Protein Alignment p38a and Nlk

DIOPT Version :10

• Sequence 1: NP_477163.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_032728.3
• Gene: Nlk / 18099
• MGIID: 1201387
• Length: 527
• Species: Mus musculus
• Alignment Length: 371
• Identity: 150/371 - (40%)
• Similarity: 210/371 - (56%)
• Gaps: 56/371 - (15%)

  Fly    11 KLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRL 75
            :|||.      ||     :|:|.||:|.|...........||:||:...||:.|..||.:|||::
Mouse   135 QLDIE------PD-----RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKM 188

  Fly    76 LKHMDHENVIGLLDIFH-PHPANGSLENFQQVYLVTHLMDADLNNII-RMQHLSDDHVQFLVYQI 138
            |....|:||:..|||.. ||     ::.|:::|:||.||.:||:.|| ..|.||.|||:..:|||
Mouse   189 LCFFKHDNVLSALDILQPPH-----IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQI 248

  Fly   139 LRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTE----NEMTGYVATRWYRAPEIML 199
            ||||||:||||::|||:||.|:.||.:|.|:|.||||||..|    ..||..|.|::||||||::
Mouse   249 LRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILM 313

  Fly   200 NWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYI- 263
            ...||...:||||||||.|||:.||.||.....|.||:||.::||||..|.: :.:.|.|:::|
Mouse   314 GSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAM-RTACEGAKAHIL 377

  Fly   264 ------QSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEK-------- 314
                  .|||.:...|     ..|...|:.||.:||..|..|||:|::||:||||::
Mouse   378 RGPHKQPSLPVLYTLS-----SQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTC 437

  Fly   315 -------------YAEPSVEQTSPPYDHSFEDMDLPVDKWKELIYK 347
                         |.......|:|.:|.:||.....|.:.||:|::
Mouse   438 MCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQ 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_477163.1	STKc_p38	9..354	CDD:143356	150/371 (40%)
Nlk	NP_032728.3	Required for interaction with TAB2. /evidence=ECO:0000269|PubMed:20194509	1..304		82/184 (45%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000250|UniProtKB:Q9UBE8	1..125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..72
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..139		2/3 (67%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000250|UniProtKB:Q9UBE8	124..416		131/302 (43%)
		STKc_NLK	137..508	CDD:173748	149/369 (40%)
		TQE. /evidence=ECO:0000269|PubMed:15082531, ECO:0000269|PubMed:21118996, ECO:0000269|PubMed:9448268	298..300		1/1 (100%)
		Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000269|PubMed:21118996	428..527		10/56 (18%)
		Required for interaction with TAB2. /evidence=ECO:0000269|PubMed:20194509	434..527		10/50 (20%)