Protein Alignment Root and CROCC2

DIOPT Version :9

• Sequence 1: NP_001287497.1
• Gene: Root / 42860
• FlyBaseID: FBgn0039152
• Length: 2048
• Species: Drosophila melanogaster
• Sequence 2: NP_001338234.1
• Gene: CROCC2 / 728763
• HGNCID: 51677
• Length: 1653
• Species: Homo sapiens
• Alignment Length: 2065
• Identity: 460/2065 - (22%)
• Similarity: 809/2065 - (39%)
• Gaps: 566/2065 - (27%)

  Fly    28 SATASRLPFSRSQRGRDPSASGASVSAS----VAGGLTPRMMSPGPPGAGGGGGGGVSGGGSGDP 88
            |.||||...:.:.||....||...|...    |||.|     |..||.|           |..:|
Human    34 SPTASREDRALTVRGEGRQASPTPVPTRIREIVAGSL-----SEEPPQA-----------GVQEP 82

  Fly    89 SALLRQNQELRQRLADESHSYRRRLDTYKQAQHNQANLVSRLQSKIQQYRQRCSDLEERMHETIK 153
            :|.:.:.||..:.|.:|   ..|..|...||...:..|.|           ||..:.|::...::
Human    83 TATVARVQEENELLQEE---LTRLGDLLAQASAERDELAS-----------RCRVVSEQLQARLE 133

  Fly   154 PTAGVGPKLTTGPTNQVLCSTSLTLGQSSLPCSSSLDSPPPSCSRDYVDDVLVTGGGAGAAELCR 218
                               :|...|.:|.|..|..|:                        |...
Human   134 -------------------TTEAQLRRSELEHSVDLE------------------------EALG 155

  Fly   219 KLEEEHQRCEQIVAQNSALRQQLEESNRTNEALTNDLQKLTNDWASLRDELLIKEDEFKEEEQAF 283
            :||...:|...:...|:.||:|||...:.|:||..:|..:|.....|:.||.::    :..::..
Human   156 RLEAAEERSTGLCQVNALLREQLEHMKKANDALGRELAGMTGSVQRLQGELELR----RWAQRQT 216

  Fly   284 KDYYNSEHNRLLKMWREVVAVKRSFKEMQTAMKAEVAKMGQEINCVGKDINGSNATVAFAVQQAK 348
            :.....:...||.:||:.|.:.....|::.|.:..:|           |:....|..|..:..|.
Human   217 RSGGLGQPRDLLLLWRQAVVLGTDLAELRVATERGLA-----------DLQADTARTARRLHTAC 270

  Fly   349 RAADDELKQSQRSNDELQNQLATLKVQYESARHEIMERDQRLLELMNQLKKLEDRCAQAESQAAL 413
            ...|..|:.|..|.      .:||              .|:|.:...::.:|:.|. .|| :.||
Human   271 LNLDSNLRLSASST------ASTL--------------GQQLRDKAGEMLQLQGRW-DAE-KVAL 313

  Fly   414 ASRYSDE---IERLNNSMREIAQAVV---QDAENADREADAEVTGGVMQHMHLTRDAASVVGGAG 472
            .:|.|::   :|:|.....:.|:.:.   .|.:|...:.||..       :.|           .
Human   314 QARLSEQTLLVEKLTEQNEQKAKTIAALRTDLQNLVAQEDARC-------LEL-----------A 360

  Fly   473 GAGSTAGGGGKSPRRNSTRA-------------SQAFAEGTISAVQAALHKYQLALHDMQVKFQN 524
            |:..|..|..:.|.|:..||             |.|..:..:.|::||:.:......::.::.::
Human   361 GSSITELGEPRRPLRSPQRATSPHQGASPPHICSPATLDPALQAMRAAIERRWRREQELCLQLKS 425

  Fly   525 TSETLRTTKAQLETSEGTKQL-LTTKMQQLTEKLDSSNSKLSELLQERESLQRGLDDIRVQKQQS 588
            :...:.:.:.||  ||..::| ...|:||         .:..|..:|||:|:..|:..|::.||.
Human   426 SQALVASLQEQL--SESRRELWAAQKLQQ---------ERAREQAREREALRGQLEAQRLEVQQC 479

  Fly   589 E-----MGR--ADINSAFENL-----SSDYEK--MQLNCGKLQKRIDSMEEDKKAVELEIQRILK 639
            .     :||  |.:....|.|     ::|.||  ::....:||:.:....|.::.:.|..:|..:
Human   480 RASCKLLGREKAALEMVVEELKGKADAADAEKQGLEAEAAELQRSLLLQAERREELALRRERSCR 544

