DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsc1 and tsc1a

DIOPT Version :9

Sequence 1:	NP_477415.1	Gene:	Tsc1 / 42862	FlyBaseID:	FBgn0026317	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	XP_005171852.1	Gene:	tsc1a / 337167	ZFINID:	ZDB-GENE-030131-9111	Length:	1137	Species:	Danio rerio

Alignment Length:	1152	Identity:	290/1152 - (25%)
Similarity:	508/1152 - (44%)	Gaps:	210/1152 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ENEEAKRKLVELLSQNKEQWVVKFMLDYFFTTGSQRILEVLVKAQAPHDGYIFDKLDDCLKQSQH 81
            |.|:.|..|.|.||.:|...::..::|||..|.|.:.:::|...:.|||.|:.||:::|:.:...
Zfish    22 ELEQVKTLLQETLSADKGTMLLNSLVDYFLQTNSSQAVDILSSVREPHDKYLLDKMNECMGKQSC 86

  Fly    82 RVQSLQVFCFIVRHHPTWLYKIEKHRLIKSVFKLMTHEKEIVPLMSALLCIITLLPIIPNSVPNF 146
            |:.::.:...:||..|.|::||.:..|:.|:.|.:..:.::|.|::.:|.:|||:|:||.:....
Zfish    87 RLSTITLLGHVVRKQPPWIHKIARFPLLVSLLKCLKTDSDVVVLITGVLVLITLMPMIPQTNKQL 151

  Fly   147 LNDLFEVFGHLASWKLQNSNKLPDEKLVHLQLGLQMLFHRLYGMYPCSFIAYLVEFIKRGNGGGI 211
            |.|.|::||.||:|..::.........|||...:..|||||||||||:|::||............
Zfish   152 LCDYFDIFGRLAAWNQRHPGHAQGVFAVHLHASVYSLFHRLYGMYPCNFVSYLRAHYSMKENVDT 216

  Fly   212 FQHTIKPLLNTVRVHPMLVTATPETEVNNTRWKEMEPHDVVMECANLSLPVLLPETSNEDG---- 272
            |:..:||:|..||:||.|:|.|.:.||:..|||..||||:|:|||.:||.  ..|.|:|:|
Zfish   217 FEEVVKPMLEHVRIHPELITGTKDYEVDPIRWKRFEPHDIVIECAKISLD--SKEASSEEGYSSL 279

  Fly   273 -SYAYPMTPGYSRMTSNTSNTDYS---------YQLREFQ-----------QSRNVYTRFDSFAS 316
             .:.......:|:..|..|..:.|         ..|.:.|           .::.:..:.|...|
Zfish   280 ADHIQRRAVHHSQSCSELSFHEISSVTPIGAICQSLSKSQPYLTVTQDSGSSAQTLNNQSDEVKS 344

  Fly   317 GDDVGPIWSPHN--EIATTSSGIPLTPTTSFILPLQPAMNSQLMVGMTGSSPPEAAVEATPET-- 377
            ......:|||.:  .::|..|...::|||...:    ::::..:.|...|:|.:.....:|.|
Zfish   345 SGMKEELWSPSSICGMSTPPSSRGMSPTTVSDI----SLSASHLSGRIPSTPGDGKWTLSPTTPS 405

  Fly   378 --TPLKDM-RDIKQPGRAVNSHAVRAIFAVSQPSSPMRKDQQSQFSFPDVSREAEESSHSYLEVN 439
              :||..: .:|.|..:..:|...:....|.:.:                ||....||.     |
Zfish   406 GSSPLPSLSEEIGQAAQNTSSTQAKTCKEVKKVT----------------SRSINNSSE-----N 449

  Fly   440 RGTAYD----RRLSQVIQDRHNVERSVNTPCPSSLPEINSD-LSLVGGSVYPSVTQEVAAVCGEC 499
            .|.|..    .:||.::: |...||..:|        ||.: |||..|.:
Zfish   450 GGDAKTPVSLAQLSDIVK-RTEGEREDDT--------INEEILSLTHGKL--------------- 490

  Fly   500 NETDRNLCSVGGLHMPTSRSMHQLAKKRRN---RMASYSGNGSC-ADSRSSAAKKASWS-TEAEN 559
                 :..|..||....|.|:..|.....|   .:.|......| |.:......::.|. |..||
Zfish   491 -----DFGSRPGLESSFSGSLDTLLSSHPNHEQNLVSTPDRVECSAKAGEQQLPRSLWPFTPIEN 550

