DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p38a and HOG1

DIOPT Version :9

Sequence 1:	NP_001163711.1	Gene:	p38a / 42866	FlyBaseID:	FBgn0015765	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_013214.1	Gene:	HOG1 / 850803	SGDID:	S000004103	Length:	435	Species:	Saccharomyces cerevisiae

Alignment Length:	351	Identity:	177/351 - (50%)
Similarity:	236/351 - (67%)	Gaps:	9/351 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VSITKKFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAK 67
            ::..::|.:..|..|.:||.:.|.||.|||.||:|.|..|....|:..|||||:.:||.:||.||
Yeast     1 MTTNEEFIRTQIFGTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAK 65

  Fly    68 RTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQ 132
            ||||||:||||:.|||:|.|.|||        |...:.:|.||.|...||:.:::.:.|....||
Yeast    66 RTYRELKLLKHLRHENLICLQDIF--------LSPLEDIYFVTELQGTDLHRLLQTRPLEKQFVQ 122

  Fly   133 FLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAPEI 197
            :.:|||||||||:|||||||||||||||.:||:|:|:|.||||||..:.:|||||:||:||||||
Yeast   123 YFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEI 187

  Fly   198 MLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSY 262
            ||.|..||..|||||.|||.||:|..:.||||.||:||.::|.::||:||.:.:..|.||:...:
Yeast   188 MLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKF 252

  Fly   263 IQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQTS-PP 326
            :.|||......|...||...|.|:|||||||..|.:|||||.:||:|||...|.:|:.|..: ..
Yeast   253 VTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPYSAPYHDPTDEPVADAK 317

  Fly   327 YDHSFEDMDLPVDKWKELIYKEVTNF 352
            :|..|.|.|||||.|:.::|.|:.:|
Yeast   318 FDWHFNDADLPVDTWRVMMYSEILDF 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	177/345 (51%)
p38a	NP_001163711.1	S_TKc	25..312	CDD:214567	156/286 (55%)
HOG1	NP_013214.1	STKc_Sty1_Hog1	12..339	CDD:270843	174/334 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I185
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31777
Inparanoid	1	1.050	363	1.000	Inparanoid score	I379
Isobase	1	0.950	-	0	Normalized mean entropy	S378
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	1	1.000	-	-		otm46572
orthoMCL	1	0.900	-	-		OOG6_102675
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X352
TreeFam	0	0.000	Not matched by this tool.
	12	11.810