Protein Alignment p38a and MAPK12

DIOPT Version :9

• Sequence 1: NP_001163711.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_002960.2
• Gene: MAPK12 / 6300
• HGNCID: 6874
• Length: 367
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 208/357 - (58%)
• Similarity: 273/357 - (76%)
• Gaps: 4/357 - (1%)

  Fly     9 FYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYREL 73
            ||:.::.:|.||:..:|:|||||||||||.|..||...|...||||||.|||||.:.|||.||||
Human    11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75

  Fly    74 RLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLVYQI 138
            ||||||.|||||||||:|.|   :.:|::|...|||...|..||..:::.:.|.:|.:||||||:
Human    76 RLLKHMRHENVIGLLDVFTP---DETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQM 137

  Fly   139 LRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAPEIMLNWMH 203
            |:||:|||:||:|||||||.|:||||||||:||||||||..::||||||.||||||||::||||.
Human   138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMR 202

  Fly   204 YDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPP 268
            |.||||||||||||||:||.:|||.|:||:.||..||::.|||||||::::.|:.|::|::.||.
Human   203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPE 267

  Fly   269 MKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQTSPPYDHSFED 333
            ::.:.|.::..||:|||::||||||.||||:|:||.|||:|||.|...:...|.....||.||:|
Human   268 LEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDD 332

  Fly   334 MDLPVDKWKELIYKEVTNFKPPPSY-AQVLKD 364
            :|..:|:||.:.||||.:||||... |:|.|:
Human   333 VDRTLDEWKRVTYKEVLSFKPPRQLGARVSKE 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	202/344 (59%)
		S_TKc	25..312	CDD:214567	180/286 (63%)
MAPK12	NP_002960.2	STKc_p38gamma	11..353	CDD:143385	202/344 (59%)
		TXY	183..185		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11342
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.880