  Fly   640 DKNITELNLRSEEDRSSRLREETISLREELNRVSLNRDLLEQQRIESDNLINLLEKQKSDLEYDL 704
            ....::..|:..|::.|.||||..|:||.|:...|.||::|.:|....:.:...|...:|||
Human   545 ALETSQGRLQQLEEKVSGLREELASVREALSTAQLQRDVVESEREGLRSALARAECSNADLE--- 606

  Fly   705 DKLLLEKCDLQEKHEKLSNNSCSTSDELKSVQNCLQEAQEERKKLRIQSVDQCNEIG-ELKKELA 768
              ||:         .:|.:......|.|.::...::...:::..|        |.:. :|::|..
Human   607 --LLV---------RRLKSEGVEQRDSLAAMAALMEGLAQDKSAL--------NHLALQLEQERD 652

  Fly   769 ILDKARLELETDNLSAGEKL-------------------KCLQLE--KEKILQDLACVTRDRGDI 812
            .|.:.|..||.:...|||:|                   .|.:||  :|::....|.:.|::..:
Human   653 QLREQRKTLEQERARAGEQLAQAEQQLALERAERRGLQQACGRLEQRQEQLEGQAALLGREKAQL 717

  Fly   813 HNQLTAMCRKKEALNEELMRTRQ-------RLEQTTETNSRLNRNLEEMVKDVEEKQVVIDLHEK 870
            ..|:..:..:|:||.|:|.::.|       .|:|..:....|:....:::    .||..:   |:
Human   718 QEQVGQVTCQKQALEEQLAQSLQDQEAQMGTLQQALQGKDALSEERAQLL----AKQEAL---ER 775

  Fly   871 DTHRLNELLAALRSEKESLESVLFD-----TNTSLEATEERRS-------------QLERDLQEA 917
            ......|..|.||.|::||||.|.:     |....:..||.||             ||:.|.:
Human   776 QGRLAAEEAADLRVERDSLESSLLEAQQLATKLQEQLEEEARSAGLARQALQVEMEQLQSDWE-- 838

  Fly   918 LVREESLKNHVARLQKELEQCQRKAQETKTQLLNAARAAESDFNQKIANLQACAEEAAKRHGEEI 982
             |:|..|:....|||:::.|.:|:||          ||.||   |.:|:.:|.|:   .:..:|.
Human   839 -VQEMKLRQDTVRLQRQVAQQEREAQ----------RALES---QALAHREALAQ---LQREKET 886

  Fly   983 LQLRNALEKRMQQALQALQTAKDDEIEKLQERLATLQAHLESLVQQHEEALIRAESEKQQALLIA 1047
            |.|..|.||.:.:.  .|:..|:...:...||.| |:..::||.|:.:|:|::.|.:.||||.:.
Human   887 LSLTLAEEKEVARC--QLEQEKELVTKSAAEREA-LKGEIQSLKQERDESLLQLEHKMQQALSLK 948

  Fly  1048 HRDKQAVAERLEAVSRDLKTEQESLDRSRREANARDEKQRAAIAQLKDEMVQMRTKEEEHKIKLE 1112
            ..::..::|.|....|       :|:|.::||.::.|:.:|.|:...:|:..::.       :.|
Human   949 ETERSLLSEELSRARR-------TLERVQQEAQSQQEQAQATISATTEELKALQA-------QFE 999

  Fly  1113 ECIRKQELQLSSLRE-------ERESLCRVSEELKMEIRLKEDRMESTNNELQDALRKSKEGEGF 1170
            :.|...:.:.::|||       ||..:.|.:|.|:.::.:.::.:.:...||| .:.:|:||
Human  1000 DAITAHQRETTALRESLQDLAAERGDVEREAERLRAQLTVAQEGLAALRQELQ-GVEESREG--- 1060

  Fly  1171 IDSLRKELTDCRRQLADSNIERDKYSGSNKELRDHVKRVESAKREQARAIEEALQKISNLEDTKN 1235
               |.:|..:.||.|:|...|:|.....|.|||..:.|.|..|....|:.||..||:..||:.:.
Human  1061 ---LHREAQEARRALSDEAREKDVLLLFNSELRATICRAEQEKASFKRSKEEKEQKLLILEEAQA 1122

  Fly  1236 SLENERTRLSTILKETENHFTKTTQDLNATKAQLQKAQVEFAQKDEGGKELQCKLVAEVELKERA 1300
            :|:.|.:.|...|.|.|.......|:|.....|::..:.|..::.....|||.          :.
Human  1123 ALQQEASALRAHLWELEQAGGDARQELRELHRQVRTLKAENQRRSGEAHELQA----------QC 1177

  Fly  1301 QQELCQIKKQLSDLEANLCATRQELGRARCQNNQEEHRFHAREQELAQRLEEGRGREKRLEDQKH 1365
            .||:.::::|.:..||.....|:|:...:.:..:.|....|..|.|.:.|.|.||.|:.|..:.|
Human  1178 SQEVLELRRQAAKAEAKHEGARKEVLGLQRKLAEVEAAGEAHGQRLQEHLRESRGAEQTLRAELH 1242

