DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38a and mapk13

DIOPT Version :9

Sequence 1:	NP_001163711.1	Gene:	p38a / 42866	FlyBaseID:	FBgn0015765	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	XP_001337833.2	Gene:	mapk13 / 100002318	ZFINID:	ZDB-GENE-041111-17	Length:	362	Species:	Danio rerio

Alignment Length:	349	Identity:	192/349 - (55%)
Similarity:	247/349 - (70%)	Gaps:	5/349 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRE 72
            :|.:.:||.|.||:|..|..|:.:|:||||.|..::...|...||||||.|||||.:.|||.|||
Zfish     6 EFSREEINSTVWEVPAKYVCLKQIGTGAYGSVCSSINNKTKEKVAIKKLHRPFQSEIFAKRAYRE 70

  Fly    73 LRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLVYQ 137
            |||||||.|||||||||:|.|..   .|:.||..|||...|..||:.:..:  |::|.:||||||
Zfish    71 LRLLKHMKHENVIGLLDVFTPAT---RLDEFQDFYLVMPYMYTDLSKVKGL--LTEDRIQFLVYQ 130

  Fly   138 ILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAPEIMLNWM 202
            :|.||||||.||:|||||||.|:|||:||||:||||||||.|:.||||||.||||||||::||||
Zfish   131 MLCGLKYIHGAGIIHRDLKPGNLAVNQDCELKILDFGLARHTDAEMTGYVVTRWYRAPEVILNWM 195

  Fly   203 HYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLP 267
            ||.||||||||||||.|:...:|||.|.|::.||..||::.|||..||::|:.|..|:||::|||
Zfish   196 HYTQTVDIWSVGCIMGEMFNGKTLFKGKDYMDQLTQIMKVAGTPGPEFVEKLESPEAKSYVRSLP 260

  Fly   268 PMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQTSPPYDHSFE 332
            ....|.|..:|..|:..|::||||||.|||:.|:||..||:|.|.:...:|........||.|::
Zfish   261 HYPHRDFSTLFPRASKKAVELLEKMLVLDADARLTASGALAHSYFDGLRDPDDWPEPTAYDDSYD 325

  Fly   333 DMDLPVDKWKELIYKEVTNFKPPP 356
            :..||:::||.|.:|||.:|.|.|
Zfish   326 NATLPLEEWKRLSFKEVRSFVPFP 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	190/344 (55%)
p38a	NP_001163711.1	S_TKc	25..312	CDD:214567	169/286 (59%)
mapk13	XP_001337833.2	PKc_like	7..347	CDD:304357	190/344 (55%)
mapk13	XP_001337833.2	S_TKc	23..305	CDD:214567	169/286 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.880