Protein Alignment p38a and mpk-2

DIOPT Version :10

• Sequence 1: NP_477163.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_494946.2
• Gene: mpk-2 / 173880
• WormBaseID: WBGene00003402
• Length: 605
• Species: Caenorhabditis elegans
• Alignment Length: 354
• Identity: 144/354 - (40%)
• Similarity: 206/354 - (58%)
• Gaps: 31/354 - (8%)

  Fly    31 VGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDIFHPHP 95
            ||:||||.|.||:.......|||||:.|.|.:...|||:.||:|:|:.:.|||:|.:||:|....
 Worm    63 VGAGAYGVVCKAMDTRNKKQVAIKKIPRAFTAHTLAKRSLREVRILRELLHENIIAVLDMFTAEG 127

  Fly    96 ANGSLENFQQVYLVTHLMDADLNNIIR-MQHLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSN 159
            |:|     :.:|||..||:.||:.|:. .|.|.:.|.|:..||:||||||:||||:|||||||||
 Worm   128 AHG-----KDIYLVMDLMETDLHQILHSRQTLMEQHFQYFFYQLLRGLKYLHSAGIIHRDLKPSN 187

  Fly   160 IAVNEDCELRILDFGLARP------------TENEMTGYVATRWYRAPEIMLNWMHYDQTVDIWS 212
            :.:|.||.|||.|||:||.            ....||.||:|||||||||:.:.:.||..||:||
 Worm   188 LLLNGDCLLRIADFGMARAYASASTVRDDANVGGHMTQYVSTRWYRAPEILFSMVEYDTKVDLWS 252

  Fly   213 VGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNV 277
            .|||.||::.||.||||.|.:.|:.:|:..||:|..|.:.:|:|:..|..|::........|..:
 Worm   253 AGCIFAEMLLRRQLFPGKDSVSQIKMIVYYLGSPEEEVINRITSDLVRDSIEACGRKTPLPFSAI 317

  Fly   278 FKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQTSPP-----YD--HSFEDMD 335
            |..|:|.|.:::..:|::...||.:|::.|.||::.:|.....|...||     .|  ..||...
 Worm   318 FPKASPEARNMVSYLLQISPWKRYSADQILQHPFMAQYHNDQYEPLCPPRVQVDVDAIERFEGAQ 382

  Fly   336 LPVDKWKELIYKEV---TNF---KPPPSY 358
            :.....:|....|:   ||:   |.||.|
 Worm   383 VVAGLDEEARIFEMRRGTNYDTRKTPPPY 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_477163.1	STKc_p38	9..354	CDD:143356	140/348 (40%)
mpk-2	NP_494946.2	Protein Kinases, catalytic domain	54..376	CDD:473864	134/317 (42%)