DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tsc1 and Tsc1

DIOPT Version :9

Sequence 1:NP_477415.1 Gene:Tsc1 / 42862 FlyBaseID:FBgn0026317 Length:1100 Species:Drosophila melanogaster
Sequence 2:XP_006498283.1 Gene:Tsc1 / 64930 MGIID:1929183 Length:1174 Species:Mus musculus


Alignment Length:1246 Identity:285/1246 - (22%)
Similarity:503/1246 - (40%) Gaps:242/1246 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IEKIIGDLESNMTLENEEAKRKLVELLSQNKEQWVVKFMLDYFFTTGSQRILEVLVKAQAPHDGY 67
            |.:::..|:|:.....::......|.|:..:...:|..::||:..|.||.:|.:|...|.|||.:
Mouse     7 IGELLSMLDSSTLGVRDDVTAIFKESLNSERGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKH 71

  Fly    68 IFDKLDDCLKQSQHRVQSLQVFCFIVRHHPTWLYKIEKHRLIKSVFKLMTHEKEIVPLMSALLCI 132
            :.||:::.:.::..|:..|.:...:||..|:|.:|:.:..|:.|:.|.:..:.::|.|.:.:|.:
Mouse    72 LLDKINEYVGKAATRLSILSLLGHVVRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVL 136

  Fly   133 ITLLPIIPNSVPNFLNDLFEVFGHLASWKLQNSNKLPDEKLVHLQLGLQMLFHRLYGMYPCSFIA 197
            ||:||:||.|....|.|.|::||.|:||.|:....:.:..||||...:..|||||||||||:|::
Mouse   137 ITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVS 201

  Fly   198 YLVEFIKRGNGGGIFQHTIKPLLNTVRVHPMLVTATPETEVNNTRWKEMEPHDVVMECANLSL-P 261
            :|............|:..:||::..||:||.|||.:.:.|::..|||.:|.||||:|||.:|| |
Mouse   202 FLRSHYSMKENVETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKTLETHDVVIECAKISLDP 266

  Fly   262 VLLPETSNEDG-SYAYPMTPGYSRMTSNTSNTDYSYQLREFQQSRNVYTRFDSFASGDDVGPIWS 325
            .   |.|.||| |.::.::..:...:::.:.:.|       ..::|.|....|..|......::|
Mouse   267 T---EASYEDGYSVSHQLSACFPYRSADVTTSPY-------VDTQNSYGGSTSTPSSSSRLMLFS 321

  Fly   326 PHNEIATTSSGIPLTPTTSFI-LPLQPAMNSQ----LMVGMTGSSPPEAAVEATPETTPLKDMRD 385
            |..::..:.|    :|:|..: .|||...:|.    |.:..:..||.......||.|:|.....|
Mouse   322 PPGQLPQSLS----SPSTRLLPEPLQVRCHSACLHLLYLPASLWSPSAVCGMTTPPTSPGNVPAD 382

  Fly   386 IKQP---------GRAVNSHAVRAIFAVSQPSSP-------------------MRKDQQSQFSFP 422
            :..|         |:...|...    |.|.|.:|                   .||::::..|.|
Mouse   383 LSHPYSKAFGTTGGKGTPSGTP----ATSPPPAPPCPQDDCVHGSAAQASATAPRKEERADSSRP 443

  Fly   423 DVSREAEESSHSYLEVNRGTAYDRRLSQVIQDRHNVERSVNTPCPSSLPEINSDLSLVGGSVYPS 487
            .:.|::.:         ||          ::|....:.||..   .:||:...||:....|:  .
Mouse   444 YLHRQSND---------RG----------LEDPPGSKGSVTL---RNLPDFLGDLASEEDSI--E 484

  Fly   488 VTQEVAAVCGECNE-TDRNLCSV---GGLHMPTSRSMHQLAKKRRNRMASYSGN----------G 538
            ..:|.||:..|.:| |......|   ||...|..|.  .|:..:|...::.||.          .
Mouse   485 KDKEEAAISKELSEITTAEADPVVPRGGFDSPFYRD--SLSGSQRKTHSAASGTQGSSVNPEPLH 547

  Fly   539 SCADSRSSAAKKASWSTEAENPMRRTKSCSALSGMRQQHLEEND-DEADCSSQRQRGEN-GNTQK 601
            |..|.......|.:: |..:.|........|....||..||.:. ..:.|....|||.: |:.| 
Mouse   548 SSLDKHGPDTPKQAF-TPIDPPSGSADVSPAGDRDRQTSLETSILTPSPCKIPPQRGVSFGSGQ- 610

