Protein Alignment Sec10 and Exoc5

DIOPT Version :9

• Sequence 1: NP_651218.1
• Gene: Sec10 / 42863
• FlyBaseID: FBgn0266673
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: XP_011243185.1
• Gene: Exoc5 / 105504
• MGIID: 2145645
• Length: 723
• Species: Mus musculus
• Alignment Length: 712
• Identity: 299/712 - (41%)
• Similarity: 456/712 - (64%)
• Gaps: 25/712 - (3%)

  Fly     8 EFEQEPFEVGEFIERLTWRT--NNELQNSEDFHPVALHDTFIQTIKDLKILQEKQQSKCERLEES 70
            |..:|||...|:||||.|||  .......|.|.|..|.:.|:..|::|:|:.|:.|.|.|:||:.
Mouse     6 ELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQ 70

  Fly    71 LRQEKESHAKKIAKLQERHQTAIDVFGQLDEKINSVAGKIMHLGEQLENVNTPRSRSVEAQKLLN 135
            .::|.:..|||:.:||:.:|.|...|.:|||.|:.||.|:.|||:|||.|||||.|:||||||:.
Mouse    71 CQKEAKEFAKKVQELQKSNQVAFQHFQELDEHISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMK 135

  Fly   136 FMSEFLAAGPVIVNDIFADAARLSEAADVIQKLYAISQDLPPGNFAESKRKIEKKYDEVERRLIE 200
            :.:|||..  .:.:|:|.::.::.|||||||||:.|:|:||...|:|.|.||..||.::|.:||:
Mouse   136 YFNEFLDG--ELKSDVFTNSEKIKEAADVIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQ 198

  Fly   201 EFATAQKSEDIERMKTLAQILSQFKGYTQCVDAYIEQSQMQPYSGKDIFIGIVPLCKHHYEIIQK 265
            ||.:||:..::.||:.:|.:|..||||:.|:|.||:|.|...|...|||.....||:...:.:..
Mouse   199 EFTSAQRRGEVSRMREVAAVLLHFKGYSHCIDVYIKQCQEGAYLRNDIFEDAAILCQRVNKQVGD 263

  Fly   266 VFANPQQVMSKFILNIYQLKLHQYAMTKLED--KKDEEKYLRTLYELYSRTLKLSTDL-QIYMST 327
            :|:||:.|::|.|.:::::||..:...:||:  |.|.|:||::||:||:||..||:.| :..:.|
Mouse   264 IFSNPEAVLAKLIQSVFEIKLQSFVKDQLEECRKSDAEQYLKSLYDLYTRTTGLSSKLMEFNLGT 328

  Fly   328 IDDDLLQKLTQQIFIKHLAGYAEMETKCLTAKCSTELEKFYASKKHQKTATTKGFRRNMEVLIAT 392
            .....|.||.:.|||.:|..|.|:|...|.::.:..|:::|.||.|||.:...|..::::..|..
Mouse   329 DKQTFLSKLIKSIFISYLENYIEVEIGYLKSRSAMILQRYYDSKNHQKRSIGTGGIQDLKERIRQ 393

  Fly   393 RANINIAAIEDYGGETFLSEELAINMLQEAKASLKRCRLLSNETELPGNAIKLNDILLRFLMHEH 457
            |.|:.:....|..||||||:|:.:|:|||.|.:.:||..||:.::||.||.::..||:.||..||
Mouse   394 RTNLPLGPSIDTHGETFLSQEVVVNLLQETKQAFERCHRLSDPSDLPRNAFRIFTILVEFLCIEH 458

  Fly   458 VDYALELGLQ---------------AVPLAEGRVFPQLYFFDVVQKTNIIVHLLDKLCHTSVIPC 507
            :|||||.||.               .:|.::.| ...|||.||||:.|.|.||.||..:..::|.
Mouse   459 IDYALETGLAVFLKVVPTYLCLPILGIPSSDSR-NANLYFLDVVQQANTIFHLFDKQFNDHLMPL 522

  Fly   508 VSNTPKYSDYVFKKRILMEQIETKLDQGLDRSISAVIGWVKVYLQYEQKKTDYKPETDVDTI--S 570
            :|::||.|:.:.||:.::||:|.|||.|:||:::.:||.:|..|..||||||:|||.:.:.:  .
Mouse   523 ISSSPKLSECLQKKKEIIEQMEMKLDTGIDRTLNCMIGQMKHILAAEQKKTDFKPEDENNVLIQY 587

  Fly   571 SAACLQVVQNLQPVIVQIKKCVDGENLQNVLTEFGTRLHRVIYDHLQTMQFNTAGAMCAICDVNE 635
            :.||::|...::..:.:||..:||:|:..||.|.|.|.||:||:|||...::..|.|.|||||.|
Mouse   588 TNACVKVCVYVRKQVEKIKNSMDGKNVDTVLMELGVRFHRLIYEHLQQYSYSCMGGMLAICDVAE 652

  Fly   636 YRKCIRELDSPLVTQLFDILHALCNLLLVKPQNLQEVCTGDTLNYLDKSVVRQFIQLRTDFR 697
            ||||.::...|:|..|||.||||||||:|.|.||::||:|:.|..|||:::..|:|||.|:|
Mouse   653 YRKCAKDFKIPMVLHLFDTLHALCNLLVVAPDNLKQVCSGEQLANLDKNILHSFVQLRADYR 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec10	NP_651218.1	RILP-like	46..>103	CDD:304877	22/56 (39%)
		Sec10	89..705	CDD:284746	267/629 (42%)
Exoc5	XP_011243185.1	Tmemb_cc2	<25..>84	CDD:370936	19/58 (33%)
		Sec10	89..714	CDD:369345	266/627 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842689
Domainoid	1	1.000	521	1.000	Domainoid score	I304
eggNOG	1	0.900	-	-		E1_KOG3745
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38195
Inparanoid	1	1.050	579	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54308
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004379
OrthoInspector	1	1.000	-	-		oto92539
orthoMCL	1	0.900	-	-		OOG6_102983
Panther	1	1.100	-	-	LDO	PTHR12100
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2282
SonicParanoid	1	1.000	-	-		X5499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790