DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38a and pmk-1

DIOPT Version :9

Sequence 1:	NP_001163711.1	Gene:	p38a / 42866	FlyBaseID:	FBgn0015765	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_501365.1	Gene:	pmk-1 / 191743	WormBaseID:	WBGene00004055	Length:	377	Species:	Caenorhabditis elegans

Alignment Length:	363	Identity:	214/363 - (58%)
Similarity:	275/363 - (75%)	Gaps:	17/363 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYREL 73
            :|.:::||:.|.:|:.|.:|.|:|:||||.|..|....:...|||||..|||||.:||:||||||
Worm    19 YYVVELNRSVWVVPNYYINLTPIGTGAYGTVCAAECTRSGTRVAIKKFNRPFQSIIHARRTYREL 83

  Fly    74 RLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLVYQI 138
            |||:.|.|||:|.|||:|.|   |.::.:.:.||.|:.||.|||:||:::|.|:|||:|||||||
Worm    84 RLLRCMCHENIIDLLDVFTP---NENVNDIEDVYFVSMLMGADLSNILKIQRLNDDHIQFLVYQI 145

  Fly   139 LRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAPEIMLNWMH 203
            ||||||||||.:||||||||||||||||||:||||||||.|::||||||||||||||||||||||
Worm   146 LRGLKYIHSADIIHRDLKPSNIAVNEDCELKILDFGLARQTDSEMTGYVATRWYRAPEIMLNWMH 210

  Fly   204 YDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPP 268
            |.||||:||||||:|||||.:|||||:|||.||..||.:.|||..|||||||||.||:||::||.
Worm   211 YTQTVDVWSVGCILAELITGKTLFPGSDHIDQLTRIMSVTGTPDEEFLKKISSEEARNYIRNLPK 275

  Fly   269 MKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQTSPPYDHSFED 333
            |..|.||.:|..|.|.|||||||||.||.::|.||:||:.|.||..|.:.:.|..:       |:
Worm   276 MTRRDFKRLFAQATPQAIDLLEKMLHLDPDRRPTAKEAMEHEYLAAYHDETDEPIA-------EE 333

  Fly   334 MDL-------PVDKWKELIYKEVTNFKPPPSYAQVLKD 364
            |||       .:|:||::|::|:::|:...::|...:|
Worm   334 MDLNDDVRADTIDEWKKIIWEEISDFQKNVAFADEEED 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	212/351 (60%)
p38a	NP_001163711.1	S_TKc	25..312	CDD:214567	193/286 (67%)
pmk-1	NP_501365.1	STKc_p38	19..361	CDD:143356	212/351 (60%)
pmk-1	NP_501365.1	S_TKc	35..319	CDD:214567	193/286 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157467
Domainoid	1	1.000	404	1.000	Domainoid score	I365
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31777
Inparanoid	1	1.050	453	1.000	Inparanoid score	I897
Isobase	1	0.950	-	0	Normalized mean entropy	S378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	1	1.000	-	-		otm14777
orthoMCL	1	0.900	-	-		OOG6_102675
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.710