DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6178 and DIP2C

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_011517730.1	Gene:	DIP2C / 22982	HGNCID:	29150	Length:	1626	Species:	Homo sapiens

Alignment Length:	675	Identity:	134/675 - (19%)
Similarity:	234/675 - (34%)	Gaps:	202/675 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKLLPGNIVYGGPVTERQAQDS-RSLGQ--------------------------YILDKYKSFGD 40
            :.::.||:|.|    :|.||.| |.|||                          :||  |.....
Human   996 ASVMVGNLVSG----KRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHIL--YTLLNC 1054

  Fly    41 RTVLVDAVNGVEYSASFMHKSIVRLAYILQKLG-VKQNDVVGLSSENSVNFALAMFAGLAVGA-- 102
            |..:.:::..|:     :||...::|.:|.:.| ::..|.|.|.....::...|.:..|..|.
Human  1055 RGAIANSLTCVQ-----LHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVP 1114

  Fly   103 -TVA---PLNVTYSDREVDHAINLSKPKIIFASKITIDRVAKVASKNKFVKGIIALSGTSKKFKN 163
             ||.   |.|:..:...|...:.:|:.    |..:|...:.|:....:....:
Human  1115 ITVRPPHPQNIATTLPTVKMIVEVSRS----ACLMTTQLICKLLRSREAAAAV------------ 1163

  Fly   164 IYDLKE----LMEDEKFKTQPDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLTQMNLLATLDS-Q 223
              |::.    |..|:..|.:|.......|.| .::.:..|..|||:..||:::.....|...| :
Human  1164 --DVRTWPLILDTDDLPKKRPAQICKPCNPD-TLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIK 1225

  Fly   224 IQPTVIPMEEVTL-------LTVIPWFHAFGCLTLITTACVGARLVYLPKFE----EKLFLSAIE 277
            :|..:.|..||.:       |..:.|     ||..:.:   |.:.:.:|..|    ..|:|.|:.
Human  1226 LQCELYPSREVAICLDPYCGLGFVLW-----CLCSVYS---GHQSILIPPSELETNPALWLLAVS 1282

  Fly   278 KYRVMMAF----------------------------MVPPLMVFLAKHPIVDKYDLSSLMVLLCG 314
            :|:|...|                            .|...:|...:.|.:......|.:....|
Human  1283 QYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLG 1347

  Fly   315 AAPLSRETEDQIKERIGV--------PFIRQG-YGLSESTLSV---LVQND-----EFCKPGSV- 361
            ..|.:..|....:..:.:        ....|| .|...:|:.|   .:::|     |...|.|:
Human  1348 LHPRAVSTSFGCRVNLAICLQPHRLWTLAEQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLP 1412

  Fly   362 ----GVLKVGIYAKVIDPDTGKLLGANERGELCFKGDGIMKGYI---GDTK-------------S 406
                |.:..|:...:.:|:|...||.:..||:.........||.   ||..             .
Human  1413 LMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGD 1477

  Fly   407 TQTAIKDGWLHTGDIGYY------DDDFE----FFIVDRIKELIKYKGYQVPPAEIE-ALLLTND 460
            |||.    |..||.:|:.      |.:.|    .::|..:.|.::.:|.:..|.:|| :::..:.
Human  1478 TQTI----WARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHK 1538

  Fly   461 KIKDAAVI-------------GKPDEEAGELPLAFVVKQANVQLTENEVIQFVNDNASPAKRLRG 512
            .:.:.||.             |...|....:||.     .||.|.|:.:|.             |
Human  1539 SVTECAVFTWTNLLVVVVELDGSEQEALDLVPLV-----TNVVLEEHYLIV-------------G 1585

  Fly   513 GVIFVD--EIPKNPSGKILRRILRE 535
            .|:.||  .||.|..|:..|..||:
Human  1586 VVVVVDIGVIPINSRGEKQRMHLRD 1610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	125/651 (19%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	115/600 (19%)
DIP2C	XP_011517730.1	DMAP_binding	<32..180	CDD:283995
		CaiC	377..968	CDD:223395
		Dip2	401..965	CDD:213273
		AMP-binding	1036..1520	CDD:278902	96/521 (18%)
		AFD_class_I	1053..1615	CDD:302604	119/612 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900