Protein Alignment p38a and CDK7

DIOPT Version :10

• Sequence 1: NP_477163.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_001790.1
• Gene: CDK7 / 1022
• HGNCID: 1778
• Length: 346
• Species: Homo sapiens
• Alignment Length: 353
• Identity: 119/353 - (33%)
• Similarity: 175/353 - (49%)
• Gaps: 49/353 - (13%)

  Fly    25 YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAK----RT-YRELRLLKHMDHENV 84
            |:.|..:|.|.:..|.||..:.||..|||||:....:|  .||    || .||::||:.:.|.|:
Human    12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRS--EAKDGINRTALREIKLLQELSHPNI 74

  Fly    85 IGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQH--LSDDHVQFLVYQILRGLKYIHS 147
            |||||.| .|.:|        :.||...|:.||..||:...  |:..|::..:...|:||:|:|.
Human    75 IGLLDAF-GHKSN--------ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130

  Fly   148 AGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGY---VATRWYRAPEIMLNWMHYDQTVD 209
            ..::||||||:|:.::|:..|::.|||||:...:....|   |.||||||||::.....|...||
Human   131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVD 195

  Fly   210 IWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSF 274
            :|:||||:|||:.|....||...:.||..|.|.||||..|....:.|.......:|.|   |...
Human   196 MWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFP---GIPL 257

  Fly   275 KNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPS---------------VEQTS 324
            .::|..|....:||::.:...:...||||.:||...|......|:               .||::
Human   258 HHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSN 322

  Fly   325 PPY------DHSFEDMDLPVDKWKELIY 346
            |..      ..:.|...||    |:||:
Human   323 PALAIKRKRTEALEQGGLP----KKLIF 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_477163.1	STKc_p38	9..354	CDD:143356	119/353 (34%)
CDK7	NP_001790.1	STKc_CDK7	11..308	CDD:270833	110/309 (36%)