DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Root and Jmy

DIOPT Version :9

Sequence 1:	NP_001287497.1	Gene:	Root / 42860	FlyBaseID:	FBgn0039152	Length:	2048	Species:	Drosophila melanogaster
Sequence 2:	NP_067285.2	Gene:	Jmy / 57748	MGIID:	1913096	Length:	983	Species:	Mus musculus

Alignment Length:	1123	Identity:	228/1123 - (20%)
Similarity:	387/1123 - (34%)	Gaps:	357/1123 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 TLKVQYESAR-HEIMERDQRLLELMNQLKKLEDRCAQAESQAALASRYSDEIERLNNSMREIAQA 434
            ||:..:.:.| |...||::.....:....::|.:.|        .:.::...:|..:..||.|..
Mouse     8 TLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFA--------ITCHNRTAQRQRSGSREQAGT 64

  Fly   435 VVQD--------AENADREADAEVTGGVMQHMHLTRDAASVVGGAGGAGS--------TAGGGGK 483
            ...|        |.....||.|..|..:.........|.:..|....|.|        .||.|.:
Mouse    65 PASDGSRGPGSPAARGRSEAAASATAALRSPGPRKSQAWAEGGSPRSARSLKGDPPRGPAGRGPE 129

  Fly   484 SPRRNSTRA-------SQAFAEGTISAVQA-------------------ALHKYQLALHDMQVKF 522
            ||.|:..||       |....:.|.||..|                   |:.: ::.:.:| |:.
Mouse   130 SPLRSPARAKASPLRRSAESRDATASATPAPPAPPVPPVSSVRVVSASGAVSE-EIEVLEM-VRE 192

  Fly   523 QNTSETLRTTK-----AQLET-SEGTKQLLTTKMQQLT---EKLDSSNSKLSELL---------- 568
            ....:.|..::     |:||: :|..........|.|.   ::|.|.||:|...|
Mouse   193 DEAPQPLPDSEQPPSAAELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGM 257

  Fly   569 -------------QERES--------LQRGLDDI--RVQKQQSEMGRADINSAFENLS----SDY 606
                         ||.::        |..|||..  ::..|.......|....:|:||    ..|
Mouse   258 WTVLFGGAPEMTEQEIDALCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYYESLSELRQKGY 322

  Fly   607 EKMQLNCGKLQKRIDSMEEDKKAVELEIQRILKDKNITELNLRSEEDRS-SRLREETIS------ 664
            |::   ..:.::||..:.:..|.:|..::.         |:|...||.: |.|.|.|..
Mouse   323 EEV---LQRARRRIQELLDKHKTIESMVEL---------LDLYQMEDEAYSSLAEATTELYQYLL 375

  Fly   665 -----------LREELNRVSLNRDLLEQQRIESDNLINLLEKQKSDLEYDLDKLLLEKCDLQEKH 718
                       ||.:..::|:..|.|..:||||      |:|:.:|.:......:|...||..|:
Mouse   376 QPFRDMRELAMLRRQQIKISMENDYLGPRRIES------LQKEDADWQRKAHMAVLSIQDLTVKY 434

  Fly   719 EKLSNNSCSTSDELKSVQNCLQEAQEERKKLRIQSVDQCNEIGELKKELAILDKARLEL----ET 779
            .:::                                        .|.:.|:.|:.|.:.    :.
Mouse   435 FEIT----------------------------------------AKAQKAVYDRMRADQKKFGKA 459

  Fly   780 DNLSAGEKLKCLQLEKEK-ILQDLACVTRDRGDIHNQLTAMC--RKKEALNEELMRTRQRLEQTT 841
            ...:|.|:::.||....| .||.:            :...:|  :||.||.||:    |.|:..|
Mouse   460 SWAAAAERMEKLQYAVSKETLQMM------------RAKEICLEQKKHALKEEM----QSLQGGT 508

