Protein Alignment p38a and CILK1

DIOPT Version :10

• Sequence 1: NP_477163.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_001362326.1
• Gene: CILK1 / 22858
• HGNCID: 21219
• Length: 639
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 112/329 - (34%)
• Similarity: 173/329 - (52%)
• Gaps: 45/329 - (13%)

  Fly    25 YQDLQPVGSGAYGQV--SKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGL 87
            |..::.:|.|.||.|  .:::..|.  .:||||:.|.|.|.... ...||::.||.::|.||:.|
Human     4 YTTIRQLGDGTYGSVLLGRSIESGE--LIAIKKMKRKFYSWEEC-MNLREVKSLKKLNHANVVKL 65

  Fly    88 LDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQH--LSDDHVQFLVYQILRGLKYIHSAGV 150
            .::..        || ..:|.:...|..:|..:|:.::  ..:..::.::||||:||.:||..|.
Human    66 KEVIR--------EN-DHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGF 121

  Fly   151 IHRDLKPSNIAVNEDCELRILDFGLARPTENE--MTGYVATRWYRAPEIMLNWMHYDQTVDIWSV 213
            .||||||.|:.......::|.||||||...::  .|.||:||||||||::|...:|...:|:|:|
Human   122 FHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAV 186

  Fly   214 GCIMAELITRRTLFPGTDHIHQLNLIMEMLGTP-----PAEFLKKISSESARSYIQSLPPMKGRS 273
            ||||||:.|.|.||||...|..:..|.::||||     |..:  ::||.....:.|.:|    .:
Human   187 GCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGY--QLSSAMNFRWPQCVP----NN 245

  Fly   274 FKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYL----------------EKYAEPSVEQ 322
            .|.:..||:..|:.||..||:.|.:||.||.:||.:||.                ||..:..:|:
Human   246 LKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDSEKPQKGILEK 310

  Fly   323 TSPP 326
            ..||
Human   311 AGPP 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_477163.1	STKc_p38	9..354	CDD:143356	112/329 (34%)
CILK1	NP_001362326.1	STKc_MAK_like	4..284	CDD:270824	106/297 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..344		5/25 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..488
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	589..639