Protein Alignment Root and CROCC

DIOPT Version :9

• Sequence 1: NP_001287497.1
• Gene: Root / 42860
• FlyBaseID: FBgn0039152
• Length: 2048
• Species: Drosophila melanogaster
• Sequence 2: XP_011540770.2
• Gene: CROCC / 9696
• HGNCID: 21299
• Length: 2151
• Species: Homo sapiens
• Alignment Length: 2003
• Identity: 554/2003 - (27%)
• Similarity: 986/2003 - (49%)
• Gaps: 238/2003 - (11%)

  Fly    87 DPSALLRQNQELRQRLADESHSYRRRLDTYKQAQHNQANLVSRLQSKIQQYRQRCSDLEERMHET 151
            :|..|:||:.|||::|.:|..||||:|..|::.|..||.||.|||.||.||::|||:||:::.|
Human   267 EPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLE- 330

  Fly   152 IKPTAGVGPKLTTGPTNQVLCSTSLTLGQSSLPCSSSLDSPPPSCSRDYVDDVLVTGGGAGAAEL 216
                                  .|..|.|..|..:..        |:| ::..|:
Human   331 ----------------------RSGELEQQRLRDTEH--------SQD-LESALI---------- 354

  Fly   217 CRKLEEEHQRCEQIVAQNSALRQQLEESNRTNEALTNDLQKLTNDWASLRDELLIKEDEFKEEEQ 281
              :||||.||...:...|:.||:||:::...|:||:.|::|:||||...|.||..:|..::.||:
Human   355 --RLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEE 417

  Fly   282 AFKDYYNSEHNRLLKMWREVVAVKRSFKEMQTAMKAEVAKMGQEINCVGKDIN----GSNATVAF 342
            :|..|:::||:|||.:||:||..:|...|::...:.::.::|.|:....:.:.    |.:..:..
Human   418 SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRL 482

  Fly   343 AVQQAKRA--------------------ADDELKQSQRSND----ELQNQLATLKVQYESARHEI 383
            |..:|:.|                    .:.:|.|.|..:|    :|..::..|.:..:....:.
Human   483 AESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQN 547

  Fly   384 MERDQRLLELMNQLKKLEDRCAQAESQAALASRYSDEIERLNNSMREIAQAVVQDAEN------A 442
            :|:||...:|..:|:.||.  .:.:.||||.   :::.|.|..::|::||||:.|:|:      :
Human   548 LEKDQVNKDLTEKLEALES--LRLQEQAALE---TEDGEGLQQTLRDLAQAVLSDSESGVQLSGS 607

  Fly   443 DREADAEVTGGVMQHMHLTRDAASVVGGAGGAGS------TAGGGGKSPRRNSTRASQAFAEGTI 501
            :|.|||  :.|.::             |..|..:      ::.|.|:||||..:.|..  ...|:
Human   608 ERTADA--SNGSLR-------------GLSGQRTPSPPRRSSPGRGRSPRRGPSPACS--DSSTL 655

  Fly   502 SAVQAALHKYQLALHDMQVKFQNTSETLRTTKAQLETSEGTKQLLTTKMQQLTEKLDSSNSKLSE 566
            :.:.:||||.||.:.||:.:::.:.:.|.|.:.||..||..::.|..::|:|.:|.|.:
Human   656 ALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGA------ 714

  Fly   567 LLQERESLQRGLDDIR-----VQKQQSEMGRA--DINSAFENLSSDYEKMQLNCGKLQKRIDSME 624
             :|..|..||.:..:|     :.:::|.:..:  ......|.|..:.||:|....:|:::.|.:|
Human   715 -MQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE 778

  Fly   625 EDKKAVELEIQRILKDKNITELNLRSEEDRSSRLREETISLREELNRVSLNRDLLEQQRIESDNL 689
            |:::....:..|:.::...:...|...|.:.|.|.:|.:.:||.|:|.:|.||:|:.::.|....
Human   779 EEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 843

