Protein Alignment CG6178 and ACSF3

DIOPT Version :10

• Sequence 1: NP_651221.1
• Gene: CG6178 / 42867
• FlyBaseID: FBgn0039156
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_777577.2
• Gene: ACSF3 / 197322
• HGNCID: 27288
• Length: 576
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 140/589 - (23%)
• Similarity: 244/589 - (41%)
• Gaps: 115/589 - (19%)

  Fly    10 IVYGGPVTERQAQDSRSLGQYILDKYKSFGDRTVLVDAVNGVEYSASFMHKSIVRLAYILQKL-- 72
            :::..||    |:..||..  :..:..:||||..|||......|..  ::...:||:..:.:|
Human    31 LLHTAPV----ARSDRSAP--VFTRALAFGDRIALVDQHGRHTYRE--LYSRSLRLSQEICRLCG 87

  Fly    73 ---GVKQNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVTYSDREVDHAINLSKPKIIFASKIT 134
               |..:.:.|.....|..::.:|.:|....|....||...:...::::.|..|:..::.||:..
Human    88 CVGGDLREERVSFLCANDASYVVAQWASWMSGGVAVPLYRKHPAAQLEYVICDSQSSVVLASQEY 152

  Fly   135 IDRVAKVASKNKFVKGIIALSGTSKKFKNIYDLKELMEDEKFKTQPDFTSPAANKDEDV------ 193
            ::.::.|..|    .|:..|..|                      |...:.|..:..:|
Human   153 LELLSPVVRK----LGVPLLPLT----------------------PAIYTGAVEEPAEVPVPEQG 191

  Fly   194 -----SLIVCSSGTTGLPKGVQLTQMNLLATLDSQIQPTVIPMEEVTLLTVIPWFHAFGCL-TLI 252
                 ::|:.:|||||.||||..|..|:.|.:...:.......::| :|.|:|..|..|.: .|:
Human   192 WRNKGAMIIYTSGTTGRPKGVLSTHQNIRAVVTGLVHKWAWTKDDV-ILHVLPLHHVHGVVNALL 255

  Fly   253 TTACVGARLVYLPKFE-----EKLFLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDL------- 305
            ....|||..|.:|:|.     ||...|...:..|.||  ||.:...|.::     ||.
Human   256 CPLWVGATCVMMPEFSPQQVWEKFLSSETPRINVFMA--VPTIYTKLMEY-----YDRHFTQPHA 313

  Fly   306 ---------SSLMVLLCGAAPLSRETEDQIKERIGVPFIRQGYGLSE------STLSVLVQNDEF 355
                     ..:.:::.|:|.|.....::.|...|...:.: ||::|      ..|:..|:
Human   314 QDFLRAVCEEKIRLMVSGSAALPLPVLEKWKNITGHTLLER-YGMTEIGMALSGPLTTAVR---- 373

  Fly   356 CKPGSVGVLKVGIYAKVIDPD------------------TGKLLGANER-GELCFKGDGIMKGYI 401
             .|||||....|:..:::..:                  |....|..|: |||..:|..:.:.|.
Human   374 -LPGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKVTPGFEEKEGELLVRGPSVFREYW 437

  Fly   402 GDTKSTQTAIK-DGWLHTGDIGYYDDDFEFFIVDRIK-ELIKYKGYQVPPAEIEALLLTNDKIKD 464
            ...:.|::|.. |||..|||...:.|. :::|..|.. ::||..||:|...|:|..||.:..|.|
Human   438 NKPEETKSAFTLDGWFKTGDTVVFKDG-QYWIRGRTSVDIIKTGGYKVSALEVEWHLLAHPSITD 501

  Fly   465 AAVIGKPDEEAGELPLAFVVKQANVQLTENEVIQFVNDNASPAKRLRGGVIFVDEIPKNPSGKIL 529
            .||||.||...|:...|.|..:....|:..|:.::..:..:| ..:...::.|:|||:|..|||.
Human   502 VAVIGVPDMTWGQRVTAVVTLREGHSLSHRELKEWARNVLAP-YAVPSELVLVEEIPRNQMGKID 565

  Fly   530 RRIL 533
            ::.|
Human   566 KKAL 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	Adenylate forming domain, Class I superfamily	9..536	CDD:473059	140/589 (24%)
ACSF3	NP_777577.2	MCS	55..571	CDD:341264	133/559 (24%)