Protein Alignment p38a and MAPK9

DIOPT Version :10

• Sequence 1: NP_477163.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_002743.3
• Gene: MAPK9 / 5601
• HGNCID: 6886
• Length: 424
• Species: Homo sapiens
• Alignment Length: 379
• Identity: 177/379 - (46%)
• Similarity: 243/379 - (64%)
• Gaps: 31/379 - (8%)

  Fly     8 KFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRE 72
            :||.:.:..:.:.:...||.|:|:||||.|.|..|......::||:|||:||||:..||||.|||
Human     9 QFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRE 73

  Fly    73 LRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLVYQ 137
            |.|||.::|:|:|.||::|.|..   :||.||.||||..||||:|..:|.|: |..:.:.:|:||
Human    74 LVLLKCVNHKNIISLLNVFTPQK---TLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQ 134

  Fly   138 ILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARP--TENEMTGYVATRWYRAPEIMLN 200
            :|.|:|::||||:||||||||||.|..||.|:||||||||.  |...||.||.||:|||||::|.
Human   135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILG 199

  Fly   201 WMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQS 265
             |.|.:.||||||||||.||:....:|.|||||.|.|.::|.||||.|||:||: ..:.|:|:::
Human   200 -MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKL-QPTVRNYVEN 262

  Fly   266 LPPMKGRSFKNVF------------KNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEP 318
            .|...|..|:.:|            |.....|.|||.|||.:|.:|||:.:|||.|||:..:.:|
Human   263 RPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDP 327

  Fly   319 SVEQTSPP--YDHSFEDMDLPVDKWKELIYKEVTNF---------KPPPSYAQV 361
            :..:..||  ||...|:.:..:::|||||||||.::         |..||.|.|
Human   328 AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAV 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_477163.1	STKc_p38	9..354	CDD:143356	172/369 (47%)
MAPK9	NP_002743.3	STKc_JNK	25..360	CDD:270840	168/340 (49%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..424		5/14 (36%)