DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and Acsm4

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_848501.1	Gene:	Acsm4 / 233801	MGIID:	2681844	Length:	580	Species:	Mus musculus

Alignment Length:	565	Identity:	147/565 - (26%)
Similarity:	251/565 - (44%)	Gaps:	69/565 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KLLPGNIVYGGPVTERQAQDSRSLGQYILDKYKSFGDRTV--LVDAVNG----VEYSASFMHKSI 62
            |.||.|..:...|          |.|:.| |.|| |:|..  .:..|||    |::|...:....
Mouse    46 KPLPKNFNFAADV----------LDQWSL-KEKS-GERPANPALWWVNGKGDEVKWSFQELGSLS 98

  Fly    63 VRLAYILQK-LGVKQNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVTYSDREVDHAINLSKPK 126
            .:.|.:|.| .|:::.|.|.:.......:.|...|.:..|....|..:..:.:::.:.:..||.|
Mouse    99 RKAANVLTKPCGLQRGDRVAVILPRIPEWWLINVACMRTGLVFMPGTIQLTRKDILYRLQASKAK 163

  Fly   127 IIFASKITIDRVAKVASKNKFVKGIIALS-----GTSKKFKNIYDLKELMEDEKFKTQPDFTSPA 186
            .|.||:.....|..:.|:...:|..:.:|     |    :.|..:|.:...:|....:.....|.
Mouse   164 CIVASEEVAPAVDSIVSECPSLKTKLLVSPHHWDG----WLNFQELLQSASEEHNCVETGSQEPM 224

  Fly   187 ANKDEDVSLIVCSSGTTGLPKGVQLTQ--MNLLATLDSQIQPTVIPMEEVTLLTVIPWFH-AFGC 248
            |        |..:|||||.||..|.:|  :.:..||..:....:...:.:..::...|.. |.|.
Mouse   225 A--------IYFTSGTTGSPKMAQHSQGSLGIGYTLCGRYWLDLTSSDIMWNMSDTGWIKAAIGS 281

  Fly   249 L--TLITTACVGARLVY-LPKFEEKLFLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDLSSLMV 310
            :  |.:..|||   .|: :.:|:..:||..:..|.:......|.:...|.:..: .:|....|..
Mouse   282 VFSTWLRGACV---FVHRMAQFDTDIFLDTLTTYPITTLCSAPTVYRMLVQKDL-KRYQFKRLRH 342

  Fly   311 LLCGAAPLSRETEDQIKERIGVPFIRQGYGLSESTLSVLVQNDEFCKPGSVGVLKVGIYAKVIDP 375
            .|.|..||:.|..:|.|.:.|:. :.:|||.:|..:....:..|..||||:|...|....::||
Mouse   343 CLTGGEPLNPEVLEQWKMQTGLE-LYEGYGQTEVGIICANRKGEAIKPGSMGKGVVPYDVQIID- 405

  Fly   376 DTGKLLGANERGEL----------CFKGDGIMKGYIGDTKSTQTAIKDGWLHTGDIGYYDDDFEF 430
            :.|.:|.:.:.||:          ||..:     |:.:.:.|...|:..:..|||.|..|||..|
Mouse   406 ENGNILPSGKEGEIALRLKSDRPFCFFSE-----YVDNPEKTDATIRRNFYVTGDRGVMDDDGYF 465

  Fly   431 FIVDRIKELIKYKGYQVPPAEIEALLLTNDKIKDAAVIGKPDEEAGELPLAFVV-----KQANVQ 490
            :.|.|..::|...||::.|.|:|:.|:.:..:.::||:..||...||:..||:|     |.:|.:
Mouse   466 WFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFIVLAAPYKCSNRE 530

  Fly   491 LTENEVIQFVNDNASPAKRLRGGVIFVDEIPKNPSGKILRRILRE 535
            ....|:...|.::.:|.|..| .|.||.|:||..:|||.|.:||:
Mouse   531 KLTAELQDHVKNSTAPYKYPR-KVEFVQELPKTITGKIKRNVLRD 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	142/543 (26%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	130/518 (25%)
Acsm4	NP_848501.1	MACS_euk	48..577	CDD:213294	146/563 (26%)
Acsm4	NP_848501.1	Acs	49..576	CDD:223442	145/562 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920