Protein Alignment Tsc1 and TSC1

DIOPT Version :10

• Sequence 1: NP_477415.1
• Gene: Tsc1 / 42862
• FlyBaseID: FBgn0026317
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: NP_000359.1
• Gene: TSC1 / 7248
• HGNCID: 12362
• Length: 1164
• Species: Homo sapiens
• Alignment Length: 1262
• Identity: 291/1262 - (23%)
• Similarity: 504/1262 - (39%)
• Gaps: 278/1262 - (22%)

  Fly     3 IEKIIGDLESNMTLENEEAKRKLVELLSQNKEQWVVKFMLDYFFTTGSQRILEVLVKAQAPHDGY 67
            :.:::..|:|.|....::......|.|:.::...:|..::||:..|.||..|.:|...|.|||.:
Human     7 VGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHILTTLQEPHDKH 71

  Fly    68 IFDKLDDCLKQSQHRVQSLQVFCFIVRHHPTWLYKIEKHRLIKSVFKLMTHEKEIVPLMSALLCI 132
            :.|::::.:.::..|:..|.:...::|..|:|.:|:.:..|:.|:.|.:..:.::|.|.:.:|.:
Human    72 LLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVL 136

  Fly   133 ITLLPIIPNSVPNFLNDLFEVFGHLASWKLQNSNKLPDEKLVHLQLGLQMLFHRLYGMYPCSFIA 197
            ||:||:||.|....|.|.|::||.|:||.|:....:.:..||||...:..|||||||||||:|::
Human   137 ITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHLHASVYALFHRLYGMYPCNFVS 201

  Fly   198 YLVEFIKRGNGGGIFQHTIKPLLNTVRVHPMLVTATPETEVNNTRWKEMEPHDVVMECANLSL-P 261
            :|............|:..:||::..||:||.|||.:.:.|::..|||.:|.||||:|||.:|| |
Human   202 FLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKRLETHDVVIECAKISLDP 266

  Fly   262 VLLPETSNEDG-SYAYPMTPGYSRMTSNTSNTDYSYQLREFQQSRNVYTRFDSFASGDDVGPIWS 325
            .   |.|.||| |.::.::..:...:::.:.:.|:       .::|.|        |......:|
Human   267 T---EASYEDGYSVSHQISARFPHRSADVTTSPYA-------DTQNSY--------GCATSTPYS 313

  Fly   326 PHNEIATTSSG-IPLT---PTTSFIL-PLQPAMNSQLMV-GMT------GSSPPE---------- 368
            ....:.....| :|.|   |:|..|. |.|..:.|..|| |||      |:.||:
Human   314 TSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPTSPGNVPPDLSHPYSKVFG 378

  Fly   369 --AAVEATPETTPLKDMRDIKQPGRAVNSHAVRAIFAVSQPSSPM-RKDQQSQFSFPDVS----- 425
              |..:.||..||                       |.|.|.:|: ..|.....|.|..:
Human   379 TTAGGKGTPLGTP-----------------------ATSPPPAPLCHSDDYVHISLPQATVTPPR 420

  Fly   426 -REAEESSHSYLEVNRGTAYDRRLSQVIQDRHNVE--RSVNTPCPSSLPEINSDLSLVGGSVYPS 487
             .|..:|:...|         .|...::.||.:.|  .|..:...|.||....||:....|:  .
Human   421 KEERMDSARPCL---------HRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSI--E 474

  Fly   488 VTQEVAAVCGECNETD----RNLCSVGGLHMPTSRSMHQLAKKRRNRMASYSGNGSCADSRSSAA 548
            ..:|.||:..|.:|..    ..:...||...|..|.             |..|:.....|.:|::
Human   475 KDKEEAAISRELSEITTAEAEPVVPRGGFDSPFYRD-------------SLPGSQRKTHSAASSS 526

