DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38a and mapk12b

DIOPT Version :9

Sequence 1:	NP_001163711.1	Gene:	p38a / 42866	FlyBaseID:	FBgn0015765	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001038306.1	Gene:	mapk12b / 557810	ZFINID:	ZDB-GENE-041210-123	Length:	364	Species:	Danio rerio

Alignment Length:	355	Identity:	197/355 - (55%)
Similarity:	258/355 - (72%)	Gaps:	3/355 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVSITKKFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVH 65
            ||:.....||:.:||||.|::|:.|:||..:|:||||.|..|:.|.|.:.||||||.|||||.:.
Zfish     1 MSLRSRAGFYRQEINRTVWDVPERYRDLIQIGTGAYGTVCSAIDRKTGVRVAIKKLHRPFQSRLF 65

  Fly    66 AKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDH 130
            |||.||||||||||.|||||||||:|   .:...|:.|...|||...|..||..:::|:.|.:|.
Zfish    66 AKRAYRELRLLKHMKHENVIGLLDVF---TSEILLDRFHDFYLVMPFMGTDLGKLMKMERLCEDR 127

  Fly   131 VQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAP 195
            |||||||||||||||||||:|||||||.|:|||::|||:||||||||..::||||||.|||||||
Zfish   128 VQFLVYQILRGLKYIHSAGIIHRDLKPGNLAVNQNCELKILDFGLARQADSEMTGYVVTRWYRAP 192

  Fly   196 EIMLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESAR 260
            |::||||||.||||||||||||||::..||||.|.||:.||..||::.|||..:|:.|:.|:.|:
Zfish   193 EVILNWMHYSQTVDIWSVGCIMAEMLLGRTLFKGNDHLDQLREIMKITGTPAPDFITKLQSQDAK 257

  Fly   261 SYIQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQTSP 325
            :||:.||.:..:....:|..|:..|:..||.||.||.:||::|.|||..|...::.||..|..:.
Zfish   258 NYIRGLPKVPKKDLNTIFFKASSEAVSALELMLVLDPDKRVSAAEALELPLFTEFREPEEETEAL 322

  Fly   326 PYDHSFEDMDLPVDKWKELIYKEVTNFKPP 355
            |||||.::.:||:|:||...:.|:.:|:||
Zfish   323 PYDHSMDNTELPLDQWKRHTFTEILSFQPP 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	193/344 (56%)
p38a	NP_001163711.1	S_TKc	25..312	CDD:214567	170/286 (59%)
mapk12b	NP_001038306.1	PKc_like	9..351	CDD:304357	193/344 (56%)
mapk12b	NP_001038306.1	S_TKc	25..307	CDD:214567	169/284 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11339
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.880