Protein Alignment Kal1 and ANOS1

DIOPT Version :9

• Sequence 1: NP_651220.3
• Gene: Kal1 / 42865
• FlyBaseID: FBgn0039155
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_000207.2
• Gene: ANOS1 / 3730
• HGNCID: 6211
• Length: 680
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 157/645 - (24%)
• Similarity: 253/645 - (39%)
• Gaps: 170/645 - (26%)

  Fly     2 GSMQVA-----LLALLV--LGQLFPSAVANGSSSYSSTSTSASNQLQRQKLAHWFRDSNDVKDKI 59
            ||:|.|     .|:|.:  :...|.....|||..:      ..|..|..|.....::|.|::
Human    42 GSVQRARCASRCLSLQITRISAFFQHFQNNGSLVW------CQNHKQCSKCLEPCKESGDLR--- 97

  Fly    60 LELQCLAKCGSNPTTKAGREQCLNKC--IQELLLGPRAGSCPKIGRQSRARLSCLDNCQYDHECP 122
             :.||.:.|  .|.......:||..|  ::.:|| .:.|.||...:.|....:|:::|:.|:||.
Human    98 -KHQCQSFC--EPLFPKKSYECLTSCEFLKYILL-VKQGDCPAPEKASGFAAACVESCEVDNECS 158

  Fly   123 EVQKCCPSSCGPMCVEPLGVRNNTQLPPIPKILYFRRSRGHAVDLKIES----SLLVYYFHVEVR 183
            .|:|||.:.||..|..|..:.....|.| .|.|.|...:...:::|..|    |:....:.|:.|
Human   159 GVKKCCSNGCGHTCQVPKTLYKGVPLKP-RKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRR 222

  Fly   184 SHIGRHFAARKLGPWQ-----WQKVEKTMEENIGHSKHTYIFFHMRPGRWYEVRVAAVNAYGFRG 243
            .:.|.|       |.:     ||.|.:|.:|.:.       ...:||.|||:.||||||.:|.||
Human   223 WNYGIH-------PSEDDATHWQTVAQTTDERVQ-------LTDIRPSRWYQFRVAAVNVHGTRG 273

  Fly   244 YSEPSDPFPSTGNPKPPKSPNDSKIIGK--QFDGRYMTLKLVW-CPSKSNLPVEKYKITWSLYVN 305
            ::.||..|.|:.:|..|.:|.:.::...  ..||. :|:.:|| .|.:.::||..||:.||..|
Human   274 FTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGS-VTVTIVWDLPEEPDIPVHHYKVFWSWMV- 336

  Fly   306 SAKASMITNSSYVKDTHQFE----IKELLPNSSYYIQVQAISYLGSRRLKSEQWSMLFNTT---- 362
            |:|:.:.|.....|.|..|:    :::|.|:..|.:::|||:|.|..||||.:.|:.|.:|
Human   337 SSKSLVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATN 401

  Fly   363 ------------------------LQPLEPITPLQCSG--------------NGNRRR------- 382
                                    .:|||...|....|              ..||..
Human   402 NKEQLVKTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEA 466

  Fly   383 --HHHTSSSMSSERATTSEPVALNEVS------PTI-----TNRTSAAATY-------------- 420
              |:.|:.|.:|...|....:.|.::|      .|:     .:.:.|.|.:
Human   467 CAHNRTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKSH 531

  Fly   421 -------EVGFRL--------NRKFGMIVQILGFQPH------KEKVYELCP----QETNCE-QR 459
                   |.|..|        |.....|||.:....|      |..:|:  |    |.|..| ..
Human   532 KPVGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKANLYQ--PMTGFQVTWAEVTT 594

  Fly   460 EFRAIRAKKDPLEFSKLKYNTTYVLRIPRSSPNSVL-----------DDSRNVFTFTTPK 508
            |.|........:..|::..:..|||.:|...|:::.           :....:.||.||:
Human   595 ESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPE 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kal1	NP_651220.3	WAP	96..139	CDD:278522	16/42 (38%)
		fn3	<177..245	CDD:278470	24/72 (33%)
		fn3	279..343	CDD:278470	22/68 (32%)
ANOS1	NP_000207.2	WAP	130..176	CDD:197580	16/45 (36%)
		fn3	186..275	CDD:278470	31/103 (30%)
		FN3	290..381	CDD:238020	28/92 (30%)
		fn3	550..646	CDD:278470	19/97 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..680		4/13 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160143
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4802
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D415772at33208
OrthoFinder	1	1.000	-	-		FOG0007219
OrthoInspector	1	1.000	-	-		oto88608
orthoMCL	1	0.900	-	-		OOG6_107197
Panther	1	1.100	-	-	LDO	PTHR14131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3210
SonicParanoid	1	1.000	-	-		X6094
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.740