DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6178 and ACSM4

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001073923.1	Gene:	ACSM4 / 341392	HGNCID:	32016	Length:	580	Species:	Homo sapiens

Alignment Length:	564	Identity:	138/564 - (24%)
Similarity:	242/564 - (42%)	Gaps:	71/564 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LPGNIVYGGPVTERQAQDSRSLGQYILDKYKSFGDRTV--LVDAVNG----VEYSASFMHKSIVR 64
            ||.|..:...|.::.:|..::            |:|..  .:..|||    |::|...:.....:
Human    48 LPKNFNFAADVLDQWSQKEKT------------GERPANPALWWVNGKGDEVKWSFRELGSLSRK 100

  Fly    65 LAYILQK-LGVKQNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVTYSDREVDHAINLSKPKII 128
            .|.:|.| .|:::.|.:.:.......:.|...|.:..|....|..:..:.:::.:.:..||.|.|
Human   101 AANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCI 165

  Fly   129 FASKITIDRVAKVASKNKFVKGIIALSGTSKKFKNIYDLKELMEDEKFKTQPDFTSPAANKDEDV 193
            .||:.....|..:..:...:|..:.:|..|  :......:||     |:...:..|......::.
Human   166 VASEEVAPAVESIVLECPDLKTKLLVSPQS--WNGWLSFQEL-----FQFASEEHSCVETGSQEP 223

  Fly   194 SLIVCSSGTTGLPKGVQLTQMNL--------LATLDSQIQPTVIPMEEVTLLTVIPWFH-AFGCL 249
            ..|..:|||||.||..|.:|.:|        ...||.:....:..|.:.      .|.. |.|.:
Human   224 MTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDT------GWVKAAIGSV 282

  Fly   250 --TLITTACVGARLVY-LPKFEEKLFLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDLSSLMVL 311
              :.:..|||   .|: :.:|:...||..:..|.: .....||.:..:.....:.:|...||...
Human   283 FSSWLCGACV---FVHRMAQFDTDTFLDTLTTYPI-TTLCSPPTVYRMLVQKDLKRYKFKSLRHC 343

  Fly   312 LCGAAPLSRETEDQIKERIGVPFIRQGYGLSESTLSVLVQNDEFCKPGSVGVLKVGIYAKVIDPD 376
            |.|..||:.|..:|.:.:.|:. :.:|||.:|..:....|..:..||||:|...:....::|| :
Human   344 LTGGEPLNPEVLEQWRVQTGLE-LYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIID-E 406

  Fly   377 TGKLLGANERGEL----------CFKGDGIMKGYIGDTKSTQTAIKDGWLHTGDIGYYDDDFEFF 431
            .|.:|...:.||:          ||     ...|:.:.:.|...|:..:..|||.|..|.|..|:
Human   407 NGNVLPPGKEGEIALRLKPTRPFCF-----FSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFW 466

  Fly   432 IVDRIKELIKYKGYQVPPAEIEALLLTNDKIKDAAVIGKPDEEAGELPLAFVV-----KQANVQL 491
            .|.|..::|...||::.|.|:|:.|:.:..:.::||:..||:..||:..||||     |..|.:.
Human   467 FVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEK 531

  Fly   492 TENEVIQFVNDNASPAKRLRGGVIFVDEIPKNPSGKILRRILRE 535
            ...|:...|..:.:|.|..| .|.||.|:||..:|||.|.:||:
Human   532 LTLELQDHVKKSTAPYKYPR-KVEFVQELPKTITGKIKRNVLRD 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	133/544 (24%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	127/519 (24%)
ACSM4	NP_001073923.1	MACS_euk	48..577	CDD:213294	138/564 (24%)
ACSM4	NP_001073923.1	Acs	49..580	CDD:223442	137/563 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920