  Fly   690 INLLEKQKSDLEYDLDKLLLEKCDLQEKHEKLSNNSCSTSDELKSVQNCLQEAQEERKKLRIQSV 754
            :...|..:.:||..:.||..|:..||:...|||..:.|.:.:...:...:.:.:||:..|:.:..
Human   844 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQR 908

  Fly   755 DQCNEIGELKKELAILDKARLELETDNLSAGEKLKCLQLEKEKILQDLACVTRDRGDIHNQLTAM 819
            ....|....::|...|::.|||.|.........|:..:..:|.:.|.|..:..:|..:..||..:
Human   909 QAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL 973

  Fly   820 CRKKEALNEELMRTRQRLEQTTETNSRLNRNLEEMVKDVEEKQVVIDLHEKDTHRLNELLAALRS 884
            .|:.....:||.:.|:..::..|...|..|..|.:.|:.....|.:...|::...|:|....||.
Human   974 SRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRL 1038

  Fly   885 EKESLESVLFDTNTSLEATEERRSQLERDLQEALVREESLKNHVARLQKELEQCQRKAQETK--- 946
            |||:||..||:....|...|.||.|||.:.|..|:.:|:|...:|.|::::...|.||...|
Human  1039 EKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 1103

  Fly   947 -TQLLNAARAAESDFNQKIA----NLQAC--AEEAAKRHGE-EILQLRNALEKRMQQALQALQTA 1003
             .:|:.|.|.|::...::.|    :||..  .:|||.|..| |..||::.|::..::.|..|:..
Human  1104 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAE 1168

  Fly  1004 KDDEIEKLQERLATLQAHLESLVQQHEEALIRAESEKQQALLIAHRDKQAVAERLEAVSRDLKTE 1068
            |    |:|.|.:|.||       |:.:|.|:.|||||||||.:...:|.|::|:|......|.|.
Human  1169 K----EELSEEIAALQ-------QERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATI 1222

  Fly  1069 QESLDRSRREANARDEKQRAAIAQLKDEMVQMRTKEEEHKIKLEECIRKQELQLSSLREERESLC 1133
            ...::|.:|:|.:|.|:.|:.:..|..|:..:|.:.||......:.:|:.:.|...|.::|:|..
Human  1223 SLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCL 1287

  Fly  1134 RVSEELKMEIRLKEDRMESTNNELQDALRKSKEGEGFIDSLRKELTDCRRQLADSNIERDKYSGS 1198
            |.:|||:.::||.||..:....||.:|.||.:|.:...:..|:|..:.||.|.:...||:....|
Human  1288 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRS 1352

  Fly  1199 NKELRDHVKRVESAKREQARAIEEALQKISNLEDTKNSLENERTRLSTILKETENHFTKTTQDLN 1263
            |:|||..||:.||.:.....|.|:..||::.||:.:.::..|...|.|.|:|.|....:..::|.
Human  1353 NEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQ 1417

  Fly  1264 ATKAQLQKAQVEFAQKDEGGKELQCKLVAEVELKERAQQELCQIKKQLSDLEANLCATRQELGRA 1328
            ..:.|::....|..:......|||.:|......::.:::|...::::|...||:|...||||..|
Human  1418 ELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVA 1482

  Fly  1329 RCQNNQEEHRFHAREQELAQRLEEGRGREKRLEDQKHNLEVCLADATQQIQELKARLGGAEGRIR 1393
            :.:..::|..|..||:.|...|||.||.||:..|....||:.|..|..:..||..||..||||.:
Human  1483 QRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQ 1547

  Fly  1394 ALDEQLSCVELHKRDTEQKLSSVVHTLRRIAGI---------QVDGSVNLSHRLLSPSRRFSPSR 1449
            .|:.:|:.||:.:|..|.:|..:...|||..|:         .|.|         ||:|. :|:.
Human  1548 GLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPG---------SPARD-APAE 1602

  Fly  1450 SCGD-YDNRSTSQC--------------PDGPIDVDPDLVRKGVRNLMHQVAQLEREKDDYKSQL 1499
            ..|: .::.||.:|              |..| |:||:.||..:|..:.::...:||:|:.::|.
Human  1603 GSGEGLNSPSTLECSPGSQPPSPGPATSPASP-DLDPEAVRGALREFLQELRSAQRERDELRTQT 1666

