DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and acs-1

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001023937.1	Gene:	acs-1 / 179043	WormBaseID:	WBGene00018488	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	139/554 - (25%)
Similarity:	232/554 - (41%)	Gaps:	81/554 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DRTVLVDAVNGVEYSASFMHKSIVRLAYILQKLGVKQNDVVGLSSENSVNFALAMFAGLAVGATV 104
            |:..|:....|:..:.|.:......||..|..||:|:.|.:|:...|:..:....||....|..:
Worm    81 DKEFLIFKREGIRKTYSQVATDAENLACGLLHLGLKKGDRIGIWGPNTYEWTTTQFASALAGMVL 145

  Fly   105 APLNVTYSDREVDHAINLSKPKIIFASKIT-------------IDRVAKVASKNKFVKGIIALSG 156
            ..:|.:|...|:.:||.    |:...:.||             .|.:.:|..|.....||
Worm   146 VNINPSYQSEELRYAIE----KVGIRALITPPGFKKSNYYQSIKDILPEVTLKEPGKSGI----- 201

  Fly   157 TSKKFKNIYDLKELMEDEKFKTQP------DFTSPAANKDE------------DVSL-IVCSSGT 202
            ||:.|.....|  :|.||:.|..|      |.......:|.            |.|| |..:|||
Worm   202 TSRNFTCFQHL--IMFDEEDKIYPGAWKYTDVMKMGTEEDRHHLSKIERETQPDDSLNIQYTSGT 264

  Fly   203 TGLPKGVQLTQMNLL-----ATLDSQIQPTVIPMEEVTLLTV-IPWFHAFGCLTLITTACVGARL 261
            ||.|||..||..|:|     ..|.:...      |:.|::.: .|.:|.|||:..:..|     |
Worm   265 TGQPKGATLTHHNVLNNAFFVGLRAGYS------EKKTIICIPNPLYHCFGCVMGVLAA-----L 318

  Fly   262 VYL-------PKFEEKLFLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDLSSLMVLLCGAAPLS 319
            .:|       |.|:....|.||.:.:....:..|.:.:.:..||....|:..|:.......||..
Worm   319 THLQTCVFPAPSFDALAALQAIHEEKCTALYGTPTMFIDMINHPEYANYNYDSIRSGFIAGAPCP 383

  Fly   320 RETEDQIKERIGVPFIRQGYGLSE-STLSVLVQNDEFCKP----GSVGVLKVGIYAKVIDPDTGK 379
            .....::.:.:.:..::..||.:| |.:|.:...|:  .|    .|||.:...:.|.::| ....
Worm   384 ITLCRRLVQDMHMTDMQVCYGTTETSPVSFMSTRDD--PPEQRIKSVGHIMDHLEAAIVD-KRNC 445

  Fly   380 LLGANERGELCFKGDGIMKGYIGDTKSTQTAI-KDGWLHTGDIGYYDDDFEFFIVDRIKELIKYK 443
            ::....:||:..:|..:|:.|....:.|:..| :|.|.|||||....|:....||.|.|::|...
Worm   446 IVPRGVKGEVIVRGYSVMRCYWNSEEQTKKEITQDRWYHTGDIAVMHDNGTISIVGRSKDMIVRG 510

  Fly   444 GYQVPPAEIEALLLTNDKIKDAAVIGKPDEEAGELPLAFV--VKQANVQLTENEVIQFVNDNASP 506
            |..:.|.|:|..|..:..::|..::|.|||..||:..|:|  .:.|..:.||.::..:.....:.
Worm   511 GENIYPTEVEQFLFKHQSVEDVHIVGVPDERFGEVVCAWVRLHESAEGKTTEEDIKAWCKGKIAH 575

  Fly   507 AKRLRGGVIFVD--EIPKNPSGKILRRILREMLK 538
            .|..| .::|..  |.|...:||:.:..:|||.|
Worm   576 FKIPR-YILFKKEYEFPLTVTGKVKKFEIREMSK 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	137/551 (25%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	134/540 (25%)
acs-1	NP_001023937.1	PRK08315	53..615	CDD:236236	139/554 (25%)
acs-1	NP_001023937.1	FACL_like_2	252..604	CDD:213284	95/366 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810