Protein Alignment Sec10 and pof6

DIOPT Version :10

• Sequence 1: NP_651218.1
• Gene: Sec10 / 42863
• FlyBaseID: FBgn0266673
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_588383.1
• Gene: pof6 / 2539324
• PomBaseID: SPCC18.04
• Length: 872
• Species: Schizosaccharomyces pombe
• Alignment Length: 885
• Identity: 161/885 - (18%)
• Similarity: 311/885 - (35%)
• Gaps: 227/885 - (25%)

  Fly     2 LSQYMEEFEQEPFE-------VGEFIERLTWRTNNELQNSE----------DFHPVALHDTFIQT 49
            :.:|:|...::.|:       :..:::..|..:..:|.|..          |::.:.:....:..
pombe    14 IKEYLERRHKQQFKALFGCLTINIYLKIFTLISTPDLCNCRLVCRKFQQLCDYNSIYVKKLLLMN 78

  Fly    50 IKDLKI---LQEKQQSKCERLEESLRQEK----ESHAKKIAKLQERHQTAIDVFGQLDEKI---- 103
            ..|:.:   |..:.|....:...|....|    :|..||.|.......::..:....|:||
pombe    79 AWDVTLSRKLYYESQDGMSQANMSSNTSKGFHLQSSDKKYADSDRPKLSSSSLLSLPDQKIPFPV 143

  Fly   104 --NSVAGKIMHLGEQLENVNTPRSRSVEAQKLLNFMSEFLAAGPVIVNDIFA----DAARLS--- 159
              ::|.||.:.| ..|:.|    |:.||..: |:::..:.|..|:..|..:|    |....|
pombe   144 DYSTVQGKQVVL-TVLDCV----SQRVEFAR-LDYIKVWRALAPIYRNLAYASNTIDPIAFSAFR 202

  Fly   160 ---EAADVIQKLYAISQDLPPGNFAES-KRKIEKKYDEVERRLIEEFATAQKSEDIERMKTLAQI 220
               |.:.|::.|.......|.|.:.:: :..|.......|:..::||.....|.:::.::..:.:
pombe   203 TPEEQSKVLKYLIRFGNSYPYGTYRQAMQNAILDMASLFEQACLDEFELGLHSRNLDLLRKFSHV 267

  Fly   221 LSQFKGYTQCVDAYIEQS--------QMQPYS--------------------------------- 244
            |..|.|....|..|:.:.        ...|||
pombe   268 LHDFSGPNAYVSMYLAKQTDFVRSFFHFDPYSLFISNNLEEIHINWNILESVVNDTIKLLESESK 332

  Fly   245 ----------------GKDIFIG------IVPLCKH---------------HYEIIQKVFANP-- 270
                            .||| :|      ::.:|:|               .|.:.:|.|:.|
pombe   333 FSEATLPEPELVQVPYAKDI-LGNSLKDYVISICEHIGEEETELFLVFISGFYGLCKKFFSIPNG 396

  Fly   271 --------QQVMSKFILNIYQLKLHQYAMT----------KLEDKKDEEKYL-------RTLYEL 310
                    |..:..||    ..:||.:...          |||:|:|..:..       .|....
pombe   397 PALVDTIFQPQIDIFI----SQELHYFKTVGWSLVDQWDQKLEEKEDATECFFYKNVSQNTAKNN 457

  Fly   311 YSRTLKLSTDLQIYMSTIDDD------LLQKLTQQIFIKHLAGYAEMETKCLTAKCSTELEK--- 366
            :..|.|....|.:.:.||..:      |.:|..:|         .|.|        ..||.|
pombe   458 FLETFKNVMLLPVSLFTIPSENNSASNLAEKAIEQ---------KEEE--------DPELSKLDA 505

  Fly   367 -------FYASK---KHQKTATTKGFRRNMEVLIATRANINIAAIEDYGGETFLSEELAINMLQE 421
                   .|.||   ||..|..           :|.:|.:..:.:|  |..|..|.|||:.::..
pombe   506 ARFVPANIYVSKDRLKHLPTTE-----------LAAQAAVLDSKLE--GISTMFSLELALKIVHL 557

  Fly   422 AKASLKRCRL-----LSNETELPGNAIKLNDILLRFLMHEHVDYALELGLQAVPLAEGR------ 475
            .|.||.|.::     :..:.::.|.:..|...|||.|...|:.:..:..::.:...:.|
pombe   558 CKVSLARAKVFMGTSVPQDDDIKGLSKDLFVQLLRELGQGHLKHGFDRAIEHLSSFDPRRDFSSN 622

  Fly   476 -VFPQLYFFDVVQKTNIIVHLLDKLCHTSVIPCVSNTPKYSDYVFKKRILMEQIETKLDQGLDRS 539
             |.|.:.|.:::...::|..::|...:..:.|.......:...:.:|:...:.::.:...||.:.
pombe   623 TVEPVVKFLELINVGDMIQQMMDSFFNEEMSPICVKDDMFDPAIAEKKKFEQLLDERAAFGLHKG 687

  Fly   540 ISAVIGWVKVYLQYEQKKTDYKPET---DVDTIS-SAACLQVVQNLQPVIVQIKKCVDGENLQNV 600
            |:.:|......|:.:.....:..:|   ..:||. :||...|||.|...:..:....|.|.|...
pombe   688 INVLIEHADFLLETKTPMNLFSDQTIGSITNTIEPTAAAKNVVQFLGFHMRILVGRADHEILDVF 752

  Fly   601 LTEFGTRLHRVIYDHLQTMQFNTAGAMCAICDVNEYRKCIRELDSPLVTQLFDILHALCNLLLVK 665
            ..|.|.||...:..::::.:|:..|.:..:.|.|.|.:.|..|....:...|..|..:.:|.::.
pombe   753 YKEVGMRLFDSLTRYIKSHKFSVDGGLKLLSDCNLYYEFIHSLHQSSLLPYFKTLKEIAHLFIID 817

  Fly   666 PQNLQEV--CTGDTLNY---LDKSVVRQFIQLRTDFRIIK 700
            .:|.:|:  ...||..:   .....|.:.:..|.|:..||
pombe   818 GKNAEEIGKLATDTSRFSSAFHTEEVYEILHSRIDWLNIK 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec10	NP_651218.1	Sec10	89..705	CDD:399988	145/774 (19%)
pof6	NP_588383.1	F-box_unchar	30..74	CDD:438911	4/43 (9%)
		Sec10	202..862	CDD:399988	126/691 (18%)