Protein Alignment Tsc1 and tsc1b

DIOPT Version :9

• Sequence 1: NP_477415.1
• Gene: Tsc1 / 42862
• FlyBaseID: FBgn0026317
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: NP_001269321.1
• Gene: tsc1b / 100330617
• ZFINID: ZDB-GENE-030131-3404
• Length: 1228
• Species: Danio rerio
• Alignment Length: 1224
• Identity: 286/1224 - (23%)
• Similarity: 512/1224 - (41%)
• Gaps: 309/1224 - (25%)

  Fly     7 IGD----LESNMTLENEEAKRKLVELLSQNKEQWVVKFMLDYFFTTGSQRILEVLVKAQAPHDGY 67
            :||    ||::...:..|.|..:.|.|:.::...::..::|||..|.|.:.:.:|...:.|||.:
Zfish     8 VGDLLPLLETSDLRQLNEIKGLINEHLNTDRGSVLLNGLVDYFLETNSAQTVHILSSVREPHDKH 72

  Fly    68 IFDKLDDCLKQSQHRVQSLQVFCFIVRHHPTWLYKIEKHRLIKSVFKLMTHEKEIVPLMSALLCI 132
            :|||:::|:.::..|:.:|.:...:||..|:|::||..:.|:.|:.|.:..:.::|.|::.:|.:
Zfish    73 LFDKMNECMAKAPCRLPTLTLLGHVVRKQPSWIHKIAHYPLLLSLLKCLKTDTDVVVLITGVLVL 137

  Fly   133 ITLLPIIPNSVPNFLNDLFEVFGHLASWKLQNSNKLPDEKLVHLQLGLQMLFHRLYGMYPCSFIA 197
            |||||:||.:....|.:.|::||.||||.|:|...:|:..|:||...:..|||||||||||:|::
Zfish   138 ITLLPMIPQAGKQHLYEFFDIFGRLASWNLRNPGHVPEVYLIHLHASVYSLFHRLYGMYPCNFVS 202

  Fly   198 YLVEFIKRGNGGGIFQHTIKPLLNTVRVHPMLVTATPETEVNNTRWKEMEPHDVVMECANLSLPV 262
            ||............|:..:||:|..||:||.|||.|.:.|::.:|||..|.||:|:|||.:||..
Zfish   203 YLRSHYSMKENMDTFEEVVKPMLEHVRIHPELVTGTKDQELDPSRWKRFEIHDIVIECAKVSLDP 267

  Fly   263 LLPETSNEDGSYAYP---------------MTP--------GYSRMT---------------SNT 289
              .|.|.|:|..:.|               .:|        |.|..|               |:.
Zfish   268 --KEASCEEGYASMPEHFCAHLQQRPADCTASPYGDFHSSYGSSSSTHFSTPRQPVVPPLALSSI 330

  Fly   290 SNTDYSYQLREFQQSRNVYTRFDSFASGDDVGPIWSPHNE--IATTSSGIPLTPT-----TSFIL 347
            |.|...|:.....:.:|....|::.....|  .:|||.::  :||..|...::|.     ::..|
Zfish   331 SGTQPPYRSPTGTRRQNSSCEFNATYGVKD--SLWSPSSQCGMATPPSSRGMSPNPELSQSASHL 393

  Fly   348 PLQ----PAMNSQLMVGMTGSSPPEAAVE-----------ATPETT---PLKD------------ 382
            |.:    ||...    |...||.|.||..           :||.:|   |.||
Zfish   394 PSRLYSTPAGGK----GTPSSSTPAAATPPPSLSDEYPPVSTPRSTASPPCKDGRPLDHIKPVLV 454

  Fly   383 ----MRDIKQPGRAVNSH----AVRAIFAVSQPSSPMRKDQQSQFSFPDVSREAEESSHSYLEVN 439
                :|:.::.|....:|    .......:::.|..|::.:|.:     :.:|.|:::.:. |:.
Zfish   455 RQEQLRESEKTGPETMNHRDGRGENMPMTLTELSVYMKEQEQLR-----IEKEREDAAITE-ELL 513

  Fly   440 RGTAYDRRL-------SQVIQDRHNVERSVNTPCPSSLPEINSDLSLVGGSVYPSVTQEVAAVCG 497
            :.|...|.|       |........:..:...|.|||:  :::.:|.      |..|
Zfish   514 KLTEEKRDLAGLRGFDSPFFSTTETLTGAQQKPLPSSI--LHNTIST------PDKT-------- 562

  Fly   498 ECNETDRNLCSVG----------GLHMPTSRSMHQLAKKRRNRMASYSGN-----GSCADSRSSA 547
            |...:|:...|.|          .:.||.....|.|.    :|..|...:     |.|:   .|.
Zfish   563 EITPSDKGRVSRGPSQEQPWSFQPVFMPIEHPTHSLL----HRSPSAPDDEALKFGLCS---PSP 620