  Fly  1500 GAAKKQLQDAADQQLRCDAKLGKLQAMLRNLQEEKSNLETDRKMKISAIQA----LEEKLKHRND 1560
            .|..:||.:...::....::..:||..:...:|.:.:::.    ::|.:||    .||.::....
Human  1667 SALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDG----RLSGVQAELALQEESVRRSER 1727

  Fly  1561 ECQMLRERLAQTEMQLAATSEENGQNEERLEKSRQQCSKLDNEKRQLQEELAKVEGRASKLELQR 1625
            |.:...:::|..|..|.||..|...::|::.|.:...:||:.:||:|:|.|...|.|..||||||
Human  1728 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQR 1792

  Fly  1626 VAMEGDLTRLQMALQEKDCSIRQMAERLENQNRALTQLEDRCTALKSTVDQLKERLQKSAVSETQ 1690
            .::||:|.|.::.|.:::...:.:.:|:::..|.:...|.:...|:.||::|...|.|...||..
Human  1793 RSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA 1857

  Fly  1691 LRGEIKTLQKELSEQGHCSQANEDKLKLVQKSLQTAENEKRILTERLDSAQTNLNELRRSQQAQL 1755
            ||.:::.|.:.|::......:..||...:||:|...|:::::|.||||:|:..|:|.|:...:..
Human  1858 LRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLG 1922

  Fly  1756 DGNQRLQEQVTDLEVQRSALESQLR----IAKWNQESGGDKDLTNGNGGGNGEEELSRQLKSSQR 1816
            :..|.|:.:|.|||:||...|.||:    :.:..||               ||......::..|.
Human  1923 EQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE---------------GEAAALNTVQKLQD 1972

  Fly  1817 EKSELRSKLQTLQDKVKQLECDR-----------KSKFSGGNAYDRAEKSNSFYGGAAESGEFDS 1870
            |:..|:.:|.:||..:.|||.::           |.:.:.....|:.|:..      ..|.| |:
Human  1973 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREK------LRSHE-DT 2030

  Fly  1871 NRYDVGGGNAGGGSFNCGLDHSV--IEQETRDLRLKVRRLETLLAEKESELARCKARMNDSAKCH 1933
            .|.....|.         ||.::  .|.|..:.:.::::||..:...|.  :...|::...|:..
Human  2031 VRLSAEKGR---------LDRTLTGAELELAEAQRQIQQLEAQVVVLEQ--SHSPAQLEVDAQQQ 2084

  Fly  1934 D---GLDGDRYRSAQMHAEKLLDAREQSHRQQVLRLENQISMLREQLAQEAKR 1983
            .   ..:.:|.||||...|:.|:|||::|||:|..||.|:|.|:.||.||.:|
Human  2085 QLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRR 2137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Root	NP_001287497.1	Rootletin	110..332	CDD:291694	70/221 (32%)
		Smc	555..1384	CDD:224117	237/846 (28%)
		SMC_prok_B	991..>1779	CDD:274008	239/815 (29%)
CROCC	XP_011540770.2	SMC_N	<214..>764	CDD:330553	155/569 (27%)
		Rootletin	290..467	CDD:317452	70/220 (32%)
		SMC_N	747..1560	CDD:330553	239/823 (29%)
		SMC_N	<1269..2000	CDD:330553	216/760 (28%)
		SMC_N	1900..>2135	CDD:330553	72/267 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	587	1.000	Domainoid score	I201
eggNOG	1	0.900	-	-		E1_2CMIF
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16811
Inparanoid	1	1.050	708	1.000	Inparanoid score	I653
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46615
OrthoDB	1	1.010	-	-		D48753at33208
OrthoFinder	1	1.000	-	-		FOG0001653
OrthoInspector	1	1.000	-	-		otm40904
orthoMCL	1	0.900	-	-		OOG6_106109
Panther	1	1.100	-	-	LDO	PTHR23159
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5360
SonicParanoid	1	1.000	-	-		X3005
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.960