DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and acs-6

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_495450.1	Gene:	acs-6 / 174156	WormBaseID:	WBGene00022849	Length:	565	Species:	Caenorhabditis elegans

Alignment Length:	507	Identity:	171/507 - (33%)
Similarity:	265/507 - (52%)	Gaps:	50/507 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LAYILQKLGVKQNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVTYSDREVDHAINLSKPKIIF 129
            ||..|.|||.|..||...:..|...|.:||.|.:..|..::..:..::|.|:......|...|:|
Worm    60 LATALVKLGFKPGDVASQAFPNCPEFLVAMLAVMKCGGAMSNASAIFTDYELQLQFCDSNTSIVF 124

  Fly   130 ASKITIDRVAKVASKNKFVKGIIALSGTSKKF-------KNIYDLKELMEDEKFKTQPDFTSPAA 187
            ..:..:.|:.:..:|...|:.||.|    :.|       :|:.|..||.:      .||......
Worm   125 TDEDRLARIRRATAKCPGVRKIICL----RTFPLRTEFPENVLDYVELTQ------TPDQPINVN 179

  Fly   188 NKDEDVSLIVCSSGTTGLPKGVQLTQMNLLATLD-------SQIQPTVIPMEEVT-----LLTVI 240
            ...:.::|:..||||||.|||.|||..|:.|.||       :.:.|.:...|:.|     .:.::
Worm   180 VSMDSIALLPYSSGTTGRPKGCQLTHRNIGAMLDVAKAHLETDVAPAMFGKEKATWHKEHTVLLL 244

  Fly   241 PWFHAFGCLTLITTACVGARLVYLPKFEEKLFLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDL 305
            ||:||:|..|:..|..:|...:...||:..:.|:.|:.|:|.:|::|||:::||||.|:|..::.
Worm   245 PWYHAYGLNTMFETILLGMTGIVFKKFDTIVMLNRIKFYKVKLAWLVPPMLIFLAKDPMVPIFNT 309

  Fly   306 SS-LMVLLCGAAPLSRETEDQIKERIGVPFIRQGYGLSESTLSVLVQ-------NDEFCKPGSVG 362
            :. |.|::...|...::..:::.:|....::.|.||::|     :||       .|..|.. :||
Worm   310 APFLKVIMSAGATAGKQLCEEVSKRFPNAWLCQAYGMTE-----MVQFTTIPRFEDGNCFE-TVG 368

  Fly   363 VLKVGIYAKVIDPDTGKLLGANERGELCFKGDGIMKGYIGDTKSTQTAI--KDGWLHTGDIGYYD 425
            .|......|::|.:..::...|..|:|||:|..:||||:   |..:..|  |||:|.|||:|..|
Worm   369 NLASTYELKILDKEKKEITTINTVGQLCFRGPTVMKGYL---KREEADIIDKDGFLLTGDLGSID 430

  Fly   426 DDFEFFIVDRIKELIKYKGYQVPPAEIEALLLTNDKIKDAAVIGKPDEEAGELPLAFVVKQANVQ 490
            |.....:..|||||||..|.||||.|||.:||.:.|:||.||||.|||..||.|.|::||:.:.
Worm   431 DKGRIHVTGRIKELIKVNGMQVPPVEIEDVLLLHPKVKDCAVIGVPDEHKGESPKAYIVKKDHT- 494

  Fly   491 LTENEVIQFVNDNASPAKRLRGGVIFVDEIPKNPSGKILRRILREMLKKQKS 542
            |||.|:.:||....|..|.: ....|:|.|||.|||||.|:.|::|.:...|
Worm   495 LTEAELTEFVRQKLSSYKWI-DTYEFIDSIPKLPSGKIQRKKLKKMAESSGS 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	169/500 (34%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	166/492 (34%)
acs-6	NP_495450.1	CaiC	15..541	CDD:223395	170/501 (34%)
acs-6	NP_495450.1	Firefly_Luc_like	37..532	CDD:213279	166/492 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I1795
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I1604
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54045
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	1	1.000	-	-		FOG0000951
OrthoInspector	1	1.000	-	-		otm14606
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.980