  Fly   560 PMRRTKSCS-----------------ALSGMRQQHLEENDDEADCSSQRQRGENGNTQKTGSRLQ 607
              .:...||                 ||..:....||....||   .:|..||..:..      :
Zfish   551 --GKHSKCSLSDLTKESMPYEPLFDLALPKVASLFLERKTAEA---FRRVEGERDHQD------E 604

  Fly   608 RSGRNLAISAPKDTARSCTHASTQTVEGLDSAPAQYENWLIELLLECKEQRIDYERNLLYPQDIL 672
            ..|.:|::::|              :|.||....|..:...::|          :|....|....
Zfish   605 MEGEDLSVTSP--------------LEVLDRVIQQGHDTHGKVL----------KRTFSSPSQSS 645

  Fly   673 DEYIK---HAIK-------ANESFDAEQGQLMCL--QLEYESYRRSIHAERNRRLMGRSRDKRSL 725
            |.::|   |:.|       .::..|..:.||:.|  ||.||.::|..||.|||||.||..:..:|
Zfish   646 DPHLKGKQHSNKGKGLVPAVSDELDMLRSQLLLLHNQLLYERHKREQHALRNRRLFGRIVNTTAL 710

  Fly   726 EMERDRLREQLKNFDAKNKDLANKMDQAIRLA---NERQNIH-QEELGEMRAKYQHELEEKKCLR 786
            |.:.:.::.|||        |.....||::::   .:|:::| ||:...:..:.|.::::   |:
Zfish   711 EEQNNSMKTQLK--------LQEVEIQAVKVSLKEEQRRSVHIQEDREAVVNQLQIQIQQ---LQ 764

  Fly   787 QANDDLQTR---LTSELARHK----EMNYELESLRGQVFSLGTELQHTQQQADIGL----QCKQE 840
            :..:|..::   |.|||..::    :|..||:....:|.::|    |...|..|.|    ..:|:
Zfish   765 KERNDYYSKMQVLKSELQENQTKAGKMEAELQKANNKVCNMG----HMLSQLSIKLNNSENMEQQ 825

  Fly   841 LARLEAEFIIMGEVQVRCRDRLAEIDNFRAR-DEELQMLQESSNLELKDLRHSLDEKTSQLESMK 904
            :|.|..:.:::||..   :..:.|||..... .:||.|||.||..|.:.||.|..:::.:||:.:
Zfish   826 MAFLNKQLLLLGEAN---KLYMEEIDRLGPEAHKELNMLQASSVREGERLRQSSLQQSQRLEAAQ 887

  Fly   905 HKISDLQAQLANSEKAMTEQKRLLSTVKDEYEEKFKSVNKKYDVQKKIIMQMEEKLMMMMQQPQG 969
            .:|:||:.||...|:.:.|||:||..||.:..|:.::...:|..||.|...::.:|:.:..:.:
Zfish   888 QRITDLENQLTKKEQVIREQKKLLDNVKRQATEQLQASENRYLAQKNITQALQTELLELYSKIE- 951

  Fly   970 TTGHNTCSPDTDRTDIASSIERNSPLSTSLASSESLSASLRSTELKNLHQLVD---TPTIPDVLN 1031
            .....|.:|....:|.:|...:....:::..|:.||.|.|...| :..|..|:   :...|....
Zfish   952 LKNLKTNAPAESISDPSSPTNQRPNGNSAGPSAPSLPADLMKRE-EGAHVCVNGEISAASPQTPT 1015

  Fly  1032 SMAGGAQFEDEVRPPAVDLASSASTASAINIVPHAL-DLPSTSGGIG 1077
            ::..|:|.|        ||::.:.:..::...|.|: ..|||...:|
Zfish  1016 ALINGSQEE--------DLSALSHSFPSLPCQPFAVGSYPSTRSFLG 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsc1	NP_477415.1	Hamartin	3..715	CDD:282270	194/768 (25%)
Tsc1	NP_477415.1	KASH_CCD	736..915	CDD:291334	50/194 (26%)
tsc1a	XP_005171852.1	Hamartin	8..700	CDD:282270	194/768 (25%)
tsc1a	XP_005171852.1	Ax_dynein_light	<857..943	CDD:287215	31/85 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586329
Domainoid	1	1.000	235	1.000	Domainoid score	I2302
eggNOG	1	0.900	-	-		E1_2CAZQ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2529
OMA	1	1.010	-	-		QHG47070
OrthoDB	1	1.010	-	-		D131264at2759
OrthoFinder	1	1.000	-	-		FOG0004719
OrthoInspector	1	1.000	-	-		otm24294
orthoMCL	1	0.900	-	-		OOG6_108503
Panther	1	1.100	-	-	O	PTHR15154
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4416
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860