DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec10 and RCY1

DIOPT Version :9

Sequence 1:	NP_651218.1	Gene:	Sec10 / 42863	FlyBaseID:	FBgn0266673	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_012331.1	Gene:	RCY1 / 853226	SGDID:	S000003740	Length:	840	Species:	Saccharomyces cerevisiae

Alignment Length:	820	Identity:	166/820 - (20%)
Similarity:	313/820 - (38%)	Gaps:	204/820 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 ILQEKQQSKCERLE---ESLRQEKESHAKKIAKLQER-HQTAIDVF-------GQLDEKI----- 103
            |:..|..||...|:   ..|:|...:..::|..|.|. :|.::.:|       .|..:||
Yeast    36 IINGKNDSKYWSLKLTRMGLQQVHSNEEEEITLLDENDNQNSLRIFEIYKSFTAQNSKKIFVKFY 100

  Fly   104 ---NSVAGKIMHLGEQLENVNTPRSRS---VEAQKLLNFMSEF-------------LAAGPVIVN 149
               ||.|.|:.:  ..|.|. .|.|.|   ::..::|||:.::             :.....|:.
Yeast   101 RCYNSYARKLYN--NNLANF-FPTSYSNDPLKQTRILNFIKKYNFSNKNDIETFTRIETNFNILR 162

  Fly   150 DIF-----------------ADAARL-------SEAADVIQKLYAISQDLPPG----------NF 180
            :||                 |..||.       :|.::.|: .:....||||.          .:
Yeast   163 EIFINSVLKESELNYQSNNLAAVARFMKILLISNEESNAIE-FFKSKADLPPSLTVLPSNDELFW 226

  Fly   181 AESKRKIEKKYDEV--ERRLIEEFATAQKSEDIERMKTLAQIL--SQFKGYTQCVDAYIEQ---- 237
            ||..|:.:.....|  ..:.::.|....:....|::| ||.||  .:|....|.::::|:.
Yeast   227 AEQPREEDSGGSTVIFNSKNLDTFLNQLRDFLNEKIK-LADILFKDEFPVILQFIESFIQDILLD 290

  Fly   238 ---------SQMQPYSGKDIFIGIVPLCKHHYEIIQKVF------------------ANPQQVMS 275
                     |:....:|||        .|.:||.:.:::                  ||.::|:
Yeast   291 ILNNILLSYSEFLKENGKD--------SKANYECVPELYFTFIKKFDTELNDSVNAGANFRKVV- 346

  Fly   276 KFILNIY--------------------QLKLHQYAMTKLEDKKDEEKYLRTLYELYSRTLKLSTD 320
            :.:||:|                    ..:|..|. |:::||:.|:.     .::|: |||..||
Yeast   347 RDLLNLYLEPFVVNYMNQTTRVFESLINSQLANYD-TQVQDKQREQN-----AKIYN-TLKDQTD 404

  Fly   321 LQIYMSTIDDDLLQKLTQQIFIKHLAGYAEMETKCLTAKCSTELEKFYASKKHQKTATTKGFR-- 383
            ..   |..:::|...|:  |..:......|.::|..|...|.........|....::.||.|:
Yeast   405 AS---SASNNELPNDLS--IITETSKTVPEADSKPSTIHQSVHSTDISNDKLDFLSSFTKIFKFS 464

  Fly   384 ----RNMEVLIATRANINIAAIEDYGGETFLSEELAINMLQEAKASLKRC-RLLSNETELPGNAI 443
                :.::..:....|:|:.:......::.:|.:|...:|||......:. :..:.|:.||  .|
Yeast   465 NNENQRLKQQLQLAYNLNLISNNLQNIKSLISLDLCYKILQETSEKTDQIYKFHTIESLLP--LI 527

  Fly   444 KLN-----DILLRFLMHEHVDYA------------------LELGLQAVPLAEGRVFPQLYFFDV 485
            ||.     .||:..|...||..|                  :|:...::..|..:|.|.:.|.::
Yeast   528 KLRCQEIFKILITQLNKNHVKPAFEKAILLLQKYNPNEIEQIEIKFNSLSPANTQVEPLVQFTEL 592

  Fly   486 VQKTNIIVHLLDKLCHTSVIPCVSNTPKYSDYVFKKRILMEQIETKLD----QGLDRSISAVIGW 546
            :...:||:.::.......:|| .....|..|::.....|.:..||.:|    :||:..|:.::..
Yeast   593 INIGDIILQMISIFYKNELIP-KKIIDKNKDFLNDVIQLKKNFETSIDDFVAEGLNIGINKLMDE 656

  Fly   547 VKVYLQYEQKKTDYKP-----ETDVDTISSAAC-LQVVQNLQPVIVQIKKCVDGENLQNVLTEFG 605
            :....:..|...||.|     .:.:..|....| ::||:.|......:....|...:.....|.|
Yeast   657 ISFVFKTLQLPDDYNPPPPSRNSPIRDIKPTKCAIRVVELLSNHCFLLTGATDKGTIDVYQQEIG 721

  Fly   606 TRLHRVIYDHLQTMQFNTAGAMCAICDVNEYRKCI-RELDSPLVTQLFDILHALCNLLLVKPQNL 669
            .|....|..||:....:|.||:..|||:|.:...| .:|....|...|..|.::..|.::..::.
Yeast   722 ERFFNEIVKHLKKCFISTEGAIWLICDLNYFYDFIANKLKQKNVVPYFVGLKSIGQLYIISGKDS 786

  Fly   670 QEVCTGDTLNYLDK-------SVVRQFIQLRTDF-RIIKN 701
            :|:  |..::.|.|       ..:.:|:|.|:|: |:.|:
Yeast   787 KEL--GKLISDLGKFNGIFTQEEIYEFVQRRSDWVRVRKD 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec10	NP_651218.1	RILP-like	46..>103	CDD:304877	13/58 (22%)
Sec10	NP_651218.1	Sec10	89..705	CDD:284746	156/782 (20%)
RCY1	NP_012331.1	Sec10	101..827	CDD:399988	151/755 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344848
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3745
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12100
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2282
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960