DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and acs-21

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_503845.1	Gene:	acs-21 / 178751	WormBaseID:	WBGene00016849	Length:	517	Species:	Caenorhabditis elegans

Alignment Length:	512	Identity:	127/512 - (24%)
Similarity:	223/512 - (43%)	Gaps:	48/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RTVLVDAVNGVEYSASFMHKSIVRLAYILQKLGVKQNDVVGLSSENSVNFALAMFAGLAVGATVA 105
            :.:.:|....:.| ..|:.::......:.:|..:|:.|.|......:.:.|....|.|.:||...
Worm    38 KVLFIDDGRKITY-GDFVQRAGQYATALTEKYKIKKGDRVMARVSKTTDTAALYAACLQIGALYV 101

  Fly   106 PLNVTYSDREVDHAINLSKPKIIFASKITIDRVAKVASKNKFVKGIIALSGTSKKFKNIYDL--K 168
            |:|...:..|..|.:..:||.:....|...|::|..   .:.:|.:.        ..|..::  :
Worm   102 PVNPALTQSEAAHYVKDAKPSLWITCKDDADQIAMF---QRVLKTVC--------IDNPVEVINE 155

  Fly   169 ELMEDEKFKTQPDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLTQMNLLATLDSQIQPTVIPMEE 233
            :::.||..|.:.........| .:.:.|..:|||||.|||..|:...|....::.:|.......:
Worm   156 KVLADEAGKRKACTMIEHVEK-SNAATICFTSGTTGAPKGAVLSHGALTNNTNALVQEWGFTEND 219

  Fly   234 VTLLTVIPWFHAFGC-LTLITTACVGARLVYLPKFEEKLFLSAIEKYRVMMAFMVPPLMVFLAKH 297
            |. |..:|.|||.|. .:|..:....:.:::.|.|:.:.....::...|.|.  ||.....|...
Worm   220 VN-LHCLPIFHAHGLYFSLHCSLFSHSSVIWRPNFDAEDCSKHLKNATVFMG--VPTFYSRLLAT 281

  Fly   298 PIVDKYDLSSLMVLLCGAAPLSRETEDQIKERIGVPFIRQGYGLSESTLSVLVQN--DEFCKPGS 360
            ...:|.....:.:.:.|:||||..|.::.::|.| ..|.:.||::|:  .|:..|  ....|.|:
Worm   282 NNFNKESFEKIRLFISGSAPLSVPTLEEFEKRTG-QVILERYGMTEA--GVIASNPLKGKRKAGT 343

  Fly   361 VGVLKVGIYAKVIDPDTGKLLGANERGELCFKGDGIMKGYIGDTKSTQTAI-KDGWLHTGDIGYY 424
            ||....|:..:|           .|.||:..|.|.|...|..:.:.|:... :|||..|||:|..
Worm   344 VGQALKGVQCRV-----------TENGEIEIKSDSIFSEYWKNPEKTKEEFTEDGWFKTGDVGSL 397

  Fly   425 DDDFEFFIVDRIKELIKYKGYQVPPAEIEALLLTNDKIKDAAVIGKPDEEAGELPLAFVVKQANV 489
            |.|....|..|.|::|...|..:.|.|||..:.:.:.:|::|||..|..:.||..:|.||.:..|
Worm   398 DKDGYLTIGGRSKDMIISGGENIYPKEIEDAIDSIEFVKESAVIAAPHPDFGEAVVAVVVPKNMV 462

  Fly   490 ---QLTENEVIQFVNDNAS----PAKRLRGGVIFVDEIPKNPSGKILRRILREMLKK 539
               |..|.::|:.:....:    |.|     ||.::|:|:|...|:.:.|||....|
Worm   463 EDEQKFEEDLIEMLRKKLAKYKVPKK-----VILLEELPRNHITKVRKDILRASYNK 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	126/508 (25%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	123/498 (25%)
acs-21	NP_503845.1	MCS	38..505	CDD:213307	123/501 (25%)
acs-21	NP_503845.1	PRK07514	40..517	CDD:181011	127/510 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3623
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760