Protein Alignment p38a and CSNK2A1

DIOPT Version :10

• Sequence 1: NP_477163.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_001886.1
• Gene: CSNK2A1 / 1457
• HGNCID: 2457
• Length: 391
• Species: Homo sapiens
• Alignment Length: 317
• Identity: 97/317 - (30%)
• Similarity: 177/317 - (55%)
• Gaps: 26/317 - (8%)

  Fly     7 KKFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYR 71
            ::::..:.:..||...|.||.::.:|.|.|.:|.:| :..||....:.|:.:|    |..|:..|
Human    21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-INITNNEKVVVKILKP----VKKKKIKR 80

  Fly    72 ELRLLKHM-DHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLV 135
            |:::|::: ...|:|.|.||.....:......|:      |:.:.|...:  .|.|:|..::|.:
Human    81 EIKILENLRGGPNIITLADIVKDPVSRTPALVFE------HVNNTDFKQL--YQTLTDYDIRFYM 137

  Fly   136 YQILRGLKYIHSAGVIHRDLKPSNIAV-NEDCELRILDFGLA---RPTENEMTGYVATRWYRAPE 196
            |:||:.|.|.||.|::|||:||.|:.: :|..:||::|:|||   .|.: |....||:|:::.||
Human   138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPE 201

  Fly   197 IMLNWMHYDQTVDIWSVGCIMAELITRR-TLFPGTDHIHQLNLIMEMLGTPPA-EFLKKISSESA 259
            :::::..||.::|:||:||::|.:|.|: ..|.|.|:..||..|.::|||... :::.|.:.|..
Human   202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266

  Fly   260 RSYIQSLPPMKGRSFKNVFKNAN-----PLAIDLLEKMLELDAEKRITAEEALSHPY 311
            ..:...|.....:.::....:.|     |.|:|.|:|:|..|.:.|:||.||:.|||
Human   267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_477163.1	STKc_p38	9..354	CDD:143356	97/315 (31%)
CSNK2A1	NP_001886.1	STKc_CK2_alpha	20..325	CDD:271034	97/317 (31%)
		Interaction with beta subunit. /evidence=ECO:0000250	36..41		2/4 (50%)