Protein Alignment Tsc1 and Tsc1

DIOPT Version :10

• Sequence 1: NP_477415.1
• Gene: Tsc1 / 42862
• FlyBaseID: FBgn0026317
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: XP_063140537.1
• Gene: Tsc1 / 60445
• RGDID: 620124
• Length: 1198
• Species: Rattus norvegicus
• Alignment Length: 1266
• Identity: 288/1266 - (22%)
• Similarity: 504/1266 - (39%)
• Gaps: 253/1266 - (19%)

  Fly     3 IEKIIGDLESNMTLENEEAKRKLVELLSQNKEQWVVKFMLDYFFTTGSQRILEVLVKAQAPHDGY 67
            |.:::..|:|:.....::......|.|:..:...:|..::||:..|.||.:|.:|...|.|||.:
  Rat     7 IGELLSMLDSSTLGVRDDVTTIFKESLNSERGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKH 71

  Fly    68 IFDKLDDCLKQSQHRVQSLQVFCFIVRHHPTWLYKIEKHRLIKSVFKLMTHEKEIVPLMSALLCI 132
            :.||:::.:.::..|:..|.:...:||..|:|.:|:.:..|:.|:.|.:..:.::|.|.:.:|.:
  Rat    72 LLDKMNEYVGKAATRLSILSLLGHVVRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVL 136

  Fly   133 ITLLPIIPNSVPNFLNDLFEVFGHLASWKLQNSNK------------------------------ 167
            ||:||:||.|....|.|.|::||.|:||.|:...:
  Rat   137 ITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGRVKQSGVCPRIPWCVLNRGMWCIQMYICLTF 201

  Fly   168 -----LPDEKLVHLQLGLQMLFHRLYGMYPCSFIAYLVEFIKRGNGGGIFQHTIKPLLNTVRVHP 227
                 :.:..||||...:..|||||||||||:|:::|............|:..:||::..||:||
  Rat   202 LEPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENVETFEEVVKPMMEHVRIHP 266

  Fly   228 MLVTATPETEVNNTRWKEMEPHDVVMECANLSL-PVLLPETSNEDG-SYAYPMTPGYSRMTSNTS 290
            .|||.:.:.|::..|||.:|.||||:|||.:|| |.   |.|.||| :.::.::..:...:::.:
  Rat   267 ELVTGSKDHELDPRRWKTLETHDVVIECAKISLDPT---EASYEDGDAVSHQLSACFPHRSADVT 328

  Fly   291 NTDYSYQLREFQQSRNVYTRFDSFASGDDVGPIWSPHNEIATTSSGIPLTPTTSFILPLQPAMNS 355
            .:.|       ..::|.|....|..|......::|...::..:.|.:...|...   |||.::.|
  Rat   329 TSSY-------VDTQNSYGGATSTPSSTSRLMLFSTPGQLPQSLSSLSTRPLPE---PLQASLWS 383

  Fly   356 QLMV-GMTGSSPPEAAVEATPETTPLKDMRDIKQP----------GRAVNSHAVRAIFAVSQPSS 409
            ...| |||           ||.|:|.....|:..|          |:...|...    |.|.|.:
  Rat   384 PSAVCGMT-----------TPPTSPGNVPADLSHPYSKAFGTTTGGKGTPSGTP----ATSPPPA 433

  Fly   410 P------MRKDQQSQFS-FPDVSREAEESSHSYLEVNRGTAYDRRLSQVIQDRHNVERSVNTPCP 467
            |      ......||.| .|....|..:||..||...:....||.|    :|....:.||..
  Rat   434 PPCPQDDCAHGPASQASATPPRKEERADSSRPYLPRQQDVPSDRGL----EDLPGSKGSVTL--- 491

  Fly   468 SSLPEINSDLSLVGGSVYPSVTQEVAAVCGECNE-TDRNLCSV---GGLHMPTSRSMHQLAKKRR 528
            .:||:...||:....|:  ...:|.||:..|.:| |......|   ||...|..|.....::::.
  Rat   492 RNLPDFLGDLASEEDSI--EKDKEEAAISKELSEITTAEADPVAPRGGFDSPFYRDSLSGSQRKT 554

