DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38a and mapk13

DIOPT Version :9

Sequence 1:	NP_001163711.1	Gene:	p38a / 42866	FlyBaseID:	FBgn0015765	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	XP_031751532.1	Gene:	mapk13 / 100144715	XenbaseID:	XB-GENE-490713	Length:	377	Species:	Xenopus tropicalis

Alignment Length:	356	Identity:	205/356 - (57%)
Similarity:	258/356 - (72%)	Gaps:	6/356 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVSITKKFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVH 65
            ||.|:..||.|.::|:|.||||..|..|..|||||||.|..|:...|...||||||:|||||.:.
Frog     1 MSSSVKCKFRKEEVNKTLWEIPLRYASLCLVGSGAYGSVCSAIDLKTGEKVAIKKLSRPFQSEIF 65

  Fly    66 AKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDH 130
            |||.:|||.|||||:|||||||||:|   .:..|..:|...|||...|..||..|:. .|||:|.
Frog    66 AKRAFRELTLLKHMNHENVIGLLDVF---TSATSFNDFHNFYLVMPYMQIDLQKIMG-HHLSEDK 126

  Fly   131 VQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAP 195
            ||:||||:|.||||||:||:|||||||.|:||||||||:||||||||..:.||||||.|||||||
Frog   127 VQYLVYQMLCGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAP 191

  Fly   196 EIMLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESAR 260
            |::||||||::|||||||||||.|::|.:|||.|.|::.||..|:::.|.|..||::|:...:|:
Frog   192 EVILNWMHYNKTVDIWSVGCIMGEMLTGKTLFKGKDYLDQLTQILKVTGVPGPEFIQKLEDMAAK 256

  Fly   261 SYIQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQTSP 325
            .||||||.:..:.|..:|.||:.||:||||||||||.|||:||.|||.|||.:::.:...|..:|
Frog   257 KYIQSLPKIPKKEFSLLFPNASDLAVDLLEKMLELDVEKRLTATEALEHPYFDEFHDADEETEAP 321

  Fly   326 PYDHSFEDMDLPVDKW--KELIYKEVTNFKP 354
            |||.|.|...|.|::|  ||..|:||.|:.|
Frog   322 PYDDSLEGEKLSVEEWRSKEYTYEEVINYTP 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	200/346 (58%)
p38a	NP_001163711.1	S_TKc	25..312	CDD:214567	175/286 (61%)
mapk13	XP_031751532.1	STKc_p38delta	9..352	CDD:143384	200/346 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020