DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6178 and CG4563

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	148/537 - (27%)
Similarity:	255/537 - (47%)	Gaps:	26/537 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VYGGPVTERQAQDSRSLGQYILDKYKSFGDRTVLVDAVNGVEYSASFMHKSIVRLAYILQKLGVK 75
            |:.||........:.|:||.:.:..:.:....:.:...:|...:.:.|.....|:|...:..|:.
  Fly    17 VWSGPPRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIALFFKSEGLT 81

  Fly    76 QNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVTYSDRE---VDHAINLSKPKIIFASKITIDR 137
            |.|.||:.: ||..|.:.:.......||  |.:.....||   |....:::||||:|......||
  Fly    82 QEDRVGIIA-NSSTFVIPVATACFFQAT--PFHAVNYSREPAIVQGLYSVTKPKIMFIDGPDYDR 143

  Fly   138 VAKVASKNKFVKGIIALSGTSKKFKNIYDLKELMEDEKFKTQPDFTSPA--ANKDEDVSLIVCSS 200
            :.::.  .::...:|.|:|..:...:|.||.:....||...      ||  |...:.:::::|||
  Fly   144 IKEIT--KEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYV------PASLATGGDQIAVVLCSS 200

  Fly   201 GTTGLPKGVQLTQMNLLATLDSQIQPTVIPMEEVTLLTVIPWFHAFGCLTLITTACVGARLVYLP 265
            ||.||||.|.|:..::.:|....|...|:    .|..| |.|...|. :|::...|...|::...
  Fly   201 GTAGLPKAVALSHRHIASTNSLCISTDVL----YTSAT-IDWMTGFS-ITVMNLTCGFTRIISRR 259

  Fly   266 KFEEKLFLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDLSSLMVLLCGAAPLSRETEDQIKERI 330
            .|..:..|..:.||:|....|.|.....|...|:.....|.||.:.......:|.....:.:|.:
  Fly   260 TFSAETALYLVSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALLRRAQELL 324

  Fly   331 GVPFIRQGYGLSESTLSVLVQNDEFCKPGSVGVLKVGIYAKVIDPDTGKLLGANERGELCFKGDG 395
            ...::...||.:|:  .|:..|.:.....|||.|..|:..|:...| |:.||.|:.||:......
  Fly   325 PKTYVMFSYGTTET--GVVTINIDHSLECSVGRLAPGMRIKIQGED-GQQLGVNQTGEVLIDIGL 386

  Fly   396 IMKGYIGDTKSTQTAIKDGWLHTGDIGYYDDDFEFFIVDRIKELIKYKGYQVPPAEIEALLLTND 460
            ..:||:.:.:.|.|.::|||::.||:||:|:|...::|||.|:|:|||.....|.|||.::....
  Fly   387 KWEGYLSNPEDTATTLQDGWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAELP 451

  Fly   461 KIKDAAVIGKPDEEAGELPLAFVVKQANVQLTENEVIQFVNDN-ASPAKRLRGGVIFVDEIPKNP 524
            :::...|:|..|...|:...|.::|:...::.:.:||..|... ....|:|..||||||:.|||.
  Fly   452 EVEHVCVVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVDYKQLNAGVIFVDKFPKNA 516

  Fly   525 SGKILRRILREMLKKQK 541
            :||::|.:.||:.:|.|
  Fly   517 NGKVMRSLAREVFEKTK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	143/516 (28%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	137/491 (28%)
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	144/529 (27%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	137/491 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920