DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec10 and sec10

DIOPT Version :9

Sequence 1:	NP_651218.1	Gene:	Sec10 / 42863	FlyBaseID:	FBgn0266673	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_593654.1	Gene:	sec10 / 2542843	PomBaseID:	SPAC13F5.06c	Length:	811	Species:	Schizosaccharomyces pombe

Alignment Length:	812	Identity:	156/812 - (19%)
Similarity:	296/812 - (36%)	Gaps:	183/812 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EFIERLT---WRTNNELQNSEDFHPV-ALHDTFIQTIKDLKILQEKQQSKCERLEESLRQEKESH 78
            ||:|:..   :.|.|:  .|:....: ....:|...:.:|..|:.:...:......:.:|.:..:
pombe    28 EFVEKFAESLYETQND--GSKKLSSIDGSIKSFAACLHELNRLKSRVGDRIRDYASASKQVQNEY 90

  Fly    79 AKKIAKLQERHQTAIDVFGQLDEKINSVAGKIMHLGEQLENVNTPRSRSVEAQKLLNFMSEFLAA 143
            .:|...|:|:....:::...|::.:|.:...::..|::||.....|.|.:.:.:||.:..||.:.
pombe    91 HQKSNHLREKFAQVLELSRHLEDNVNDMRSGLVDAGQELERAENNRKRILSSAELLRYYLEFRSG 155

  Fly   144 GPVIVNDIFA--DAARLSEAADVIQKLYAISQDLPPGNFAESKRKIEKKYDEVERRLIEEFATAQ 206
            .|..:.|.|.  :..::...|...::|.|::.::...:.:|:..:|||..:.:|...::.|....
pombe   156 KPQTLMDFFRTNNHDKMLLCAQRTRQLLALANEVDLPDSSETLARIEKFSEFLETNFLKFFNNEY 220

  Fly   207 KSEDIERMKTLAQILSQFKGYTQCVDAYIEQ-------SQMQPYSG------------------- 245
            :..:.:.|.:...||.:|.|....|..::.|       .::|...|
pombe   221 RKPNWKGMASFGTILQEFNGGASVVREFVNQHEFFIAADKVQSRQGLEQDPIWLILPDPTQKIPP 285

  Fly   246 -----KDIFIGIVPLCKHHYEIIQKVFANPQQVMSKFILNIYQLKLHQYAMTKLEDKKDEEK--- 302
                 ..:|..:..:.:....:|::||.||:.|:..|...|:    .|....:||:..:..|
pombe   286 LIQTLSSLFSELCSVIEGDCAVIKRVFPNPELVLQTFFQRIF----GQSIQNRLEEVMEIAKGKS 346

  Fly   303 ---YLRTLYELYSRTLKLSTDLQIYMS----TIDDDLLQKLTQQIFIKHLA-------GYAEMET 353
               |||||..:.|...||..||:..:.    ::.|:....|....:::.|.       .|.:.|.
pombe   347 NLAYLRTLQTVVSSLRKLVADLKTILENRGFSVSDNSPLSLALNQYMEDLLVPFIEVDDYLKREE 411

  Fly   354 KCLTAKCSTELEKFYASKKHQKTATTKGFRR--------NMEVLIATRANINIAAIEDYGGETFL 410
            ..|.:.....|.| |.|.|.:......|..|        ||.......:..|...      |.||
pombe   412 HSLRSLFRLSLYK-YTSYKIRLETPEPGLLRSLMTPLQGNMVAPTGVHSQFNTKT------EGFL 469

  Fly   411 SEELAINMLQEAKASLKRCRLLSNETELPGNAIKLNDILLRFLMHEHVD----YALELGLQAVPL 471
               |.|..:||        .|:.:.:.:..:.|.:..      .|.|::    |:. :|..|..|
pombe   470 ---LRIADIQE--------NLIQSGSFITEDYITIEK------NHSHLNSEKVYSF-IGWHAEAL 516

  Fly   472 AEGRVFPQLYFFDVVQKTNIIVHLLDKLCHTSVIPCVSNTPKYSDYVFKKRILMEQIETKLD--Q 534
            ....:........||  .:.:|:|||||..             .|||||:...::...:..|  :
pombe   517 NRASILISSQDLSVV--ISSLVNLLDKLIR-------------EDYVFKELSSIQSYISSHDKSK 566

  Fly   535 GLD-------RSISAVIGWVKVYLQ-----YEQKKTDYKPETDVDTISSAACLQVVQ-------- 579
            .||       |....::|:...||.     :.......:.|| |:.:||:  :.|::
pombe   567 NLDLHYLVDIRECKKIMGYFSAYLMSIVIPFTGVTASSRRET-VNILSSS--ISVIECAVNDVFY 628

  Fly   580 --------NLQPVIV---QIKKCVDGE--------------NLQNVLTEFGTRLHRV-IYD---- 614
                    :|:.::.   ||...:..|              |:||.|.......||: .||
pombe   629 ATVHALGDHLEIILSPYRQISYAMTEEQIDSSTELRQSMTRNVQNYLDYIKNLYHRLGPYDPSLL 693

  Fly   615 ----HLQTM------------QFNTAGAMCAICDVNEYRKCIRELDSPLVTQLFDILHALCNLLL 663
                ...||            :...|||:....|:|.:...:.......|...|.::..|.:||:
pombe   694 ALKQKTATMLAAMLISFAFRSKVTAAGALLLQNDINFFHSTLTSWGIDTVDAKFKLILQLLSLLM 758

  Fly   664 VKPQNLQEVCTGDTLNYLDKSVVRQFIQLRTD 695
            ||...|..|..........:..:.:.::||.|
pombe   759 VKIDVLPAVMQDKRKAGFSEMNIHEVLRLRFD 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec10	NP_651218.1	RILP-like	46..>103	CDD:304877	8/56 (14%)
Sec10	NP_651218.1	Sec10	89..705	CDD:284746	143/737 (19%)
sec10	NP_593654.1	Sec10	101..799	CDD:284746	143/737 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3745
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38195
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54308
OrthoFinder	1	1.000	-	-		FOG0004379
OrthoInspector	1	1.000	-	-		oto100759
orthoMCL	1	0.900	-	-		OOG6_102983
Panther	1	1.100	-	-	LDO	PTHR12100
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2282
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.850