  Fly   602 TGSRLQRSGRNLAISAPKDTARSCTHASTQTVEGLDSAPAQYENWLIELLLECKEQRIDYERNLL 666
                |........::.||   .:|...|.:|.|.|.......|.       :|...        .
Mouse   611 ----LPPYDHLFEVALPK---TACHFVSKKTEELLKKVKGNPEE-------DCVPS--------T 653

  Fly   667 YPQDILDEYIKHAIKA-----------NESFD--------------AEQGQLMCL--QLEYESYR 704
            .|.::||..|:....|           ::|.|              ..:.||:.|  ||.||.::
Mouse   654 SPMEVLDRLIEQGAGAHSKELSRLSLPSKSVDWTHFGGSPPSDELRTLRDQLLLLHNQLLYERFK 718

  Fly   705 RSIHAERNRRLMGRSRDKRSLEMERDRLREQLKNFDAKNKDLANKMDQAIRLANERQNIHQEELG 769
            |..||.|||||:.:.....:||.....:::|||   .:.||:     |..:::.:::.....:|.
Mouse   719 RQQHALRNRRLLRKVIRAAALEEHNAAMKDQLK---LQEKDI-----QMWKVSLQKEQARYSQLQ 775

  Fly   770 EMR-----------AKYQHELEEKKCLRQANDDLQTRLTSELARHKEMNYELESLRGQVFSLGTE 823
            |.|           .:.||:.||   ....:.:|||:|........|:..||:....:|......
Mouse   776 EQRDTMVTQLHSQIRQLQHDREE---FYNQSQELQTKLEDCRNMIAELRVELKKANNKVCHTELL 837

  Fly   824 LQHTQQQADIGLQCKQELARLEAEFIIMGEVQVRCRDRLAEIDNFRARDEELQMLQESSNLELKD 888
            |....|:.......:|::..|..:.:::|||.....::|.  .......:|::|::.:...||:.
Mouse   838 LSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQ--SKHPDTTKEVEMMKTAYRKELEK 900

  Fly   889 LRHSLDEKTSQLESMKHKISDLQAQLANSEKAMTEQKRLLSTVKDEYEEKFKSVNKKYDVQKKII 953
            .|..|.::..:|::.:.::.:|::.||..:..:.|||:.|..||.:...:..:...:|:.|:||.
Mouse   901 NRSHLLQQNQRLDASQRRVLELESLLAKKDHLLLEQKKYLEDVKSQASGQLLAAESRYEAQRKIT 965

  Fly   954 MQMEEKLM---------------------------------------MMMQQPQGTTGHN----T 975
            ..:|.:::                                       .::...:..:|||    |
Mouse   966 RVLELEILDLYGRLEKDGRLRKLEEDRAEAAEAAEERLDCCSDGCTDSLVGHNEEASGHNGETRT 1030

  Fly   976 CSPDTDRTDIASSIERNSPLSTSLASSESLSASLRSTELKNLHQLVDTPTIPDVLNSMAGGAQF- 1039
            ..|...|......:...|..|:|..|:.....|.|.:..........:.:||..:.|:.....| 
Mouse  1031 SRPGGTRASCGGRVTGGSSSSSSELSTPEKPPSQRFSSRWEPALGEPSSSIPTTVGSLPSSKSFL 1095

  Fly  1040 -----------------EDEVRPPAVDLASSAST-----ASAINIVPHALDLP----STSGGIG- 1077
                             ||.|...:..|:.:..|     :...|....:||.|    ..|..:| 
Mouse  1096 GMKARELFRNKSESQCDEDSVTMSSSSLSETLKTELGKDSGTENKTSLSLDAPHPSSPNSDNVGQ 1160

  Fly  1078 -HTLTHPHPHP 1087
             |.:.:...||
Mouse  1161 LHIMDYNETHP 1171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tsc1NP_477415.1 Hamartin 3..715 CDD:282270 201/789 (25%)
KASH_CCD 736..915 CDD:291334 36/189 (19%)
Tsc1XP_006498283.1 Hamartin 7..729 CDD:367919 203/799 (25%)
Smc 715..>981 CDD:224117 61/319 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841857
Domainoid 1 1.000 199 1.000 Domainoid score I3067
eggNOG 1 0.900 - - E1_2CAZQ
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 255 1.000 Inparanoid score I3167
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47070
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004719
OrthoInspector 1 1.000 - - oto93096
orthoMCL 1 0.900 - - OOG6_108503
Panther 1 1.100 - - LDO PTHR15154
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5359
SonicParanoid 1 1.000 - - X4416
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.790

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