Protein Alignment p38a and MAPK8

DIOPT Version :10

• Sequence 1: NP_477163.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_620637.1
• Gene: MAPK8 / 5599
• HGNCID: 6881
• Length: 427
• Species: Homo sapiens
• Alignment Length: 381
• Identity: 177/381 - (46%)
• Similarity: 247/381 - (64%)
• Gaps: 33/381 - (8%)

  Fly     9 FYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYREL 73
            ||.::|..:.:.:...||:|:|:||||.|.|..|.......:||||||:||||:..||||.||||
Human    10 FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL 74

  Fly    74 RLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLVYQI 138
            .|:|.::|:|:||||::|.|..   |||.||.||:|..||||:|..:|:|: |..:.:.:|:||:
Human    75 VLMKCVNHKNIIGLLNVFTPQK---SLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQM 135

  Fly   139 LRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARP--TENEMTGYVATRWYRAPEIMLNW 201
            |.|:|::||||:||||||||||.|..||.|:||||||||.  |...||.||.||:|||||::|.
Human   136 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG- 199

  Fly   202 MHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSL 266
            |.|.:.||:|||||||.|::..:.||||.|:|.|.|.::|.||||..||:||: ..:.|:|:::.
Human   200 MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRTYVENR 263

  Fly   267 PPMKGRSFKNVFKNA--------NPL----AIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPS 319
            |...|.||:.:|.:.        |.|    |.|||.|||.:||.|||:.:|||.|||:..:.:||
Human   264 PKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPS 328

  Fly   320 VEQTSPPY--DHSFEDMDLPVDKWKELIYKEVTNF-----------KPPPSYAQVL 362
            ..:..||.  |...::.:..:::|||||||||.:.           :|.|..|.|:
Human   329 EAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVI 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_477163.1	STKc_p38	9..354	CDD:143356	173/371 (47%)
MAPK8	NP_620637.1	STKc_JNK	25..360	CDD:270840	168/340 (49%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..427		4/14 (29%)