DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kal1 and anos1

DIOPT Version :9

Sequence 1:	NP_651220.3	Gene:	Kal1 / 42865	FlyBaseID:	FBgn0039155	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001107160.1	Gene:	anos1 / 100135017	XenbaseID:	XB-GENE-488217	Length:	683	Species:	Xenopus tropicalis

Alignment Length:	525	Identity:	129/525 - (24%)
Similarity:	222/525 - (42%)	Gaps:	86/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NGSSSYSSTSTSASNQLQRQKLAHWFRDSNDVKDKILELQCLAKCGSNPTTKAGREQCLNKC-IQ 87
            |||..:.......|..|:..|.....|.:|          |...|  .|.......:||..| ..
Frog    76 NGSLIWCQNHKQCSKCLEPCKETWDLRKNN----------CHNLC--EPLFPKKHYECLTSCEFL 128

  Fly    88 ELLLGPRAGSCPKIGRQSRARLSCLDNCQYDHECPEVQKCCPSSCGPMCVEPLGVRNNTQLPPIP 152
            :.:|..:.|.||...:.|....:|:::|..|:||..|:|||.:.||..|..|..:.....|.|..
Frog   129 KSVLSVKQGDCPAPEKASGFAAACVESCDADNECSGVKKCCSNGCGHTCQVPKNLYKGVPLKPRK 193

  Fly   153 KILYFRRSRGHAVDLKIESSL------LVYYFHVEVRSHIGRHFAARKLGPWQWQKVEKTMEENI 211
            ::.:.....|| :|:|..|..      ::|.  |:.|.:.|.|.:.....  .||.:.:..:|.:
Frog   194 ELTFDEPQPGH-LDIKWSSKFNISVEPVIYV--VQRRWNYGIHPSEDDAS--NWQTMAQITDERV 253

  Fly   212 GHSKHTYIFFHMRPGRWYEVRVAAVNAYGFRGYSEPSDPFPSTGNPKPPKSPNDSKI--IGKQFD 274
            ..|       .:||.|||:.||||||.:|.||::.||..|.|:.:|.||.:|.:.:|  :....:
Frog   254 QLS-------DIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSPPPAPTNLRISNLTTNNE 311

  Fly   275 GRYMTLKLVW-CPSKSNLPVEKYKITWSLYVNSAKASMITNSSYVKDT-----HQFEIKELLPNS 333
            |. :::::.| .|.:.::||..||:.||...|  :.|::......:.|     :...:..|..||
Frog   312 GT-VSVRITWDLPEEPDIPVHHYKVFWSWTAN--RKSVVPAKKKRRKTTEGSQNSVALDGLQANS 373

  Fly   334 SYYIQVQAISYLGSRRLKSEQWSMLFNTTLQPLEPITPLQCSGNGNRRRHHHTSSSMSSERATTS 398
            :|.:::|||:|.|..||||.:.|:.|:|                        :..|.|.::.:..
Frog   374 NYMVELQAITYWGQVRLKSGKVSLYFST------------------------SPPSTSLDQISKI 414

  Fly   399 EPVALNEVSPTITNRTSAAATYEVGFRLNRKFGMIVQI---------LGFQPHKEKVYELCP-QE 453
            ..:..:.::|....||  |...|:|....:...:.|::         ||.. |.:...|.|. .|
Frog   415 SKMKTDILAPPQRKRT--ARMLEIGAPFYQDNQLQVKVYWKKTEDSMLGLY-HVQWFPESCAHNE 476

  Fly   454 TNCEQREFRAIRAKKDPLEFSKLKYNTTYVLRIPRSSPNSVLDDSRNVFTFTTPKCENFRKRFPK 518
            |...::..    .:...:....|.::..|.:.:..:.|...| .:.::| ||||.|...:.:..|
Frog   477 TKGPEKAV----TQDHHIVLPALLFSCKYKVTVHPARPKDHL-KAESIF-FTTPPCSTLKGKTHK 535

  Fly   519 LQIKC 523
             ||.|
Frog   536 -QINC 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kal1	NP_651220.3	WAP	96..139	CDD:278522	16/42 (38%)
		fn3	<177..245	CDD:278470	22/67 (33%)
		fn3	279..343	CDD:278470	17/69 (25%)
anos1	NP_001107160.1	Cys_box	49..130	CDD:375393	14/65 (22%)
		WAP	135..181	CDD:197580	16/45 (36%)
		fn3	191..279	CDD:365830	28/99 (28%)
		FN3	295..386	CDD:238020	23/93 (25%)
		fn3	553..647	CDD:365830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D415772at33208
OrthoFinder	1	1.000	-	-		FOG0007219
OrthoInspector	1	1.000	-	-		oto102483
Panther	1	1.100	-	-	LDO	PTHR14131
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6094
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.020