  Fly   549 KKASWSTEAENPMRRTKSCSALSGMRQQHLEENDDEAD--CSSQRQRGENGNTQKTGSRLQRSGR 611
            :.||.:.|   |:.     |:|..:.....::.....|  |.|       .:....|.|..::..
Human   527 QGASVNPE---PLH-----SSLDKLGPDTPKQAFTPIDLPCGS-------ADESPAGDRECQTSL 576

  Fly   612 NLAISAPKDTARSCTHASTQTVEGLDSA-PAQYE------------NWLI----ELLLECKEQRI 659
            ..:|..|     |.......|..|..|. |..|:            :::|    |||.:.|....
Human   577 ETSIFTP-----SPCKIPPPTRVGFGSGQPPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTE 636

  Fly   660 DYERNLLYPQDILDEYIKHAIKA-----------NESFD--------------AEQGQLMCL--Q 697
            :.......|.::||..|:....|           ::|.|              ..:.||:.|  |
Human   637 EDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQ 701

  Fly   698 LEYESYRRSIHAERNRRLMGRSRDKRSLEMERDRLREQLKNFDAKNKDLANKMDQAIRLANERQN 762
            |.||.::|..||.|||||:.:.....:||.....:::|||   .:.||:     |..:::.:::.
Human   702 LLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK---LQEKDI-----QMWKVSLQKEQ 758

  Fly   763 IHQEELGEMR-----------AKYQHELEEKKCLRQANDDLQTRLTSELARHKEMNYELESLRGQ 816
            ....:|.|.|           .:.||:.||   ....:.:|||:|........|:..||:....:
Human   759 ARYNQLQEQRDTMVTKLHSQIRQLQHDREE---FYNQSQELQTKLEDCRNMIAELRIELKKANNK 820

  Fly   817 VFSLGTELQHTQQQADIGLQCKQELARLEAEFIIMGEVQVRCRDRLAEIDNFRARDEELQMLQES 881
            |......|....|:.......:|::..|..:.:::|||.....::|.  :......:|::|::.:
Human   821 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQ--NKHSDTTKEVEMMKAA 883

  Fly   882 SNLELKDLRHSLDEKTSQLESMKHKISDLQAQLANSEKAMTEQKRLLSTVKDEYEEKFKSVNKKY 946
            ...||:..|..:.::|.:|::.:.:|.:|::.||..:..:.|||:.|..||.:...:.::...:|
Human   884 YRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRY 948

  Fly   947 DVQKKIIMQMEEKLM---------------------------------------MMMQQPQGTTG 972
            :.||:|....|.:::                                       .|:...:..:|
Human   949 EAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASG 1013

  Fly   973 HN--TCSPDTDRTDIASSIERNSPLSTSLASSESLSASLRSTELKNLHQLVD------------- 1022
            ||  |.:|       ..|..|.|..|.....|.|.|:.| ||..|..||...
Human  1014 HNGETKTP-------RPSSARGSSGSRGGGGSSSSSSEL-STPEKPPHQRAGPFSSRWETTMGEA 1070

  Fly  1023 TPTIPDVLNSMAGGAQF-----------EDEVRPPAVDLASSASTASAINIVPHALDLPSTSGGI 1076
            :.:||..:.|:.....|           :.|.:.....:.||.|.:....:   ..|| .....|
Human  1071 SASIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTEL---GKDL-GVEAKI 1131

  Fly  1077 GHTLTHPHPHP-------HLHLQQQQQ 1096
            ...|..|||.|       .||:....:
Human  1132 PLNLDGPHPSPPTPDSVGQLHIMDYNE 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsc1	NP_477415.1	Hamartin	3..715	CDD:461287	199/796 (25%)
		Smc	<696..>938	CDD:440809	61/254 (24%)
TSC1	NP_000359.1	Hamartin	7..719	CDD:461287	199/796 (25%)
		Mediates interaction with WDR45B. /evidence=ECO:0000269|PubMed:28561066	403..787		89/435 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..571		33/161 (20%)
		Smc	<708..>960	CDD:440809	60/264 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1006..1085		21/86 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1131..1164		8/28 (29%)