  Fly  1366 NLEVCLADATQQIQELKARLGGAEGRIRALDEQLSCVELHKRDTEQKLSSVVHTLRRIAGIQVDG 1430
            ::...|.:|:.....|:|||..|..||.:|:::|:..|..::|.|.:|..:..||||..|:|...
Human  1243 SVTRKLQEASGVADALQARLDQACHRIHSLEQELAQAEGARQDAEAQLGRLCSTLRRGLGLQRQS 1307

  Fly  1431 SVNLSHRLLSPSRRFSPSRSCGDYDNRSTSQCPDGPID-------------VDPDLVRKGVRNLM 1482
            ......:..||::....|::.......|....|..|:.             :|...|:..:|:.:
Human  1308 PWASPEQPGSPTKGSDSSQALPGQQGTSPPARPHSPLRWPSPTPGGRSSELMDVATVQDILRDFV 1372

  Fly  1483 HQVAQLEREKDDYKSQLGAAKKQLQDAADQQLRCDAKLGKLQAMLRNLQEEKSNLETDRKMKISA 1547
            .::.:.:||:||.:.|:.....:|.:|..:..|..:::|:||..|...:|.:..:| .......|
Human  1373 QKLREAQRERDDSRIQMATLSSRLSEAECRCARAQSRVGQLQKALAEAEEGQRRVE-GALSSARA 1436

  Fly  1548 IQALEEKLKHRNDECQMLRERLAQTEMQLAATSEENGQNEERLEKSRQQCSKLDNEKRQLQEELA 1612
            .:||:             :|.|.:.|::..|:....||                 |||:|||:
Human  1437 ARALQ-------------KEALRRLELEHLASVRAAGQ-----------------EKRRLQEQ-- 1469

  Fly  1613 KVEGRASKLELQRVAMEGDLTRLQMALQEKDCSIRQMAERLENQNRALTQLEDRCTALKSTVDQL 1677
                    ||..|.|:|......|        .:.:..:.||.|   ||.||.||
Human  1470 --------LETLRQALEESRRHSQ--------GLAKQGKLLEEQ---LTNLEHRC---------- 1505

  Fly  1678 KERLQKSAVSETQLRG-EIKTLQKELSEQGHCSQANEDKLKLVQKSLQTAENEKRILTERLDSAQ 1741
                ||:.||...||. |.:||::|           ||..:|      .||.      |:||.
Human  1506 ----QKAEVSLEPLRQMEQETLKRE-----------EDVARL------GAEK------EQLDQ-- 1541

  Fly  1742 TNLNELRRSQQAQLDGNQRLQEQVTDLEVQRSALESQLRIAKWNQESGGDKDLTNGNGGGNGEEE 1806
             :||.|.:.....|..||:||.|:|::|
Human  1542 -SLNSLHQEVDGALRQNQQLQAQMTEME------------------------------------- 1568

  Fly  1807 LSRQLKSSQREKSELRSKLQTLQDKVKQLECDRKSKFSGGNAYDRAEKSNSFYGGAAESGEFDSN 1871
                                                                             
Human  1569 ----------------------------------------------------------------- 1568

  Fly  1872 RYDVGGGNAGGGSFNCGLDHSVIEQETRDLRLKVRRLETLLAEKESELARCKARMNDSAKCHDGL 1936
                                          :...:||:.|.|:.:.:||               .
Human  1569 ------------------------------QAHTQRLQDLTAQHQRDLA---------------T 1588

  Fly  1937 DGDRYRSAQMHAEKLLDAREQSHRQQVLRLENQISMLREQLAQEAKRRQQ 1986
            :.:|...|:..|.:.|:::|.:|:|||..||.|::.|:|||.||.:.|||
Human  1589 EAERLHGARPQATQALESQEWTHQQQVKVLEEQVASLKEQLDQEVQWRQQ 1638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Root	NP_001287497.1	Rootletin	110..332	CDD:291694	41/221 (19%)
		Smc	555..1384	CDD:224117	219/896 (24%)
		SMC_prok_B	991..>1779	CDD:274008	200/808 (25%)
CROCC2	NP_001338234.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		9/22 (41%)
		Rootletin	120..265	CDD:373494	38/202 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	367..396		6/28 (21%)
		EnvC	401..>606	CDD:227278	51/215 (24%)
		SMC_prok_B	538..1293	CDD:274008	210/836 (25%)
		PTZ00121	<1051..>1639	CDD:173412	188/844 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1302..1356		8/53 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146339
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48753at33208
OrthoFinder	1	1.000	-	-		FOG0001653
OrthoInspector	1	1.000	-	-		otm40904
orthoMCL	1	0.900	-	-		OOG6_106109
Panther	1	1.100	-	-	O	PTHR23159
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850