DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38a and mapk14a

DIOPT Version :9

Sequence 1:	NP_001163711.1	Gene:	p38a / 42866	FlyBaseID:	FBgn0015765	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_571797.1	Gene:	mapk14a / 65237	ZFINID:	ZDB-GENE-010202-2	Length:	361	Species:	Danio rerio

Alignment Length:	355	Identity:	233/355 - (65%)
Similarity:	279/355 - (78%)	Gaps:	3/355 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVSITKKFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVH 65
            ||......||:.::|:|.||:|..||:|.||||||||.|..|....|...||:|||:|||||.:|
Zfish     1 MSQKERPTFYRQEVNKTIWEVPVQYQNLSPVGSGAYGSVCSAFDAKTGFKVAVKKLSRPFQSIIH 65

  Fly    66 AKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDH 130
            ||||||||||||||.|||||||||:|.|..   ||:.|..||||||||.||||||::.|.|:|||
Zfish    66 AKRTYRELRLLKHMRHENVIGLLDVFTPAT---SLKEFNDVYLVTHLMGADLNNIVKCQKLTDDH 127

  Fly   131 VQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAP 195
            ||||:|||||||||||||.:|||||||||:||||||||:||||||||.|::||||||||||||||
Zfish   128 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAP 192

  Fly   196 EIMLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESAR 260
            |||||||||:.||||||||||||||:|.||||||||||:||..||.:.||||:..:.::.|..||
Zfish   193 EIMLNWMHYNVTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPSSLISRMPSHEAR 257

  Fly   261 SYIQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQTSP 325
            :||.|||.|..|:|.:||..|||.|:|||||||.||.:|||||.|||:|||..:|.:|..|..:.
Zfish   258 TYISSLPQMPKRNFADVFIGANPQAVDLLEKMLVLDTDKRITAAEALAHPYFAQYHDPDDEPEAE 322

  Fly   326 PYDHSFEDMDLPVDKWKELIYKEVTNFKPP 355
            |:|.|||..:|.:::||...|:|:.:|:||
Zfish   323 PFDQSFESRELDIEEWKRQTYEEMISFEPP 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	229/344 (67%)
p38a	NP_001163711.1	S_TKc	25..312	CDD:214567	207/286 (72%)
mapk14a	NP_571797.1	STKc_p38alpha	7..351	CDD:143382	229/346 (66%)
		S_TKc	25..309	CDD:214567	207/286 (72%)
		TXY	181..183		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	447	1.000	Domainoid score	I500
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31777
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1274
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	1	1.000	-	-		mtm6418
orthoMCL	1	0.900	-	-		OOG6_102675
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.830