DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6178 and Acsf3

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_659181.2	Gene:	Acsf3 / 257633	MGIID:	2182591	Length:	583	Species:	Mus musculus

Alignment Length:	581	Identity:	147/581 - (25%)
Similarity:	252/581 - (43%)	Gaps:	87/581 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLPGNIVYGGPVTERQAQDSRSLGQYILDKYKSFGDRTVLVDAVNGVEYSASF-----MHKSIVR 64
            |||         |..:|....|:..:|  :..:||||..|:|......|...:     :.:.|.|
Mouse    31 LLP---------TTPEAHTDGSVPVFI--RALAFGDRIALIDKYGHHTYRELYDRSLCLAQEICR 84

  Fly    65 LAYILQKLGVKQNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVTYSDREVDHAINLSKPKIIF 129
            |...  |:|..|.:.|.....|.|::.:|.:|....|....||...:.:.::::.|..|:..::.
Mouse    85 LQGC--KVGDLQEERVSFLCSNDVSYVVAQWASWMSGGVAVPLYWKHPEAQLEYFIQDSRSSLVV 147

  Fly   130 ASKITIDRVAKVASKNKFVKGIIALSGTSKKFKNIYDLKELMEDEKFKTQPDFTSPAANKDEDVS 194
            ..:..::|::.:|.:    .|:..|..|...:..        ..||...||  ...:..:|.. :
Mouse   148 VGQEYLERLSPLAQR----LGVPLLPLTPAVYHG--------ATEKPTEQP--VEESGWRDRG-A 197

  Fly   195 LIVCSSGTTGLPKGVQLTQMNLLATLDSQIQPTVIPMEEVTLLTVIPWFHAFGCLT-LITTACVG 258
            :|..:|||||.|||...|..||.|.:...:........:| :|.|:|..|..|.:. |:....||
Mouse   198 MIFYTSGTTGRPKGALSTHRNLAAVVTGLVHSWAWTKNDV-ILHVLPLHHVHGVVNKLLCPLWVG 261

  Fly   259 ARLVYLPKFEEKLFLSAIEKYRVMMAFMVPPLMVFLA----KHPIVDKYD--------------- 304
            |..|.||:|      ||.:.:...::...|.:.||:|    ...::|.||
Mouse   262 ATCVMLPEF------SAQQVWEKFLSSEAPQITVFMAVPTVYSKLLDYYDKHFTQPHVQDFVRAV 320

  Fly   305 -LSSLMVLLCGAAPLSRETEDQIKERIGVPFIRQGYGLSESTLSVLVQNDEFCKPGSVGVLKVGI 368
             ...:.:::.|:|.|.....::.:...|...:.: ||::|..:::.....|...|||||....|:
Mouse   321 CKERIRLMVSGSAALPVPLLEKWRSATGHTLLER-YGMTEIGMALSNPLTEARVPGSVGTPLPGV 384

  Fly   369 YAKVI--DPDTGK--LLGA--NER------------GELCFKGDGIMKGYIGDTKSTQTAI-KDG 414
            ..::|  :|..|.  ::.|  |||            |||..:|..:.:.|....:.|::|. .||
Mouse   385 EVRIISENPQKGSPYIIHAEGNERGTKVTPGFEEKEGELLVRGPSVFREYWDKPEETKSAFTSDG 449

  Fly   415 WLHTGDIGYYDDDFEFFIVDRIK-ELIKYKGYQVPPAEIEALLLTNDKIKDAAVIGKPDEEAGEL 478
            |..|||...: .|..::|..|.. ::||..||:|...|||..||.:..|.|.||||.||...|:.
Mouse   450 WFRTGDTAVF-KDARYWIRGRTSVDIIKTGGYKVSALEIERHLLAHPSITDVAVIGVPDMTWGQR 513

  Fly   479 PLAFVVKQANVQLTENEVIQFVNDNASPAKRLRGGVIFVDEIPKNPSGKILRRILREMLKK 539
            ..|.|..|....|:..::.::.....:| ..:...::.|:|||:|..||:.:   :|:||:
Mouse   514 VTAVVALQEGHSLSHGDLKEWARGVLAP-YAVPSELLLVEEIPRNQMGKVNK---KELLKQ 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	140/556 (25%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	133/531 (25%)
Acsf3	NP_659181.2	MCS	55..569	CDD:341264	136/543 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810