  Fly   842 ETNSRLNRNLEEMVKDVEEKQVVIDLHEKDTHRLN----------ELLAALRSEKESLESVLFDT 896
            |..:||:: ||....|::     :.|:|.....|.          |.:..|.|||.. |.|.:||
Mouse   509 EAIARLDQ-LESDYYDLQ-----LQLYEVQFEILKCEELLLTAQLESIKRLISEKRD-EVVYYDT 566

  Fly   897 NTSLEATEERRSQLERDLQEALVREESLKNHVARLQKELEQCQRKAQETKTQLLNAARAAESDFN 961
            ..|:||      .||::...|.|       |..|  :||::.|:||::     |.|.|...|
Mouse   567 YESMEA------MLEKEEMAASV-------HAQR--EELQKLQQKARQ-----LEARRGRVS--- 608

  Fly   962 QKIANLQACAEEAAKRHGEEILQ-LRNALEKRMQQALQALQTAKDDEIEK-----LQERLATLQA 1020
            .|.|.|:...|....:|.|:..| .::..|.|....:|..:....||.|:     .|||..||.
Mouse   609 AKKAYLRNKKEICIAKHHEKFQQRFQSEDEYRAHHTIQIKRDKLHDEEERKSAWVSQERQRTLD- 672

  Fly  1021 HLESLVQQHEEALIRAESEKQQALLIAHRDKQAVAERL--EAVSRDLKTEQESLDRSRREANARD 1083
            .|.:..|::...:|.    |...|.:||..:::.|..:  |.....|.|..:.
Mouse   673 RLRTFKQRYPGQVIL----KSTRLRVAHSRRKSTASPVPCEEQCHSLPTVLQG------------ 721

  Fly  1084 EKQRAAIAQLKDEMVQMRTKEEEHKIKLEECIRKQELQLSSLREERESLCRVSEEL--------- 1139
             :::..:.....::...:|.|.:..::||: ...::|:.:||...    ..||.||
Mouse   722 -QEKTEVGGGGSQLGPSQTAEPQSLVQLED-TSSEQLESTSLPPR----AVVSSELPPPQSAPLL 780

  Fly  1140 ---------------------------------KMEIRLKEDRMESTNNEL--QDALR------- 1162
                                             ...:.:.:|...||..|.  :||||
Mouse   781 TSIDPKPCSVTIDPLPPPLPPTPPPPPPPPPPPPPPLPVAKDNGASTTAETLEKDALRTEGNERS 845

  Fly  1163 ----KSKEGEGFIDS---------LRKELTDCRRQLADSNIERDKYSGSNKELRDHVKRVESAKR 1214
                .|.......||         |||.:...:|:...|.:  |:...|.|....|:|:||
Mouse   846 IPKSASAPAAHLFDSSQLVSARKKLRKTVEGLQRRRVSSPM--DEVLASLKRGSFHLKKVE---- 904

  Fly  1215 EQARAIEEALQKISNLEDTKNSLENER--TRLSTILKET-ENHFT------KTTQDLNATKAQLQ 1270
                  :..|....:.:|:.|.|...|  .:|..:.||. ...||      ..|:.::....:::
Mouse   905 ------QRTLPPFPDEDDSNNILAQIRKGVKLKKVQKEVLRESFTLLPDTDPLTRSIHEALRRIK 963

  Fly  1271 KAQVEFAQKDEGGKELQC 1288
            :|..|...::|.   |.|
Mouse   964 EASPESEDEEEA---LPC 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Root	NP_001287497.1	Rootletin	110..332	CDD:291694
		Smc	555..1384	CDD:224117	183/887 (21%)
		SMC_prok_B	991..>1779	CDD:274008	71/378 (19%)
Jmy	NP_067285.2	Interaction with p300/EP300. /evidence=ECO:0000269\|PubMed:10518217	1..119		22/118 (19%)
		WHAMM-JMY_N	6..54	CDD:292542	8/53 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..167		27/116 (23%)
		JMY	220..573	CDD:292496	91/439 (21%)
		Interaction with p300/EP300. /evidence=ECO:0000269\|PubMed:10518217	469..558		28/110 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..855		20/136 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..983		5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000