  Fly   548 AKKASWSTEAENPMRRTKSCSALSGMRQQHLEENDDEADCSSQR-QRGENGNTQKTGSRLQRSGR 611
            .|......||...|...::.|...|.:...:.:.     .:.:| |||::|          |.|.
Zfish   621 CKPPPMPYEALFDMALPRAASLFVGRKTSEIVQR-----VAMERFQRGDSG----------RQGE 670

  Fly   612 NLAISAPKDTARSCTHASTQTVEGLDSAPAQYENWLIELLLECKEQRIDYERNLLYPQDILDEYI 676
            :                  :.|||:.||..      :|:|          :|.:....|..|:.:
Zfish   671 D------------------EGVEGVASASP------LEVL----------DRLVQQGGDAHDKVL 701

  Fly   677 KHAIKANESFD--------------AEQGQLMCL--QLEYESYRRSIHAERNRRLMGRSRDKRSL 725
            |.....::|.|              ..:.||:.|  ||.||.|:|..||.|||||:.|..:..:|
Zfish   702 KRLPLPSKSADWTHFGGSAPLDELHTLRSQLLLLHNQLLYERYKREQHAVRNRRLLRRIINATAL 766

  Fly   726 EMERDRLREQLKNFDAKNKDLANKMDQAIRLANERQNIHQEELGEMRAKYQHELEEKKC------ 784
            |.:.:.:::||..             |::.:.:.|:::..|:     .:|:...::::.
Zfish   767 EEQNNAMKDQLNL-------------QSVDILSLRESLQVEQ-----QRYRQLWDDRETVVTRLH 813

  Fly   785 -----LRQANDD-------LQTRLTSELARHKEMNYELESLRGQVFSLGTELQHTQQQADIGLQC 837
                 |:||.||       ||::|.....|..||..||:....:|...|..|.....:.......
Zfish   814 SQIRQLQQARDDYYTKNQELQSKLQECQKRIGEMEAELQKANNEVCHTGHLLNQLTAKLSSSESI 878

  Fly   838 KQELARLEAEFIIMGEVQVRCRDRLAEIDNFRARDEELQMLQESSNLELKDLRHSLDEKTSQLES 902
            :|:|:.|..:.:::||....|...|.:.....::  |:||||.|...|.:.|:.:|..::.:|::
Zfish   879 QQQLSFLNKQLLLLGEAHKLCVQELHQAGPDTSK--EVQMLQTSWGKETERLKQNLLLQSQKLDA 941

  Fly   903 MKHKISDLQAQLANSEKAMTEQKRLLSTVKDEYEEKFKSVNKKYDVQKKIIMQMEEKLMMMMQQP 967
            .:.::::|:.||:..|..:.|||:.|..||.:.:.:.::...:|..|:::.:.::.:|:.:.
Zfish   942 AQQRVAELETQLSKKEHLIAEQKKFLEDVKAQAKGELQASESRYQAQRRVTLALQTELLQLY--- 1003

  Fly   968 QGTTGHNTCSPDTDRTDIASSIE-RNSPLSTSLASSESLSASLRSTELKNLHQLVDTPTIPDVLN 1031
                               |.:| .:|..:.|...:|.::....:||             |.|:
Zfish  1004 -------------------SRLETEDSSAADSALQAEGVTEPCITTE-------------PSVI- 1035

  Fly  1032 SMAGGAQFEDEVRPPAVDLASSASTASAINIVPHALDLPSTSGGIGHTLTHPHP 1085
             :.|||                ..||:..:..||     .:..|.|.||:..||
Zfish  1036 -VVGGA----------------IKTATKEDGKPH-----QSPRGYGSTLSPGHP 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsc1	NP_477415.1	Hamartin	3..715	CDD:282270	207/833 (25%)
		KASH_CCD	736..915	CDD:291334	40/196 (20%)
tsc1b	NP_001269321.1	Hamartin	8..751	CDD:282270	203/828 (25%)
		Lebercilin	811..1007	CDD:292252	47/219 (21%)
		SPEC	831..>990	CDD:295325	40/160 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586328
Domainoid	1	1.000	235	1.000	Domainoid score	I2302
eggNOG	1	0.900	-	-		E1_2CAZQ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2529
OMA	1	1.010	-	-		QHG47070
OrthoDB	1	1.010	-	-		D131264at2759
OrthoFinder	1	1.000	-	-		FOG0004719
OrthoInspector	1	1.000	-	-		otm24294
orthoMCL	1	0.900	-	-		OOG6_108503
Panther	1	1.100	-	-	LDO	PTHR15154
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5359
SonicParanoid	1	1.000	-	-		X4416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.890