DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and dip2bb

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_009300851.1	Gene:	dip2bb / 568954	ZFINID:	ZDB-GENE-100729-4	Length:	1615	Species:	Danio rerio

Alignment Length:	659	Identity:	124/659 - (18%)
Similarity:	236/659 - (35%)	Gaps:	172/659 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKLLPGNIVYGGPVTERQAQDSRSLG-------------------QYILD----KYKSFGDRT-- 42
            :.::.||:|.|..:.:...:|   ||                   |::.:    :.::..|.|
Zfish   987 ASIMVGNLVAGKRIAQAAGRD---LGLIEDQDLVRKLCMWPTMMHQFLTEALQWRAQTDPDHTLY 1048

  Fly    43 VLVDAVNGVEYSASF---MHKSIVRL-AYILQKLGVKQNDVVGLSSENSVNFALAMFAGLAVG-- 101
            ||::| .||....:.   :||...:: |.::::.|:...:.|.|.....::...|.:..|..|
Zfish  1049 VLLNA-KGVAVCTATCVQLHKRAEKIAAALMERSGINIGENVVLLYPPGIDLIAAFYGCLYAGCI 1112

  Fly   102 -ATVA---PLNVTYSDREVDHAINLSKPKIIFASKITIDRVAKVASKNKFVKGIIALSGTSKKFK 162
             .||.   |.|::.:...|...|::||...|..:::    :.|:....:     .|.:...|.:.
Zfish  1113 PVTVRPPHPQNLSATLPTVRMIIDVSKAACILTTQV----LTKILRSKE-----AAATVNIKTWP 1168

  Fly   163 NIYDLKELMEDEKFKTQPDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLTQMNLLATLDS-QIQP 226
            .|.|..:|..    |..|....|.  ..|.::.:..|..|||:..||:::...:.|...| ::|.
Zfish  1169 IIIDTDDLPR----KRPPTIYKPP--NAEMIAYLDFSVSTTGMLTGVKISHAAVSALCRSIKLQC 1227

  Fly   227 TVIPMEEVTL-------LTVIPWFHAFGCLTLITTACVGARLVYLPKFEEK----LFLSAIEKYR 280
            .:....::.:       |..:.|     ||..:.:   |.:.:.:|..|.:    |:|..:.:||
Zfish  1228 ELYSSRQIAICLDPYCGLGFVLW-----CLASVYS---GHQSILIPPMELETSLTLWLGTLSQYR 1284

  Fly   281 VMMAFMVPPLMVFLAK-----HPIVDKYDLSSLMVLLCGAAPLSR------ETEDQIKERIGVPF 334
            :...|....:|....|     ..::....::...|..|......|      .:..::.:.||:..
Zfish  1285 IRDTFCSYSVMELCTKGLGGQTELLKARGVNLSCVRSCVVIAEERPRLALTHSFSKLFKDIGLSM 1349

  Fly   335 --IRQGYGLSESTLSVLVQNDEFCKPGSV----------------------------GVLKVGIY 369
              :...:| |...|::.:|......|.:|                            |.:..|:.
Zfish  1350 RAVSTAFG-SRVNLAICLQGTTGPDPSTVYVDMKSLRHDRVRLVERGAPQSLPLMESGTILPGVR 1413

  Fly   370 AKVIDPDTGKLLGANERGELCFKGDGIMKGYI---------GDTKSTQTAIKDG---WLHTGDIG 422
            ..:::|:|...||.:..||:.........||.         .|..:|:.:..|.   |..||.:|
Zfish  1414 VVIVNPETRGPLGDSHLGEIWVNSPHNATGYYTIYGEENLQADHFNTKLSFGDPQTLWARTGYLG 1478

  Fly   423 YY----------DDDFEFFIVDRIKELIKYKGYQVPPAEIE--------------ALLLTNDKIK 463
            :.          |.....|:|..:.|.::.:|.:..|.:||              ....||..:.
Zfish  1479 FVKRTELTDASGDRHDALFVVGYLDETLELRGLRYHPIDIETSVSRAHRSIGESAVFTWTNLLVV 1543

  Fly   464 DAAVIGKPDEEAGELPLAFVVKQANVQLTENEVIQFVNDNASPAKRLRGGVIFVDE--IPKNPSG 526
            .|.:.|...:....:||.     .||.|.|:.:|.             |.|:.||.  ||.|..|
Zfish  1544 VAELCGSEQDALDLVPLV-----TNVVLEEHHLIV-------------GVVVIVDPGVIPINSRG 1590

  Fly   527 KILRRILRE 535
            :..|..||:
Zfish  1591 EKQRMHLRD 1599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	119/636 (19%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	111/586 (19%)
dip2bb	XP_009300851.1	DMAP_binding	9..137	CDD:283995
		Dip2	391..955	CDD:213273
		AFD_class_I	1052..1604	CDD:327384	112/591 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900