DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6178 and acs-9

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_510728.2	Gene:	acs-9 / 188659	WormBaseID:	WBGene00020634	Length:	497	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	161/533 - (30%)
Similarity:	253/533 - (47%)	Gaps:	71/533 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ILDKYKSFGDRTVLVDAVNGVEYSASFMHKSIVRLAYILQKLGVKQNDVVGLSSENSVNFALAMF 95
            ||:....||.|..||.....:.:..  :.:.:.:|.|.|.:||:.|.|.:.:...||:.:.|...
Worm    14 ILENVVKFGIRQALVHDNQVITFEE--IPQLVSKLVYKLLELGISQGDTILVCLPNSIWYPLLFL 76

  Fly    96 AGLAVGATVAPLNVTYSDREVDHAINLSKPKIIFASKITIDRVAKVASKNKFVKGIIALSGTSKK 160
            :...:||.::.::...:..|:.:::..|..|::|.::       ||:.:|.:     |||..|
Worm    77 SCAKIGAVLSGISHESTAGEIKYSLKQSGAKLVFTNE-------KVSKENYW-----ALSENS-- 127

  Fly   161 FKNIYDLKELMED------EKFKTQPDFTSPAANKDED-VSLIVCSSGTTGLPKGVQLTQMNLLA 218
                   .|::.|      ::.....||.  ..|.|.| :.|...||||||.||...||..|.||
Worm   128 -------VEVLPDSVKTYIDRITGHEDFR--PENLDIDSILLAPFSSGTTGAPKCCLLTHRNFLA 183

  Fly   219 ---TLDSQIQPTVIPMEEVTLLTVIPWFHAFGCLTLITTACVGARLVYLPKFEEKLFLSAIEKYR 280
               :|...:...::....:..|..:|:.||.|...|:.....|.....:.:|...:.:..||||.
Worm   184 ATYSLKKFLFDQLLAQSSMKTLAFLPFHHASGFWALLICLLEGCTTYIMSEFHPIVMMDLIEKYE 248

  Fly   281 VMMAFMVPPLMVFLAKHPIVDKYDLSSLMVLLCGAAPLSRETEDQIKERIGV-----PFIRQGYG 340
            :....:|||:.....|..|: :....||..:|||::.|.:   |:.|..:.:     .|| ||||
Worm   249 IDTINIVPPIANIFLKMGIL-QGRCPSLRTILCGSSGLQK---DRCKRLLSIFPQVTHFI-QGYG 308

  Fly   341 LSESTLSVLVQ--NDEFCKPGSVGVLKVGIYAKVIDPDTGKLLGANERGELCFKGDGIMKGYIGD 403
            ::|..:...|.  :|.|...||.|.:..|...|:.:..||:.       ||..|.|.|||.|...
Worm   309 MTELVVLSCVTPFDDNFEHLGSCGHILPGFETKLFEHPTGET-------ELWLKSDAIMKAYKNG 366

  Fly   404 TKSTQTAIKDGWLHTGDIGYYDDDFEFFIVDRIKELIKYKGYQVPPAEIEALLLTNDKIKDAAVI 468
            |.:..   :|.|||||||......| |::|||:|:|||..||||.|.|||.::||..|:.:.||:
Worm   367 TPNLD---EDDWLHTGDIVTEKGGF-FYVVDRMKDLIKLNGYQVSPTEIENVILTLPKVAEVAVV 427

  Fly   469 GKPDEEAGELPLAFVV--KQANVQLTENEVIQFVNDNASPAKRLRGGVIFVDEIPKNPSGKILRR 531
            |..||..|:||.|::|  |.|:..|....:...:.:..|..|:|||||..:.|:||:.||||
Worm   428 GIEDELCGQLPKAYIVLEKNADELLFLKHLEHTMKEKLSAVKQLRGGVSIIKEMPKSSSGKI--- 489

  Fly   532 ILREMLKKQKSKL 544
                    ||::|
Worm   490 --------QKNRL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	158/524 (30%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	152/504 (30%)
acs-9	NP_510728.2	CaiC	1..494	CDD:223395	160/531 (30%)
acs-9	NP_510728.2	Firefly_Luc_like	26..490	CDD:213279	153/515 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54045
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	1	1.000	-	-		FOG0000951
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930