DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tsc1 and TSC1

DIOPT Version :9

Sequence 1:NP_477415.1 Gene:Tsc1 / 42862 FlyBaseID:FBgn0026317 Length:1100 Species:Drosophila melanogaster
Sequence 2:NP_000359.1 Gene:TSC1 / 7248 HGNCID:12362 Length:1164 Species:Homo sapiens


Alignment Length:1258 Identity:291/1258 - (23%)
Similarity:504/1258 - (40%) Gaps:270/1258 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IEKIIGDLESNMTLENEEAKRKLVELLSQNKEQWVVKFMLDYFFTTGSQRILEVLVKAQAPHDGY 67
            :.:::..|:|.|....::......|.|:.::...:|..::||:..|.||..|.:|...|.|||.:
Human     7 VGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHILTTLQEPHDKH 71

  Fly    68 IFDKLDDCLKQSQHRVQSLQVFCFIVRHHPTWLYKIEKHRLIKSVFKLMTHEKEIVPLMSALLCI 132
            :.|::::.:.::..|:..|.:...::|..|:|.:|:.:..|:.|:.|.:..:.::|.|.:.:|.:
Human    72 LLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVL 136

  Fly   133 ITLLPIIPNSVPNFLNDLFEVFGHLASWKLQNSNKLPDEKLVHLQLGLQMLFHRLYGMYPCSFIA 197
            ||:||:||.|....|.|.|::||.|:||.|:....:.:..||||...:..|||||||||||:|::
Human   137 ITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHLHASVYALFHRLYGMYPCNFVS 201

  Fly   198 YLVEFIKRGNGGGIFQHTIKPLLNTVRVHPMLVTATPETEVNNTRWKEMEPHDVVMECANLSL-P 261
            :|............|:..:||::..||:||.|||.:.:.|::..|||.:|.||||:|||.:|| |
Human   202 FLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKRLETHDVVIECAKISLDP 266

  Fly   262 VLLPETSNEDG-SYAYPMTPGYSRMTSNTSNTDYSYQLREFQQSRNVYTRFDSFASGDDVGPIWS 325
            .   |.|.||| |.::.::..:...:::.:.:.|:       .::|.|        |......:|
Human   267 T---EASYEDGYSVSHQISARFPHRSADVTTSPYA-------DTQNSY--------GCATSTPYS 313

  Fly   326 PHNEIATTSSG-IPLT---PTTSFIL-PLQPAMNSQLMV-GMTGSSPPEAAVEATPETTPLKDMR 384
            ....:.....| :|.|   |:|..|. |.|..:.|..|| |||           ||.|:|.....
Human   314 TSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMT-----------TPPTSPGNVPP 367

  Fly   385 DIKQPGRAVNSHAVRAIF--------------AVSQPSSPM-RKDQQSQFSFPDVS------REA 428
            |:        ||....:|              |.|.|.:|: ..|.....|.|..:      .|.
Human   368 DL--------SHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPRKEER 424

  Fly   429 EESSHSYLEVNRGTAYDRRLSQVIQDRHNVE--RSVNTPCPSSLPEINSDLSLVGGSVYPSVTQE 491
            .:|:...|         .|...::.||.:.|  .|..:...|.||....||:....|:  ...:|
Human   425 MDSARPCL---------HRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSI--EKDKE 478

  Fly   492 VAAVCGECNETD----RNLCSVGGLHMPTSRSMHQLAKKRRNRMASYSGNGSCADSRSSAAKKAS 552
            .||:..|.:|..    ..:...||...|..|.             |..|:.....|.:|:::.||
Human   479 EAAISRELSEITTAEAEPVVPRGGFDSPFYRD-------------SLPGSQRKTHSAASSSQGAS 530

  Fly   553 WSTEAENPMRRTKSCSALSGMRQQHLEENDDEAD--CSSQRQRGENGNTQKTGSRLQRSGRNLAI 615
            .:.|   |:.     |:|..:.....::.....|  |.|       .:....|.|..::....:|
Human   531 VNPE---PLH-----SSLDKLGPDTPKQAFTPIDLPCGS-------ADESPAGDRECQTSLETSI 580

