DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and DIP2A

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_011527794.1	Gene:	DIP2A / 23181	HGNCID:	17217	Length:	1607	Species:	Homo sapiens

Alignment Length:	654	Identity:	130/654 - (19%)
Similarity:	234/654 - (35%)	Gaps:	170/654 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKLLPGNIVYGGPVTERQAQDSRSLGQ--------YILDKYKSFGDRT------VLVDAVNGVEY 53
            :.::.||:|.|..:.:...::...|..        ::.|..:.....|      :|::|...|..
Human   987 ASMIVGNLVAGKRIAQASGRELAHLEDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTS 1051

  Fly    54 SASF--MHKSIVRLAYILQKLG-VKQNDVVGLSSENSVNFALAMFAGLAVG---ATVA---PLNV 109
            :|:.  :||...|:|..|.:.| :...|.|.|.....|:...|.:..|..|   .||.   |.|:
Human  1052 TATCVQLHKRAERVAAALMEKGRLSVGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNL 1116

  Fly   110 TYSDREVDHAINLSKPKIIFASKITIDRVAKVASKNKFVKGIIALSGTSKKFKNIYDLKELMEDE 174
            ..:...|...:.:||.    |..:|...|.::....:     .|.:...:.:..|.|..::   .
Human  1117 GTTLPTVKMIVEVSKS----ACVLTTQAVTRLLRSKE-----AAAAVDIRTWPTILDTDDI---P 1169

  Fly   175 KFKTQPDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLTQMNLLATLDS-QIQPTVIPMEEVTLLT 238
            |.|....|..|:   .:.::.:..|..|||:..||:::.....|...| ::|..:.|..::. :.
Human  1170 KKKIASVFRPPS---PDVLAYLDFSVSTTGILAGVKMSHAATSALCRSIKLQCELYPSRQIA-IC 1230

  Fly   239 VIPWF---HAFGCLTLITTACVGARLVYLPKFE----EKLFLSAIEKYRVMMAF----------- 285
            :.|:.   .|..||..:.:   |.:.|.:|..|    ..|:|||:.:|:..:.|
Human  1231 LDPYCGLGFALWCLCSVYS---GHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTK 1292

  Fly   286 -----------------MVPPLMVFLAKHP-IVDKYDLSSLMVLLCGAAPLSRETEDQIKERIGV 332
                             .|...||...:.| |......|.|...|  ..| :|........|:.|
Human  1293 GLGAQTGVLRMKGVNLSCVRTCMVVAEERPRIALTQSFSKLFKDL--GLP-ARAVSTTFGCRVNV 1354

  Fly   333 PFIRQG-YGLSESTLSV---LVQND-----EFCKPGSV-----GVLKVGIYAKVIDPDTGKLLGA 383
            ....|| .|...:|:.|   .:::|     |...|.|:     |.:..|:...:...:|...||.
Human  1355 AICLQGTAGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVKVIIAHTETKGPLGD 1419

  Fly   384 NERGELCFKGDGIMKGY-------------------IGDTKSTQTAIKDGWLHTGDIGY------ 423
            :..||:.........||                   .|||::.       |..||.:|:
Human  1420 SHLGEIWVSSPHNATGYYTVYGEEALHADHFSARLSFGDTQTI-------WARTGYLGFLRRTEL 1477

  Fly   424 -------YDDDFEFFIVDRIKELIKYKGYQVPPAEIE-ALLLTNDKIKDAAV------------I 468
                   :|   ..::|..:.|.::.:|.:..|.:|| :::..:..|.:.||            :
Human  1478 TDASGGRHD---ALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVEL 1539

  Fly   469 GKPDEEAGELPLAFVVKQANVQLTENEVIQFVNDNASPAKRLRGGVIFVDE--IPKNPSGKILRR 531
            ...:::|    |..|....||.|.|:.::.             |.|:.||.  ||.|..|:..|.
Human  1540 DGLEQDA----LDLVALVTNVVLEEHYLVV-------------GVVVIVDPGVIPINSRGEKQRM 1587

  Fly   532 ILRE 535
            .||:
Human  1588 HLRD 1591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	126/631 (20%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	120/592 (20%)
DIP2A	XP_011527794.1	DMAP_binding	9..158	CDD:283995
		CaiC	360..959	CDD:223395
		AFD_class_I	392..956	CDD:302604
		AMP-binding	1027..1501	CDD:278902	99/505 (20%)
		AFD_class_I	1044..1596	CDD:302604	122/597 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900