Protein Alignment CG6178 and mec-18

DIOPT Version :10

• Sequence 1: NP_651221.1
• Gene: CG6178 / 42867
• FlyBaseID: FBgn0039156
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_508731.3
• Gene: mec-18 / 180701
• WormBaseID: WBGene00003179
• Length: 638
• Species: Caenorhabditis elegans
• Alignment Length: 590
• Identity: 151/590 - (25%)
• Similarity: 266/590 - (45%)
• Gaps: 84/590 - (14%)

  Fly    24 SRSLGQYILDKYKSFGDRTVLVDAVNGVEYSASFMHKSIVRLAYILQKLGVKQNDVVGLSSENSV 88
            ::|...|...|..:.|....:||..:|.::..|.:.......|..|::|.|.....|.:.:..:
 Worm    16 AQSFHDYFFSKISAHGSNLAIVDVDSGKQWRYSEIRNWCEMCATRLKELQVTSGSRVAVITGTT- 79

  Fly    89 NFALAMFAGLA---VGATVAPLNVTYSDREVDHAINLSK-------------------------- 124
              ..|:|..||   :|.:...:|...:..|:...::||:
 Worm    80 --GQAIFVHLACSIIGCSAVAVNGWNAVDEIWTLVDLSEATHLIVENQFMQKADDVRRKAQMRGG 142

  Fly   125 ---------PKIIFASKITIDRVAK----VASKNKFVK----------------------GIIAL 154
                     ..::.|.:|.:|...|    |..|...||                      .:..:
 Worm   143 GRIKHVRQIEDVLTAERINVDSARKRSIDVKQKPPLVKEMSLAKINLTPVLPEDIADLTSPVSEV 207

  Fly   155 SGTSKKFKNIYDLKELMEDEKFKTQPDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLTQMNLLAT 219
            ||.||:.....: ..:::.|:.:|.....|     .::..||:.:||||||.|..:|:..:|:..
 Worm   208 SGQSKELNGDVE-SSVVDSEEVQTPIQQVS-----GQNPLLILFTSGTTGLAKAAELSHRSLIIN 266

  Fly   220 LDSQIQPTVIPME-EVTLLTVIPWFHAFGCLTLITTACVGARLVYLPKFEEKLFLSAIEKYRVMM 283
            :.....|...|:: :...|..:...|.:|.::.......||.|..:.|...:||:..:...::.:
 Worm   267 IQQISLPLYGPVQTKERFLLPLSIAHIYGIVSAYYALINGASLYLISKQSNRLFMETLVNNQINV 331

  Fly   284 AFMVPPLMVFLAKHPIVDKYDLSSLMVLLCGAAPLSRETEDQIKERIGVPFIRQGYGLSE----S 344
            ..:.|.::.::|...|||.|...:|..:||..||:...:...:|.|:.:...||.:|::|    .
 Worm   332 MHITPAIVHWMATDAIVDDYKTPNLRSVLCAGAPIDSNSAAAMKSRLNIKDFRQSFGMTELGGIC 396

  Fly   345 TLSVLVQNDEFCKPGSVGVLKVGIYAKVIDPDTGKLLGANERGELCFKGDGIMKGYIGDTKSTQT 409
            |:|..:  ||  |..|||....|:..||::.:|.:|....:.|::...|..:...|..:.|:|..
 Worm   397 TMSPYL--DE--KIESVGNPLPGMLFKVVNWETKQLCLPRQPGQIIVLGPQVSPCYYKNPKATSE 457

  Fly   410 AI-KDGWLHTGDIGYYDDDFEFFIVDRIKELIKYKGYQVPPAEIEALLLTNDKIKDAAVIGKPDE 473
            .. ..|::.|||.|:||:....:::||||::||.||..:.|:|:|.:|..:..|.|.||:|:.|.
 Worm   458 LFDATGFVKTGDAGFYDEVGRIYVLDRIKDIIKCKGTMICPSEVELVLRAHAGIDDCAVVGRQDH 522

  Fly   474 EAGELPLAFVVKQA-NVQLTENEVIQFVNDNASPAKRLRGGVIFVDEIPKNPSGKILRRILREML 537
            ..||:|.|||||.| :..|...||.|:|:...:..|.|||||.|:.|||::..||||||.||:..
 Worm   523 VTGEVPAAFVVKNAQHPLLASAEVRQYVSGKIATFKELRGGVFFISEIPRSVCGKILRRNLRQFW 587

  Fly   538 KKQKS 542
            .::::
 Worm   588 DRERT 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	Adenylate forming domain, Class I superfamily	9..536	CDD:473059	151/582 (26%)
mec-18	NP_508731.3	Firefly_Luc_like	35..579	CDD:341237	141/556 (25%)