back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p38a and MAPK1

DIOPT Version :9

Sequence 1:	NP_001163711.1	Gene:	p38a / 42866	FlyBaseID:	FBgn0015765	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_002736.3	Gene:	MAPK1 / 5594	HGNCID:	6871	Length:	360	Species:	Homo sapiens

Alignment Length:	337	Identity:	159/337 - (47%)
Similarity:	223/337 - (66%)	Gaps:	12/337 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLD 89
            |.:|..:|.||||.|..|......:.|||||:: ||:...:.:||.||:::|....|||:||:.|
Human    25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGIND 88

  Fly    90 IFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLVYQILRGLKYIHSAGVIHRD 154
            |...    .::|..:.||:|..||:.||..:::.||||:||:.:.:|||||||||||||.|:|||
Human    89 IIRA----PTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRD 149

  Fly   155 LKPSNIAVNEDCELRILDFGLARPTENE------MTGYVATRWYRAPEIMLNWMHYDQTVDIWSV 213
            |||||:.:|..|:|:|.||||||..:.:      :|.|||||||||||||||...|.:::|||||
Human   150 LKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV 214

  Fly   214 GCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVF 278
            |||:||:::.|.:|||..::.|||.|:.:||:|..|.|..|.:..||:|:.|||......:..:|
Human   215 GCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLF 279

  Fly   279 KNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQ-TSPPYDHSFEDMDLPVDKWK 342
            .||:..|:|||:|||..:..|||..|:||:|||||:|.:||.|. ...|:....|..|||.:|.|
Human   280 PNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLK 344

  Fly   343 ELIYKEVTNFKP 354
            |||::|...|:|
Human   345 ELIFEETARFQP 356

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.