  Fly   616 SAPKDTARSCTHASTQTVEGLDSA-PAQYE------------NWLI----ELLLECKEQRIDYER 663
            ..|     |.......|..|..|. |..|:            :::|    |||.:.|....:...
Human   581 FTP-----SPCKIPPPTRVGFGSGQPPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGV 640

  Fly   664 NLLYPQDILDEYIKHAIKA-----------NESFD--------------AEQGQLMCL--QLEYE 701
            ....|.::||..|:....|           ::|.|              ..:.||:.|  ||.||
Human   641 PSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYE 705

  Fly   702 SYRRSIHAERNRRLMGRSRDKRSLEMERDRLREQLKNFDAKNKDLANKMDQAIRLANERQNIHQE 766
            .::|..||.|||||:.:.....:||.....:::|||   .:.||:     |..:::.:::.....
Human   706 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK---LQEKDI-----QMWKVSLQKEQARYN 762

  Fly   767 ELGEMR-----------AKYQHELEEKKCLRQANDDLQTRLTSELARHKEMNYELESLRGQVFSL 820
            :|.|.|           .:.||:.||   ....:.:|||:|........|:..||:....:|...
Human   763 QLQEQRDTMVTKLHSQIRQLQHDREE---FYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 824

  Fly   821 GTELQHTQQQADIGLQCKQELARLEAEFIIMGEVQVRCRDRLAEIDNFRARDEELQMLQESSNLE 885
            ...|....|:.......:|::..|..:.:::|||.....::|.  :......:|::|::.:...|
Human   825 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQ--NKHSDTTKEVEMMKAAYRKE 887

  Fly   886 LKDLRHSLDEKTSQLESMKHKISDLQAQLANSEKAMTEQKRLLSTVKDEYEEKFKSVNKKYDVQK 950
            |:..|..:.::|.:|::.:.:|.:|::.||..:..:.|||:.|..||.:...:.::...:|:.||
Human   888 LEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQK 952

  Fly   951 KIIMQMEEKLM---------------------------------------MMMQQPQGTTGHN-- 974
            :|....|.:::                                       .|:...:..:|||  
Human   953 RITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGE 1017

  Fly   975 TCSPDTDRTDIASSIERNSPLSTSLASSESLSASLRSTELKNLHQLVD-------------TPTI 1026
            |.:|       ..|..|.|..|.....|.|.|:.| ||..|..||...             :.:|
Human  1018 TKTP-------RPSSARGSSGSRGGGGSSSSSSEL-STPEKPPHQRAGPFSSRWETTMGEASASI 1074

  Fly  1027 PDVLNSMAGGAQF-----------EDEVRPPAVDLASSASTASAINIVPHALDLPSTSGGIGHTL 1080
            |..:.|:.....|           :.|.:.....:.||.|.:....:   ..|| .....|...|
Human  1075 PTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTEL---GKDL-GVEAKIPLNL 1135

  Fly  1081 THPHPHP-------HLHLQQQQQ 1096
            ..|||.|       .||:....:
Human  1136 DGPHPSPPTPDSVGQLHIMDYNE 1158

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tsc1NP_477415.1 Hamartin 3..715 CDD:282270 199/792 (25%)
KASH_CCD 736..915 CDD:291334 37/189 (20%)
TSC1NP_000359.1 Hamartin 7..719 CDD:398199 199/792 (25%)
Mediates interaction with WDR45B. /evidence=ECO:0000269|PubMed:28561066 403..787 89/435 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 439..571 33/161 (20%)
Smc <751..>971 CDD:224117 45/224 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1006..1085 21/86 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1131..1164 8/28 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151752
Domainoid 1 1.000 67 1.000 Domainoid score I9864
eggNOG 1 0.900 - - E1_2CAZQ
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 277 1.000 Inparanoid score I2955
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47070
OrthoDB 1 1.010 - - D131264at2759
OrthoFinder 1 1.000 - - FOG0004719
OrthoInspector 1 1.000 - - oto89526
orthoMCL 1 0.900 - - OOG6_108503
Panther 1 1.100 - - LDO PTHR15154
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5359
SonicParanoid 1 1.000 - - X4416
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.890

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