DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6178 and acs-16

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_490859.1	Gene:	acs-16 / 171714	WormBaseID:	WBGene00018579	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	601	Identity:	147/601 - (24%)
Similarity:	234/601 - (38%)	Gaps:	121/601 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IVYGGPVT-------ERQAQ-DSRSLGQYILDKYKSFGDRTVLVDAVNGVEYSASFMHKSIVRLA 66
            |.|.|.||       .:|.. ||:::.|.|..  ||..||...|.....:..:.|.:...:..||
Worm    11 IDYNGWVTGVSKAPPPKQIDFDSQTIPQLIYT--KSEMDRVAAVFDSEKLSLTFSKIVSEMESLA 73

  Fly    67 YILQKLGVKQNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVTYSDR----------------- 114
            .....:|:||.|.|.::..|.....|...|....|...:..|..|.:.
Worm    74 AGFLSIGLKQGDRVLVAGSNHSQVMLCALACSRAGLVFSLANPNYPNSYSLKRALELGEFQCIVC 138

  Fly   115 ------EVDHAINL---SKPKIIFASKITIDRVAKVASKNKFVKGI--IALSGTSKKFKNIYDLK 168
                  |.||..||   ..|:::        |..|...|::.:..:  :.|:....|....:.|.
Worm   139 FRAHQYEADHLNNLLLEIAPELM--------RSRKGQLKSELLPKLTHVILAEEDHKHAGTFTLS 195

  Fly   169 ELM---EDEKFKTQPDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLTQMNLL----------ATL 220
            |:.   ..||....|||:..:::|   ::.:..:.||||.||.:.|:...:|          ...
Worm   196 EVFLKSSKEKIAKLPDFSKWSSHK---LACLQFTLGTTGAPKLIALSHYQMLNGARAVAAAFGIN 257

  Fly   221 DSQIQPTVIPMEEVTLLTVIPWFHAFGCLTLITTACVGARLVY-----LPKFEEKLFLSAIEKYR 280
            |..:....:|:..:.:..:|       ||:...|.|   |:::     |||   .|| |::.|||
Worm   258 DKHVLACALPIFRIAIFNLI-------CLSPFLTEC---RIIFPDATPLPK---NLF-SSVSKYR 308

  Fly   281 VMMAFMVPPLMVFLAKHPIVDKYDLSSLMVLLCGAAPLSRETEDQIK-ERIGVPFIRQGYGLSES 344
            ..........:..|.|.....:..||:|..:|.....:|:|....|| :...|..|..||.|:|:
Worm   309 CTTLLSNGAALRLLLKISQTQRVKLSALENILLIGDRVSKEVLKLIKVQAENVKIIAVGYLLTET 373

  Fly   345 TLSVLV--QNDEFCKPGSVGVLKVGIYAKVIDPD-------TGKLLGANERGELCFK---GDGIM 397
            ....|:  ||.:|.:  :||....|..|.:|..|       ||||      |:|..:   |...|
Worm   374 GSIPLMGDQNSDFTR--NVGKAIAGYEAHLIPLDGSENQVETGKL------GKLLIRVYYGSTFM 430

  Fly   398 KGYIGDTKSTQTAIKDGWLHTGDIGYYDDDFEFFIVDRIKELIKYK-GYQVPPAEIEALLLTNDK 461
             ||..|||.     |:.|:.|||||..|::....:|....:||..| ...|....:|.||..||.
Worm   431 -GYAPDTKG-----KEKWVDTGDIGRMDENGAIEVVASEDDLIYDKNNCLVEHWNLERLLNQNDL 489

  Fly   462 IKDAAVIGKPDEEAGELPLAFVVKQANVQL----TENEVIQFVNDNASPAKRLRGGVIFVDEIPK 522
            ||...|:.:...:    |:..|....:.|.    .::|:......:...|..:   ..|||:.|:
Worm   490 IKGVQVVSRGRGQ----PVTAVCVARSTQFHAAKLKDELKSMCRSHHFVAPDV---FAFVDDFPR 547

  Fly   523 NPSGKILRRILREMLK 538
            ..: ||.:..:|.||:
Worm   548 VHT-KIQKFRIRAMLE 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	137/574 (24%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	129/549 (23%)
acs-16	NP_490859.1	CaiC	35..565	CDD:223395	139/577 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810