Protein Alignment Tsc1 and Tsc1

DIOPT Version :10

• Sequence 1: NP_477415.1
• Gene: Tsc1 / 42862
• FlyBaseID: FBgn0026317
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: XP_006498283.1
• Gene: Tsc1 / 64930
• MGIID: 1929183
• Length: 1174
• Species: Mus musculus
• Alignment Length: 1246
• Identity: 285/1246 - (22%)
• Similarity: 503/1246 - (40%)
• Gaps: 242/1246 - (19%)

  Fly     3 IEKIIGDLESNMTLENEEAKRKLVELLSQNKEQWVVKFMLDYFFTTGSQRILEVLVKAQAPHDGY 67
            |.:::..|:|:.....::......|.|:..:...:|..::||:..|.||.:|.:|...|.|||.:
Mouse     7 IGELLSMLDSSTLGVRDDVTAIFKESLNSERGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKH 71

  Fly    68 IFDKLDDCLKQSQHRVQSLQVFCFIVRHHPTWLYKIEKHRLIKSVFKLMTHEKEIVPLMSALLCI 132
            :.||:::.:.::..|:..|.:...:||..|:|.:|:.:..|:.|:.|.:..:.::|.|.:.:|.:
Mouse    72 LLDKINEYVGKAATRLSILSLLGHVVRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVL 136

  Fly   133 ITLLPIIPNSVPNFLNDLFEVFGHLASWKLQNSNKLPDEKLVHLQLGLQMLFHRLYGMYPCSFIA 197
            ||:||:||.|....|.|.|::||.|:||.|:....:.:..||||...:..|||||||||||:|::
Mouse   137 ITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVS 201

  Fly   198 YLVEFIKRGNGGGIFQHTIKPLLNTVRVHPMLVTATPETEVNNTRWKEMEPHDVVMECANLSL-P 261
            :|............|:..:||::..||:||.|||.:.:.|::..|||.:|.||||:|||.:|| |
Mouse   202 FLRSHYSMKENVETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKTLETHDVVIECAKISLDP 266

  Fly   262 VLLPETSNEDG-SYAYPMTPGYSRMTSNTSNTDYSYQLREFQQSRNVYTRFDSFASGDDVGPIWS 325
            .   |.|.||| |.::.::..:...:::.:.:.|       ..::|.|....|..|......::|
Mouse   267 T---EASYEDGYSVSHQLSACFPYRSADVTTSPY-------VDTQNSYGGSTSTPSSSSRLMLFS 321

  Fly   326 PHNEIATTSSGIPLTPTTSFI-LPLQPAMNSQ----LMVGMTGSSPPEAAVEATPETTPLKDMRD 385
            |..::..:.|    :|:|..: .|||...:|.    |.:..:..||.......||.|:|.....|
Mouse   322 PPGQLPQSLS----SPSTRLLPEPLQVRCHSACLHLLYLPASLWSPSAVCGMTTPPTSPGNVPAD 382

  Fly   386 IKQP---------GRAVNSHAVRAIFAVSQPSSP-------------------MRKDQQSQFSFP 422
            :..|         |:...|...    |.|.|.:|                   .||::::..|.|
Mouse   383 LSHPYSKAFGTTGGKGTPSGTP----ATSPPPAPPCPQDDCVHGSAAQASATAPRKEERADSSRP 443

  Fly   423 DVSREAEESSHSYLEVNRGTAYDRRLSQVIQDRHNVERSVNTPCPSSLPEINSDLSLVGGSVYPS 487
            .:.|::.:         ||          ::|....:.||..   .:||:...||:....|:  .
Mouse   444 YLHRQSND---------RG----------LEDPPGSKGSVTL---RNLPDFLGDLASEEDSI--E 484

  Fly   488 VTQEVAAVCGECNE-TDRNLCSV---GGLHMPTSRSMHQLAKKRRNRMASYSGN----------G 538
            ..:|.||:..|.:| |......|   ||...|..|.  .|:..:|...::.||.          .
Mouse   485 KDKEEAAISKELSEITTAEADPVVPRGGFDSPFYRD--SLSGSQRKTHSAASGTQGSSVNPEPLH 547

