DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and dip2ba

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_009295115.1	Gene:	dip2ba / 405899	ZFINID:	ZDB-GENE-040426-2305	Length:	1587	Species:	Danio rerio

Alignment Length:	666	Identity:	134/666 - (20%)
Similarity:	235/666 - (35%)	Gaps:	186/666 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKLLPGNIVYGGPVTERQAQD---------SRSLGQYILDKYKSFGDRT-------------VLV 45
            :.::.||:|.|..:.:...:|         ||.|..:..:.::...:..             :|:
Zfish   959 ASIMVGNLVAGKRIAQASGRDLGLIDDQEQSRKLCVWPTNMHQFLSEALQWRAQTDPDHVLYMLL 1023

  Fly    46 DAVNGVEYS---ASFMHKSIVRL-AYILQKLGVKQNDVVGLSSENSVNFALAMFAGLAVG---AT 103
            :| .||..|   .|.:||...:: |.:|::.|:...|.|.|.....::...:.:..|..|   .|
Zfish  1024 NA-KGVAVSTATCSQLHKRAEKITAALLERGGINTGDNVVLLYPPGIDLIASFYGCLYAGCIPVT 1087

  Fly   104 VAPLNVTYSDREVDHAINLSKPKIIFASKITIDRVAKVASKNKFVKGI----IALSGTSKKFKNI 164
            |.|          .|..|||.........|.:.:.|.:.:....:|.:    .|.|...|.:.||
Zfish  1088 VRP----------PHPQNLSATLPTVRMIIDVSKAACILTTQTLMKTLRSKEAAASVNVKTWPNI 1142

  Fly   165 YDLKELMEDEKFKTQPDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLT---------QMNLLATL 220
            .|..:|   .:.:....:..|.|   |.::.:..|..|||:..||:::         .:.|...|
Zfish  1143 IDTDDL---PRKRPASIYKPPTA---EMLAYLDFSVSTTGMLTGVKMSHSAVNALCRSIKLQCEL 1201

  Fly   221 DSQIQPTVIPMEEVTLLTVIPWFHAFGCLTLITTACVGARLVYLPKFEEK----LFLSAIEKYRV 281
            .|..| ..|.|:....|..:.|     ||:.:.:   |.:.:.:|..|.:    |:||.:.:|::
Zfish  1202 YSSRQ-IAICMDPYCGLGFVLW-----CLSSVYS---GHQSILIPPMELETSLPLWLSTLSQYKI 1257

  Fly   282 MMAF----------------------------MVPPLMVFLAKHPIVDKYDLSSLMVLLCGAAPL 318
            ...|                            .|...:|...:.|.:......|.:....|.:|
Zfish  1258 RDTFCSYSVMELCTKGLGTQTEALKARNVNLSCVRSCVVIAEERPRLALTQSFSKLFKDLGLSP- 1321

  Fly   319 SRETEDQIKERIGVPFIRQG-YGLSESTLSV---LVQND-----EFCKPGSV-----GVLKVGIY 369
             |........|:.:....|| .|...||:.|   .:::|     |...|.|:     |.:..|:.
Zfish  1322 -RAVSTAFGSRVNLAICLQGTAGPDPSTVYVDMKSLRHDRVRLVERGAPQSLPLMESGTMLPGVR 1385

  Fly   370 AKVIDPDTGKLLGANERGELCFKGDGIMKGY-------------------IGDTKSTQTAIKDGW 415
            ..:::|:|...||.:..||:.........||                   .|||::.       |
Zfish  1386 VIIVNPETKGPLGDSHLGEIWVNSPHNASGYYTIYGEESLQADHFNTRLSFGDTETL-------W 1443

  Fly   416 LHTGDIGYY----------DDDFEFFIVDRIKELIKYKGYQVPPAEIE-ALLLTNDKIKDAAVI- 468
            ..||.:|:.          |.....|:|..:.|.::.:|.:..|.:|| ::...:..|.::||.
Zfish  1444 ARTGYLGFVKRTELLDASGDRHDALFVVGSLDETLELRGLRYHPIDIETSVSRAHRSIAESAVFT 1508

  Fly   469 ------------GKPDEEAGELPLAFVVKQANVQLTENEVIQFVNDNASPAKRLRGGVIFVDE-- 519
                        |...|....:||.     .||.|.|:.:|.             |.|:.||.
Zfish  1509 WTNLLVVVVELSGSEQEALDLVPLV-----TNVVLKEHHLIV-------------GVVVIVDPGV 1555

  Fly   520 IPKNPSGKILRRILRE 535
            ||.|..|:..|..||:
Zfish  1556 IPINSRGEKQRMHLRD 1571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	127/634 (20%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	123/596 (21%)
dip2ba	XP_009295115.1	DMAP_binding	8..124	CDD:283995
		CaiC	339..915	CDD:223395
		Dip2	363..927	CDD:213273
		AMP-binding	1007..1481	CDD:278902	99/508 (19%)
		Dip2	1024..1576	CDD:213273	125/601 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900