  Fly   529 NRMAS----YSGN----GSCADSRSSAAKKASWSTEAENPMRRTKSCSALSGMRQQHLEEND-DE 584
            :..||    :|.|    .|..|.......|.:: |..:.|.....:..|....||..||.:. ..
  Rat   555 HSAASGTQGFSVNPEPLHSSLDKHGPDTPKQAF-TPIDPPSGSADASPAGDRDRQTSLETSILTP 618

  Fly   585 ADCSSQRQRGEN-GNTQKTGSRLQRSGRNLAISAPKDTARSCTHASTQTVEGLDSAPAQYENWLI 648
            :.|....|||.: |:.|     |........::.||   .:|...|.:|.|.|..|....|.
  Rat   619 SPCKIPPQRGVSFGSGQ-----LPPYDHLFEVALPK---TACHFVSKKTEELLKKAKGNPEE--- 672

  Fly   649 ELLLECKEQRIDYERNLLYPQDILDEYIKHAIKA-----------NESFD--------------A 688
                :|...        ..|.::||..::....|           ::|.|              .
  Rat   673 ----DCVPS--------TSPMEVLDRLLEQGAGAHSKELSRLSLPSKSVDWTHFGGSPPSDEIRT 725

  Fly   689 EQGQLMCL--QLEYESYRRSIHAERNRRLMGRSRDKRSLEMERDRLREQLKNFDAKNKDLANKMD 751
            .:.||:.|  ||.||.::|..||.|||||:.:.....:||.....:::|||   .:.||:
  Rat   726 LRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRAAALEEHNAAMKDQLK---LQEKDI----- 782

  Fly   752 QAIRLANERQNIHQEELGEMR-----------AKYQHELEEKKCLRQANDDLQTRLTSELARHKE 805
            |..:::.:::.....:|.:.|           .:.||:.||   ....:.:|||:|....:...|
  Rat   783 QMWKVSLQKEQARYSQLQQQRDTMVTQLHSQIRQLQHDREE---FYNQSQELQTKLEDCRSMIAE 844

  Fly   806 MNYELESLRGQVFSLGTELQHTQQQADIGLQCKQELARLEAEFIIMGEVQVRCRDRLAEIDNFRA 870
            :..||:....:|......|....|:.......:|::..|..:.:::|||.....::|.  .....
  Rat   845 LRVELKKANSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQ--SKHPD 907

  Fly   871 RDEELQMLQESSNLELKDLRHSLDEKTSQLESMKHKISDLQAQLANSEKAMTEQKRLLSTVKDEY 935
            ..:|::|::.:...||:..|..|.::..:|::.:.::.:|::.||..:..:.|||:.|..||.:.
  Rat   908 TTKEVEMMKTAYRKELEKNRSHLLQQNQRLDASQRRVLELESLLAKKDHLLLEQKKYLEDVKSQA 972

  Fly   936 EEKFKSVNKKYDVQKKIIMQMEEKLM--------------------------------------- 961
            ..:..:...:|:.|:||...:|.:::
  Rat   973 SGQLLAAESRYEAQRKITRVLELEILDLYGRLEKDGRLQKLEEDRAEAAEAAEERLDCCTDGCSD 1037

  Fly   962 MMMQQPQGTTGHN----TCSPDTDRTDIASSIERNSPLSTSLASSESLSASLRSTELKNLHQLVD 1022
            .::...:...|||    |..|...|......:...|..|:|..|:.....:.|.:..........
  Rat  1038 SLLGHNEEAAGHNGETRTSRPGGTRASCGGRVTGGSSSSSSELSTPEKPPNQRFSSRWEPTMGEP 1102

  Fly  1023 TPTIPDVLNSMAGGAQF-------------EDEVRPPAVDLASSAST---------ASAINIVPH 1065
            :.:||..:.|:.....|             |.:.....:.::|.:.|         |...|..|.
  Rat  1103 SSSIPTTVGSLPSSKSFLGMKTRELFRNKSESQCDEDGMTMSSFSETLKTELGKDSAGMENKTPP 1167

  Fly  1066 ALDLP------STSGGIGHTLTHPHPHPHLH 1090
            :||.|      |.|.|..|.:.:...| |.|
  Rat  1168 SLDAPHPSSPSSDSMGQLHIMDYNETH-HEH 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsc1	NP_477415.1	Hamartin	3..715	CDD:461287	204/807 (25%)
		Smc	<696..>938	CDD:440809	59/254 (23%)
Tsc1	XP_063140537.1	None