  Fly   539 SCADSRSSAAKKASWSTEAENPMRRTKSCSALSGMRQQHLEEND-DEADCSSQRQRGEN-GNTQK 601
            |..|.......|.:: |..:.|........|....||..||.:. ..:.|....|||.: |:.|
Mouse   548 SSLDKHGPDTPKQAF-TPIDPPSGSADVSPAGDRDRQTSLETSILTPSPCKIPPQRGVSFGSGQ- 610

  Fly   602 TGSRLQRSGRNLAISAPKDTARSCTHASTQTVEGLDSAPAQYENWLIELLLECKEQRIDYERNLL 666
                |........::.||   .:|...|.:|.|.|.......|.       :|...        .
Mouse   611 ----LPPYDHLFEVALPK---TACHFVSKKTEELLKKVKGNPEE-------DCVPS--------T 653

  Fly   667 YPQDILDEYIKHAIKA-----------NESFD--------------AEQGQLMCL--QLEYESYR 704
            .|.::||..|:....|           ::|.|              ..:.||:.|  ||.||.::
Mouse   654 SPMEVLDRLIEQGAGAHSKELSRLSLPSKSVDWTHFGGSPPSDELRTLRDQLLLLHNQLLYERFK 718

  Fly   705 RSIHAERNRRLMGRSRDKRSLEMERDRLREQLKNFDAKNKDLANKMDQAIRLANERQNIHQEELG 769
            |..||.|||||:.:.....:||.....:::|||   .:.||:     |..:::.:::.....:|.
Mouse   719 RQQHALRNRRLLRKVIRAAALEEHNAAMKDQLK---LQEKDI-----QMWKVSLQKEQARYSQLQ 775

  Fly   770 EMR-----------AKYQHELEEKKCLRQANDDLQTRLTSELARHKEMNYELESLRGQVFSLGTE 823
            |.|           .:.||:.||   ....:.:|||:|........|:..||:....:|......
Mouse   776 EQRDTMVTQLHSQIRQLQHDREE---FYNQSQELQTKLEDCRNMIAELRVELKKANNKVCHTELL 837

  Fly   824 LQHTQQQADIGLQCKQELARLEAEFIIMGEVQVRCRDRLAEIDNFRARDEELQMLQESSNLELKD 888
            |....|:.......:|::..|..:.:::|||.....::|.  .......:|::|::.:...||:.
Mouse   838 LSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQ--SKHPDTTKEVEMMKTAYRKELEK 900

  Fly   889 LRHSLDEKTSQLESMKHKISDLQAQLANSEKAMTEQKRLLSTVKDEYEEKFKSVNKKYDVQKKII 953
            .|..|.::..:|::.:.::.:|::.||..:..:.|||:.|..||.:...:..:...:|:.|:||.
Mouse   901 NRSHLLQQNQRLDASQRRVLELESLLAKKDHLLLEQKKYLEDVKSQASGQLLAAESRYEAQRKIT 965

  Fly   954 MQMEEKLM---------------------------------------MMMQQPQGTTGHN----T 975
            ..:|.:::                                       .::...:..:|||    |
Mouse   966 RVLELEILDLYGRLEKDGRLRKLEEDRAEAAEAAEERLDCCSDGCTDSLVGHNEEASGHNGETRT 1030

  Fly   976 CSPDTDRTDIASSIERNSPLSTSLASSESLSASLRSTELKNLHQLVDTPTIPDVLNSMAGGAQF- 1039
            ..|...|......:...|..|:|..|:.....|.|.:..........:.:||..:.|:.....|
Mouse  1031 SRPGGTRASCGGRVTGGSSSSSSELSTPEKPPSQRFSSRWEPALGEPSSSIPTTVGSLPSSKSFL 1095

  Fly  1040 -----------------EDEVRPPAVDLASSAST-----ASAINIVPHALDLP----STSGGIG- 1077
                             ||.|...:..|:.:..|     :...|....:||.|    ..|..:|
Mouse  1096 GMKARELFRNKSESQCDEDSVTMSSSSLSETLKTELGKDSGTENKTSLSLDAPHPSSPNSDNVGQ 1160

  Fly  1078 -HTLTHPHPHP 1087
             |.:.:...||
Mouse  1161 LHIMDYNETHP 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsc1	NP_477415.1	Hamartin	3..715	CDD:461287	201/789 (25%)
		Smc	<696..>938	CDD:440809	60/254 (24%)
Tsc1	XP_006498283.1	Hamartin	7..729	CDD:461287	203/799 (25%)
		SMC_prok_B	<714..>960	CDD:274008	56/256 (22%)