DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38a and Mapk7

DIOPT Version :9

Sequence 1:	NP_001163711.1	Gene:	p38a / 42866	FlyBaseID:	FBgn0015765	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001178476.1	Gene:	Mapk7 / 114509	RGDID:	621505	Length:	812	Species:	Rattus norvegicus

Alignment Length:	343	Identity:	163/343 - (47%)
Similarity:	230/343 - (67%)	Gaps:	12/343 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 WEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHEN 83
            :::.|.|:.::.:|:||||.||.|..|.|...|||||:...|....:||||.|||::|||..|:|
  Rat    49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 113

  Fly    84 VIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIR-MQHLSDDHVQFLVYQILRGLKYIHS 147
            :|.:.||..|....|   .|:.||:|..||::||:.||. .|.|:.:||::.:||:||||||:||
  Rat   114 IIAIKDILRPTVPYG---EFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHS 175

  Fly   148 AGVIHRDLKPSNIAVNEDCELRILDFGLAR-----PTENE--MTGYVATRWYRAPEIMLNWMHYD 205
            |.||||||||||:.|||:|||:|.|||:||     |.|::  ||.|||||||||||:||:...|.
  Rat   176 AQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT 240

  Fly   206 QTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMK 270
            |.:|:||||||..|::.||.||||.:::|||.|||.:||||....::.:.:|..|:|||||||.:
  Rat   241 QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQ 305

  Fly   271 GRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVE-QTSPPYDHSFEDM 334
            ...::.|:..|:..|:.||.:||..:...||:|..||.||:|.||.:|..| ..:||:|.:|:..
  Rat   306 PVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDRE 370

  Fly   335 DLPVDKWKELIYKEVTNF 352
            .|..::.||.|..|:.:|
  Rat   371 ALTRERIKEAIVAEIEDF 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	163/343 (48%)
p38a	NP_001163711.1	S_TKc	25..312	CDD:214567	147/294 (50%)
Mapk7	NP_001178476.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for cytoplasmic targeting. /evidence=ECO:0000250	2..77		11/27 (41%)
		STKc_ERK5	49..384	CDD:270842	161/337 (48%)
		Required for binding to MAP2K5. /evidence=ECO:0000250	78..139		27/63 (43%)
		Necessary for oligomerization. /evidence=ECO:0000250	140..406		123/249 (49%)
		TXY. /evidence=ECO:0000250	219..221		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..475
		Nuclear localization signal. /evidence=ECO:0000250	505..539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810