Protein Alignment p38a and MAPK10

DIOPT Version :10

• Sequence 1: NP_477163.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_001304998.1
• Gene: MAPK10 / 5602
• HGNCID: 6872
• Length: 478
• Species: Homo sapiens
• Alignment Length: 389
• Identity: 178/389 - (45%)
• Similarity: 252/389 - (64%)
• Gaps: 34/389 - (8%)

  Fly     1 MSVS-ITKKFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAV 64
            ||.| :..:||.:::..:.:.:...||:|:|:||||.|.|..|.....:.:||||||:||||:..
Human    39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQT 103

  Fly    65 HAKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDD 129
            ||||.||||.|:|.::|:|:|.||::|.|..   :||.||.||||..||||:|..:|:|: |..:
Human   104 HAKRAYRELVLMKCVNHKNIISLLNVFTPQK---TLEEFQDVYLVMELMDANLCQVIQME-LDHE 164

  Fly   130 HVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARP--TENEMTGYVATRWY 192
            .:.:|:||:|.|:|::||||:||||||||||.|..||.|:||||||||.  |...||.||.||:|
Human   165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYY 229

  Fly   193 RAPEIMLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSE 257
            ||||::|. |.|.:.||||||||||.|::..:.||||.|:|.|.|.::|.||||..||:||: ..
Human   230 RAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL-QP 292

  Fly   258 SARSYIQSLPPMKGRSFKNVFKNA--------NPL----AIDLLEKMLELDAEKRITAEEALSHP 310
            :.|:|:::.|...|.:|..:|.::        |.|    |.|||.|||.:|..|||:.::||.||
Human   293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357

  Fly   311 YLEKYAEPSVEQTSPP--YDHSFEDMDLPVDKWKELIYKEVTNF-----------KPPPSYAQV 361
            |:..:.:|:..:..||  ||...::.:..:::|||||||||.|.           :|.||.|.|
Human   358 YINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAV 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_477163.1	STKc_p38	9..354	CDD:143356	170/371 (46%)
MAPK10	NP_001304998.1	STKc_JNK	63..398	CDD:270840	165/340 (49%)