DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec10 and pof6

DIOPT Version :9

Sequence 1:	NP_651218.1	Gene:	Sec10 / 42863	FlyBaseID:	FBgn0266673	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_588383.1	Gene:	pof6 / 2539324	PomBaseID:	SPCC18.04	Length:	872	Species:	Schizosaccharomyces pombe

Alignment Length:	885	Identity:	161/885 - (18%)
Similarity:	311/885 - (35%)	Gaps:	227/885 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LSQYMEEFEQEPFE-------VGEFIERLTWRTNNELQNSE----------DFHPVALHDTFIQT 49
            :.:|:|...::.|:       :..:::..|..:..:|.|..          |::.:.:....:..
pombe    14 IKEYLERRHKQQFKALFGCLTINIYLKIFTLISTPDLCNCRLVCRKFQQLCDYNSIYVKKLLLMN 78

  Fly    50 IKDLKI---LQEKQQSKCERLEESLRQEK----ESHAKKIAKLQERHQTAIDVFGQLDEKI---- 103
            ..|:.:   |..:.|....:...|....|    :|..||.|.......::..:....|:||
pombe    79 AWDVTLSRKLYYESQDGMSQANMSSNTSKGFHLQSSDKKYADSDRPKLSSSSLLSLPDQKIPFPV 143

  Fly   104 --NSVAGKIMHLGEQLENVNTPRSRSVEAQKLLNFMSEFLAAGPVIVNDIFA----DAARLS--- 159
              ::|.||.:.| ..|:.|    |:.||..: |:::..:.|..|:..|..:|    |....|
pombe   144 DYSTVQGKQVVL-TVLDCV----SQRVEFAR-LDYIKVWRALAPIYRNLAYASNTIDPIAFSAFR 202

  Fly   160 ---EAADVIQKLYAISQDLPPGNFAES-KRKIEKKYDEVERRLIEEFATAQKSEDIERMKTLAQI 220
               |.:.|::.|.......|.|.:.:: :..|.......|:..::||.....|.:::.::..:.:
pombe   203 TPEEQSKVLKYLIRFGNSYPYGTYRQAMQNAILDMASLFEQACLDEFELGLHSRNLDLLRKFSHV 267

  Fly   221 LSQFKGYTQCVDAYIEQS--------QMQPYS--------------------------------- 244
            |..|.|....|..|:.:.        ...|||
pombe   268 LHDFSGPNAYVSMYLAKQTDFVRSFFHFDPYSLFISNNLEEIHINWNILESVVNDTIKLLESESK 332

  Fly   245 ----------------GKDIFIG------IVPLCKH---------------HYEIIQKVFANP-- 270
                            .||| :|      ::.:|:|               .|.:.:|.|:.|
pombe   333 FSEATLPEPELVQVPYAKDI-LGNSLKDYVISICEHIGEEETELFLVFISGFYGLCKKFFSIPNG 396

  Fly   271 --------QQVMSKFILNIYQLKLHQYAMT----------KLEDKKDEEKYL-------RTLYEL 310
                    |..:..||    ..:||.:...          |||:|:|..:..       .|....
pombe   397 PALVDTIFQPQIDIFI----SQELHYFKTVGWSLVDQWDQKLEEKEDATECFFYKNVSQNTAKNN 457

  Fly   311 YSRTLKLSTDLQIYMSTIDDD------LLQKLTQQIFIKHLAGYAEMETKCLTAKCSTELEK--- 366
            :..|.|....|.:.:.||..:      |.:|..:|         .|.|        ..||.|
pombe   458 FLETFKNVMLLPVSLFTIPSENNSASNLAEKAIEQ---------KEEE--------DPELSKLDA 505

  Fly   367 -------FYASK---KHQKTATTKGFRRNMEVLIATRANINIAAIEDYGGETFLSEELAINMLQE 421
                   .|.||   ||..|..           :|.:|.:..:.:|  |..|..|.|||:.::..
pombe   506 ARFVPANIYVSKDRLKHLPTTE-----------LAAQAAVLDSKLE--GISTMFSLELALKIVHL 557

  Fly   422 AKASLKRCRL-----LSNETELPGNAIKLNDILLRFLMHEHVDYALELGLQAVPLAEGR------ 475
            .|.||.|.::     :..:.::.|.:..|...|||.|...|:.:..:..::.:...:.|
pombe   558 CKVSLARAKVFMGTSVPQDDDIKGLSKDLFVQLLRELGQGHLKHGFDRAIEHLSSFDPRRDFSSN 622

  Fly   476 -VFPQLYFFDVVQKTNIIVHLLDKLCHTSVIPCVSNTPKYSDYVFKKRILMEQIETKLDQGLDRS 539
             |.|.:.|.:::...::|..::|...:..:.|.......:...:.:|:...:.::.:...||.:.
pombe   623 TVEPVVKFLELINVGDMIQQMMDSFFNEEMSPICVKDDMFDPAIAEKKKFEQLLDERAAFGLHKG 687

  Fly   540 ISAVIGWVKVYLQYEQKKTDYKPET---DVDTIS-SAACLQVVQNLQPVIVQIKKCVDGENLQNV 600
            |:.:|......|:.:.....:..:|   ..:||. :||...|||.|...:..:....|.|.|...
pombe   688 INVLIEHADFLLETKTPMNLFSDQTIGSITNTIEPTAAAKNVVQFLGFHMRILVGRADHEILDVF 752

  Fly   601 LTEFGTRLHRVIYDHLQTMQFNTAGAMCAICDVNEYRKCIRELDSPLVTQLFDILHALCNLLLVK 665
            ..|.|.||...:..::::.:|:..|.:..:.|.|.|.:.|..|....:...|..|..:.:|.::.
pombe   753 YKEVGMRLFDSLTRYIKSHKFSVDGGLKLLSDCNLYYEFIHSLHQSSLLPYFKTLKEIAHLFIID 817

  Fly   666 PQNLQEV--CTGDTLNY---LDKSVVRQFIQLRTDFRIIK 700
            .:|.:|:  ...||..:   .....|.:.:..|.|:..||
pombe   818 GKNAEEIGKLATDTSRFSSAFHTEEVYEILHSRIDWLNIK 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec10	NP_651218.1	RILP-like	46..>103	CDD:304877	10/63 (16%)
Sec10	NP_651218.1	Sec10	89..705	CDD:284746	145/774 (19%)
pof6	NP_588383.1	FBOX	33..73	CDD:197608	4/39 (10%)
pof6	NP_588383.1	Sec10	179..862	CDD:284746	131/714 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3745
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12100
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2282
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030