CDD:223395
		AFD_class_I	375..937	CDD:302604
		AMP-binding	1005..1489	CDD:278902	97/530 (18%)
		AFD_class_I	1022..1584	CDD:302604	121/623 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900